RESUMEN
With decreasing incidence of cervical pathology in western world due to increasing awareness and screening programme. Contrary to it in India and developing countries cervical lesion, particularly cervical carcinoma is the leading cause of increasing morbidity, mortality and financial burden on society. The present study is an insight into the epidemiological profile of cervical lesion on Pap smear and histopathology finding in Kosi region of Bihar. The study was carried over the period of 2 years 8 months. Total 154 patients were enrolled in this study and were analysed for age, socio-economic status, parity, age at first pregnancy and symptoms using Pap smear with histopathological finding of cervical lesions. Data were analysed of which 79.23% (122) patients were in age groups 21-40 years, 72.08% (111) were from low socio-economic status, and 70.78% (109) were with parity 4 and more. 66.88% (103) patients delivered their first child below 20 years of age. 69.49% (107) patients presented with foul smelling vaginal discharge and pelvic pain. On pap smear and histopathological findings preinvasive (dysplasia, LGSIL, HGSIL) and invasive stage (carcinoma) constituted 26.61% (41) cases. The epidemiological pattern of cervical lesion in kosi region of Bihar is different from other study with presentation in younger age groups, high parity and markedly increased incidence of premalignant and malignant lesion on pap smear and histopathology findings.
RESUMEN
Background: Cervical cancer remains a major public health problem in northern Argentina, showing the highest mortality rate in the country (approximately 22 cases/100000 women). Objective: The aim of this study was to provide epidemiological data on the prevalence and type distribution of human papillomavirus (HPV) in women with pre-neoplastic lesions before the massive introduction of HPV vaccination in the country. Materials and Methods: Exfoliated cervical cells were collected to screen for HPV using the widely known MY09/11 PCR, followed by the restriction fragment-length polymorphism (RFLP) technique from a total of 714 women with previously diagnosed atypical squamous cells of undetermined significance (ASCUS), low-grade squamous intraepithelial lesion (LG-SIL) and high-grade squamous intraepithelial lesion (HG-SIL). Results: Overall HPV prevalence was 48.2% in ASCUS (24 different HPV types detected), 66.5% in LG-SIL (37 HPV types detected) and 82.6% in HG-SIL (16 HPV types detected). HPV-16 was the most prevalent type among all cases. With respect to multiple HPV infections, 9.6% were observed in ASCUS, 14.3% in LG-SIL and 11.4% in HG-SIL. Conclusion: The major strength of our study is the assessment of a large series of women with cytological alterations in this region. The information attained will be useful as a regional baseline for future epidemiological vigilance, in the context of the national HPV vaccination program.