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Objective To observe the changes of serum inflammatory cytokines and clincal effect of Jiawei-Xinglou-Chengqi decoction and Huoxue-Huatan decoction on the patients with acute cerebral infarction. Methods A total of 85 stroke patients were selected from April 2015 to April 2016 in our hospital and divided into the observation group (43 cases) and control group (42 cases) using the random number method. The control group was treated with conventional therapy, and the observation group combined Jiawei-Xinglou-Chengqi decoction and Huoxue-Huatan decoction based on the treatment of control group. Thetreatment last for 2 weeks. The National Institutes of Health Stroke Scale (NIHSS) was used to assess the patients mental function defect, the Barthel Index (activities of daily living, ADL) to evaluate the ability of daily life, and the TC, TG, LDL-C, and the fibrinogen, platelet count, prothrombin time, clinical evaluation were detected and compared. Results The total effective rate of the observation group was 100.0％ (43/43), while the control group was 81.0％ (34/42), and the difference between both groups was statistically significant (χ2=9.041, P<0.01). After treatment, the NHISS (5.24 ± 2.61 vs.12.78 ± 3.93, t=10.443) in the observation group was significantly lower than the control group, and the ADL (89.75 ± 6.51 vs. 72.22 ± 5.24, t=14.197) in the observation group was significantly higher than the control group (P<0.01). The serum levels of TC (4.6 ± 0.9 mmol/L vs. 5.42 ± 0.7 mmol/L, t=21.538), TG (2.0 ± 0.8 mmol/L vs. 2.4 ± 0.6 mmol/L, t=8.585), LDL-C (2.7 ± 0.8 mmol/L vs. 3.1 ± 0.8 mmol/L, t=9.092) in the observation group were significantly lower than those in the control group (P<0.01). The fibrinogen (2.81 ± 0.46 g/L vs. 2.95 ± 0.51 g/L, t=8.592) in the observation group was significantly lower than that in the control group (P<0.01), and prothrombin time (16.14 ± 1.62 s vs. 15.34 ± 1.18 s, t=14.139) in the observation group was significantly longer than that in the control group (P<0.01). Conclusions The combination of Jiawei-Xinglou-Chengqi decoction and Huoxue-Huatan decoction could improve curative effect, reduce blood lipid, improve coagulation function, improve quality of life and promote recovery of nerve function in patients with acute cerebral infarction.
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Objective To investigate the effect of Yiqi Huoxue Huatan Formula combined with low-dose atorvastatin on arterial stiffness,blood viscosity and prognosis in the patients with high-risk chronic obstructive pulmonary disease (COPD).Methods A total of 240 patients with high-risk COPD and risk factors of cardiovascular disease were divided into the statin group(A),Yiqi H uoxue H uatan group(B),combined group(C) and control group(D),60 cases in each group.All groups were treated with routine therapy.On this basis,the group A was combined with low-dose atorvastatin,the group B was combined with Yiqi Huoxue Huatan Formula.On the basis of the group A,the group C was combined with Yiqi Huoxue Huatan Formula.All groups were treated for 6 months.The changes of TCM syndrome scores,arterial stiffness index and blood rheological indexes in 4 groups were observed and compared between before and after treatment.The situation of adverse reactions occurrence and prognosis were recorded.Results After 6 months of treatment,the TCM syndrome scores and carotid artery-femoral artery pulse wave velocity (PWV)in 4 groups were significantly decreased compared with those before treatment,which in the group C,A,B and D was gradually increased (P＜ 0.05).After 6 months of treatment,there was no significant change of whole blood viscosity and hematocrit in the group D (P＞ 0.05),which in the other 3 groups were significantly decreased compared with those before treatment,moreover the group C was significantlylower than the group A and B (P＜0.05),while there was no statistically significant difference between the group A and B (P＞0.05).The incidence rate of adverse reactions had no statistically significant difference among the four groups (P＞ 0.05).The BODE index showed gradual increase ih the group C,A,B and D (P＜0.05).Conclusion Yiqi Huoxue Huatan Formula combined with low-dose atorvastatin has an positive effect in regulating the blood rheological state and promoting the prognostic recovery in the patients with high-risk COPD and risk factors of cardiovascular disease.
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Objective To investigate the effect of Yiqi Huoxue Huatan Formula combined with low-dose atorvastatin on arterial stiffness,blood viscosity and prognosis in the patients with high-risk chronic obstructive pulmonary disease (COPD).Methods A total of 240 patients with high-risk COPD and risk factors of cardiovascular disease were divided into the statin group(A),Yiqi H uoxue H uatan group(B),combined group(C) and control group(D),60 cases in each group.All groups were treated with routine therapy.On this basis,the group A was combined with low-dose atorvastatin,the group B was combined with Yiqi Huoxue Huatan Formula.On the basis of the group A,the group C was combined with Yiqi Huoxue Huatan Formula.All groups were treated for 6 months.The changes of TCM syndrome scores,arterial stiffness index and blood rheological indexes in 4 groups were observed and compared between before and after treatment.The situation of adverse reactions occurrence and prognosis were recorded.Results After 6 months of treatment,the TCM syndrome scores and carotid artery-femoral artery pulse wave velocity (PWV)in 4 groups were significantly decreased compared with those before treatment,which in the group C,A,B and D was gradually increased (P＜ 0.05).After 6 months of treatment,there was no significant change of whole blood viscosity and hematocrit in the group D (P＞ 0.05),which in the other 3 groups were significantly decreased compared with those before treatment,moreover the group C was significantlylower than the group A and B (P＜0.05),while there was no statistically significant difference between the group A and B (P＞0.05).The incidence rate of adverse reactions had no statistically significant difference among the four groups (P＞ 0.05).The BODE index showed gradual increase ih the group C,A,B and D (P＜0.05).Conclusion Yiqi Huoxue Huatan Formula combined with low-dose atorvastatin has an positive effect in regulating the blood rheological state and promoting the prognostic recovery in the patients with high-risk COPD and risk factors of cardiovascular disease.
