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Objective The aim of this study was to describe the prevalence of malignant tumors in Harbin from 2015 to 2017 and provide the scientific evidence for cancer prevention and control. Methods The morbidity and mortality data of malignant tumors in Harbin were collected by Harbin Cancer Registry and Reporting System,and the incidence and death distribution of malignant tumors were described. Results In 2015-2017,there were 77,379 new cases of malignant tumors and 49,450 deaths in Harbin. The crude incidence of malignant tumors was 243. 51/105,age-standardized incidence rates by Chinese standard population(ASIRC)was 171. 76/105 in Harbin. The crude mortality of malignant tumors was 155. 62/105,age-standardized mortality rates by Chinese stand-ard population(ASMRC)was 106. 79/105 in Harbin. The top 5 malignant tumors were lung cancer,colorectal cancer,thyroid cancer, breast cancer and liver cancer. The top 5 deaths were lung cancer,liver cancer,gastric cancer,colorectal cancer and pancreatic canc-er. Conclusion The burden of malignant tumors is serious in Harbin. Lung cancer,liver cancer,gastric cancer,colorectal cancer,thy-roid cancer and female breast cancer are the main malignant tumors that threaten residents.
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<p><b>OBJECTIVE</b>To analyze the allergic status to common inhalant allergens and food allergens in clinical patients in Harbin in northeastern China and provide evidence to develop the prevention strategy of allergic disease.</p><p><b>METHODS</b>The data were collected from 5 473 patients with clinical suspected allergic diseases seeking medical care in the Second Affiliated Hospital of Harbin Medical University. Among these patients, 2 530 (46.2%) were males aged 0-86 years, the youngest was only 1 month old and 2 579 (47.1%) were young children and teenagers. The serum specific Immunoglobulin E (sIgE) to 14 kinds of common allergens and serum total IgE were detected by using AllergyScreen test (Mediwiss Analytic GmbH, Moers, Germany).</p><p><b>RESULTS</b>In 5 473 subjects the positive rate of sIgE was 33.1% (n=1 813). Cow milk (6.9%) and wheat (3.1%) were the most common food allergens, followed by house dust mite mix (12.5%) and mould mix (9.4%) and the age and gender specific differences in the positive rate were significant. For the children aged <7 years the positive rates to cow milk, beef-mutton, and egg white/egg yolk were high, but the positive rates to house dust mite mix, ragweed estragon, and mould mix were low (P<0.05). For the adults the positive rates to aeroallergens were high while the rates to food allergens were low.</p><p><b>CONCLUSION</b>The results from this study showed that the food allergens in Harbin had geographic characteristics, which support the viewpoint that the environment factors play an important role in the incidence of allergic diseases. Also, the detection of sIgE and total IgE are essential to identify relevant allergens for the purpose of early diagnosis, management and prevention of allergic disease.</p>