RESUMEN
Objective: To assess HIV-free survival and nutritional status of HIV-exposed infants.Methods: This retrospective cohort study was conducted on infants born to woman with HIVinfection born at our Institute between January 2011 to March 2016, and followed usingcurrent National guidelines. HIV transmission rate, HIV-free survival, and nutritional statuswere assessed 18 months age. Results: Of the 155 infants, 10 (6.5%) died before 18 monthsof age. Two of 145 surviving infants were confirmed HIV-positive, the remaining were HIV-negative at 18 months (HIV-free survival 92.3%). Of the 10 infants who died, one wasconfirmed HIV-positive and three negative; the rest died before their HIV status could beascertained. HIV infection rate among the 149 infants for whom the test reports were availablewas 2%. At 18 months age, 14% HIV-uninfected infants were wasted, 28% stunted, and 3%had microcephaly. Conclusions: Infants born to mothers with HIV managed as per thecurrent National guidelines have a good outcome at 18 months of age.
RESUMEN
Human immunodeficiency virus (HIV) clades B and C account for more than 60 percent of the HIV-1 infections worldwide. In this paper, we describe the profiles of patients infected with subtypes of HIV-1 from the state of Paraná, Southern Brazil, and correlate them with demographic and epidemiological findings. A retrospective analysis of HIV cases reported from 1999-2007 was also performed. Data from 293 patients were reviewed and 245 were older than 13 (58 percent female). The distribution of clades was as follows: B 140 (57 percent), C 67 (23 percent), F 24 (10 percent) and mosaic or unique recombinant forms (URFs) 24 (10 percent). Of the 48 patients younger than 13 years of age (62.5 percent male), vertical transmission occurred in 46 and the distribution of clades was as follows: B 14 (29 percent), C 24 (50 percent), F 7 (15 percent) and URFs 6 (13 percent). There was no significant difference in mortality between HIV-1 subtypes. In both groups, patients infected with clade C tended to have higher rates of injection drug use exposure risk.