RESUMEN
Objective: To study the chemical constituents with high polarity from the whole herb of Artemisia annua. Methods: The constituents were isolated and purified by column chromatography on Sephadex LH-20, silica gel, ODS, and preparative TLC. The structures were elucidated by the analysis of the spectroscopic data. Results: Fourteen compounds were obtained from the methanol soluble fraction of the 70% ethanol extract of A. annua by maceration at room temperature and identified as artemisiannuside A (1), scopolin (2), 2,4-dihydroxy-6-methoxyacetophenone-4-O-β-D-glucopyranoside (3), methyl caffeate (4), salicylic acid (5), ferulic acid (6), vanillic acid (7), 2,4-dihydroxy-6-methoxyacetophenone (8), homoeriodictyol (9), jaceidin (10), penduletin (11), axillarin (12), eriodictyol (13), and ®-15,16-didehydrocoriolic acid (14), respectively. Conclusion: Compound 1 is a new acylated coumarin glycoside. Compound 14 is isolated from the Artemisia genus for the first time and compound 9 is firstly isolated from A. annua.