RESUMEN
Objective:to investigate the efficacy of drugs in the treatment of laryngeal granuloma after hypothermic plasma radiofrequency surgery in early glottic carcinoma.Methods:Thirty-two cases of laryngeal granulomacoming from 289 patients with early glottic carcinoma treated by plasma radiofrequency surgery under endoscope-supported laryngoscopefrom January 2011 to January 2021 in Dalian Municipal Central Hospital were enrolled. All patients were given oral treatment of zinc gluconate tablets (70 grams per tablet, containing 10 grams of zinc). The usage was 3 tablets each time, twice a day. If the granulation was located in the vocal cord, 20 mg of esomeprazolec was added twice a day, and taken orally on an empty stomach. The total course of treatment was 6-12 weeks.Results:Follow-up and reexamination of electronic laryngoscope showed that the granulation of all patients began to become smaller after 3 weeks of drug treatment and gradually disappeared after 6-12 weeks. After the granulation disappeared, the drug was stopped, and there was no recurrence.Two patients developed nausea and epigastric discomfort after oral administration of zinc gluconate tablets for 3 weeks, and the discomfort disappeared after reducing the dose.Conclusions:Oral administration of zinc gluconate tablets alone or in combination with esomeprazoleis an effective, safe and low recurrence method for laryngeal granuloma after hypothermic plasma radiofrequency ablation in early glottic carcinoma.
RESUMEN
[ABSTRACT]OBJECTIVETo assess the efficacy of proton pump inhibitor (PPI) on the treatment for laryngeal contact granuloma.METHODSSixty seven patients with laryngeal contact granuloma who were diagnosed in our department from March 2010 to October 2014 were enrolled in this study and all patients received PPI therapy, meanwhile the clinical data of the patients was analyzed. The follow-up period was at least half a year.RESULTS The 67 patients were treated well with the PPI. Fifty patients were cured, 11 patients were obvious improved, 4 patients were improved and 2 patients were invalid. The total efficacy rate was 97.01%. The average time of PPI used in small lesion group was shorter than that in large lesion group.CONCLUSIONPPI is effective for laryngeal contact granuloma, it can be recommended the first choice for the treatment of the disease.