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OBJECTIVE:To explore the effects of Bushen huoxue huatan decoction on ovarian blood supply and form in model rats with polycystic ovarian syndrome(PCOS). METHODS:50 SD female rats were randomized into normal control group,model group,positive control group [rosiglitazone,3 mg/(kg·d)],Bushen huoxue huatan decoction low-dose and high-dose groups [5.0, 7.5 g/(kg·d)],with 10 rats in each group. Except for normal control group,PCOS model was induced in the other groups by Poresky method. After modeling,treatment groups were given relevant medicine intragastrically. The normal control group and mod-el group were given normal saline [10 mL/(kg·d)] intragastrically,once a day,for 22 days. After the end of administration,the rats were sacrificed. The microvessel density (MVD) was recorded. mRNA expression of vascular endothelial growth factor (VEGF), ovarian angiotensin Ⅱ receptor(Ang Ⅱ)type 1(AT1)and type 2(AT2),G-protein coupled receptor MAS were all detected in ovarian tissue of rats. The ovarian form was observed. RESULTS:Compared with normal control group,MVD of mod-el group and treatment groups were all increased,while mRNA expression of AT1,AT2 and MAS were down-regulated (P<0.05);cystic sinus sollicle,the decrease of granular cell layer,egg mother cells disappearance,the decrease of luteal tissue and other obvious pathological changes could be found in ovarian tissue of rats in model group. Compared with model group,above in-dexes of treatment groups were improved significantly,and the effects of Bushen huoxue huatan decoction low-dose and high-dose groups were better than that of positive control group (P<0.05). The pathological changes of ovarian tissue in treatment groups were all improved to certain extent. CONCLUSIONS:Bushen huoxue huatan decoction can improve ovarian blood supply,angio-genesis and ovulation in PCOS rats. It is beneficial to improve ovarian form.
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Objective To investigate the effect of Yiqi Huoxue Huatan Decoction(YHHD) on gene expression of vascular endothelial growth factor(VEGF), intercellular adhesion molecule 1(ICAM-1) in the colonic mucosa of ulcerative colitis rats. Methods Sixty rats were divided into six groups, namely normal control group, model control group, low-, middle- and high-dose Y HHD group(gastric gavage of YHHD in the dosage of 13, 26, 52 g·kg-1·d-1 respectively) , and Mesalazine(0.5 g·kg-1·d-1 ) group. T he rat model of ulcerative colitis was established by enema with 2, 4, 6-trinitrobenzene sulfonic acid(TNBS)mixture(2.5%TNBS and 50% ethanol). The changes in rat body weight were monitored. After treatment, pathological features of the colonic mucosa were observed under light microscope, and VEGF and ICAM-1 gene expression levels in the colonic mucosa were measured by reverse t ranscripti on polymerase chai n reaction(RT-PCR). Results Body weight was lighter, and relative gene expression levels of VEGF and ICAM-1 in the model group were significantly higher than those in the normal control group, and pathological features of the colonic mucosa was obvious, the differences being significant between the two groups(P<0.01). Compared with the model group, body weight was increased , pathological features of the colonic mucosa were relieved, and relative gene expression levels of VEGF and ICAM-1 were significantly decreased in YHHD groups(P<0.01), and high-dose YHHD showed the strongest effect. Conclusion YHHD can down-regulate the gene expression of VEGF and ICAM-1, which may be one of its therapeutic mechanisms for ulcerative colitis.
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Objective To investigate the effects of Shugan Huoxue Huatan Decoction (SHHD) on non-alcoholic steatohepatitis (NASH) of rats. Methods 32 SD male rats were randomly allocated into 4 groups:normal group, model group, Dongbao Gantai (DBG) group, SHHD group. NASH model was induced by hyperlipid diet. General condition and pathological changes of liver tissues were observed. Liver function, blood lipids, liver tissue Hyp and serum LEP were dectected. Fasting insulin resistance index (FIRI) was evaluated according to the levels of fasting blood glucose (FBG) and fasting serum insulin (FINS). Results Compared with model group, SHHD had the effects of improving liver function and blood lipids, decreasing liver tissue Hyp, LEP and FIRI siginificantly. Conclusion Inhibiting leptin and insulin resistances, enhancing the lipid metabolism are probably the main mechanisms of SHHD in preventing and treating NASH.