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Objective To investigate the effect of high sodium diet on the prevalence and mortality of gastric cancer in Xi'an , and to provide reference for its clinical treatment and prevention. Methods A questionnaire survey was conducted on 604 inpatients in tertiary hospitals in Xi'an from 2018 to 2020, and data including medical history, medication use, daily sodium intake and gastric cancer incidence were collected. A one-year follow-up was completed, and all-cause mortality was recorded during the follow-up period. Results A total of 604 cases , there were 81 cases of gastric cancer and 523 cases of non-gastric cancer, with a prevalence rate of 13.41%. Among patients with gastric cancer, 49 (8.11%) were male and 32 (5.30%) were female. There were 9 cases (1.49%) aged 30-40 years, 14 cases (2.32%) aged 41-50 years, 27 cases (4.47%) aged 51-60 years and 31 cases (5.13%) aged 60 years and above. The gastric cancer and non-gastric cancer patients yielded no statistical difference in terms of age, gender and medical history (P>0.05), while the proportion of sodium intake was significantly higher in gastric cancer patients than in non-gastric cancer patients (P<0.05). Logistics analysis showed that high sodium diet was a risk factor for the development of gastric cancer (P<0.05). The proportion of high sodium diets was 40.89% (247/604) in all selected individuals, 72.84% (59/81) in gastric cancer patients and 35.95% (188/523) in non-gastric cancer patients. The proportion of patients on a high sodium diet demonstrated statistical difference between gastric cancer and non-gastric cancer patients (P<0.05). One-year follow-up showed that 58 of 81 gastric cancer patients survived (71.60%) and 23 died (28.40%), including 20 survivors (34.48%) and 17 deaths (73.91%) on a high-sodium diet. Significant difference was found in the proportion of patients on high sodium diet between dead and surviving gastric cancer patients (P<0.05). Conclusion The prevalence and mortality rate of gastric cancer caused by high sodium diet is high among residents in Xi'an , clinical guidance on sodium intake is of great importance to patients.
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Objectives: To investigate the impact of high-salt diet on plasma level of vascular endothelial growth factor C (VEGF-C) in healthy subjects and hypertension patients; to explore the relationship between VEGF-C level and blood pressure (BP). Methods: Our research included in 2 groups: Essential hypertension (EH) group, 75 patients treated in our hospital from 2013 to 2014 and Control group, 98 healthy subjects at the same period. Using salt-intake 6 g/day as the borderline, both groups were respectively divided into High-sodium diet (HS) subgroups and Low-sodium diet (LS) subgroups. The age, gender, creatinine clearance (CCr), UA, fast blood glucose (FBG), body mass index (BMI), blood lipids (TC, TG, HDL-C, LDL-C), systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (PP), mean arterial pressure (MAP), heart rate (HR) and CF-PWV were compared between EH group and Control group, HS subgroups and LS subgroups. Results: Compared with Control group, EH group had increased plasma level of VEGF-C, (3 940.8±1 141.1) pg/ml vs (2 938.0±987.0) pg/ml, P<0.001; the age, BMI, SPB, DBP, PP, MAP and CF-PWV were different between 2 group, all P<0.005. In ES group, compared with LS subgroup, HS subgroup showed the higher VEGF-C (4 208.8±113.1) pg/ml vs (3 515.8±1 070.1) pg/ml, P=0.009; the age, SBP, DBP and PP were different between 2 group, all P<0.005. In Control group, compared with LS subgroup, HS subgroup showed the higher VEGF-C (3 158.7±917.2) pg/ml vs (2 655.7±1 011.3) pg/ml, P=0.012; the age BMI and CCr were different between 2 group, all P<0.005, while BP was similar between 2 subgroups. Spearman correlation study presented that with adjusted confounding factors, no matter in all participates and in EH group or Control group, MAP were positively related to plasma levels of VEGF-C (r=0.536, P<0.001 and r=0.546, P=0.002 or r=0.291, P=0.006) respectively. Conclusions: High-sodium diet could increase plasma VEGF-C level in either healthy subjects or hypertension patients, VEGF-C level was positively related to BP.