Effects of induced hypotension on the safety of acute normovolemic hemodilution in anesthetized dogs / 中华麻醉学杂志

Objective: To evaluate the safety of acute normovolemic hemodilution (HD)during induced hypotension (IH). Method: 12 healthy mongrel dogs, were anesthetized and paralysed with sodium pentobarbital and pipecuronium. Ventilation was controlled. Hypotension was induced with nicardipine to lower the MAP by 30% after Hct was reduced to 0.35,0.30,0.25,0.20,0.15 or 0.10 respectively. Blood gases,lactate level(LAC)and hemedynamic variables were measured 15 minutes after HD and 20 minutes after IH. Result: Compared with HD alone, when combined with IH, CI.DO_2 and LAC increased significantly (P