RESUMEN
The level of lipid peroxides (LPO)and copper-zinc containing superoxide dismutase(SOD-I) in the gastric mucosa and serum was determined in 141 samples from 25 patients after conventional subtotal gastrectomy (11 cases of Billroth I and 14 cases of Billroth Ⅱ and 11 patients after pylorus and antroseromuscular flap preserving gastrectomy (PAFPG).Those of 11 normal subjects were examined likewise to serve as control.It was found that;1.The average LPO level was much higher and the average SOD-I level much lower in the gastric mucosa after conventional subtotal gastrectomy especially the Billroth type Ⅱ than in those after PAFPG.2.In 36 specimens of stump mucosa,the average LPO level was significantly higher in the tissue around the anastomotic ring than in that of the body of the stump;no marked difference of SOD-I level between the 2 was revealed.3.The LPO value in the stump mucosa was positively correlated to and the SOD-I value negatively correlated to the pH value of gastric juice.Thess findings suggest that the reaction of oxygen free radicals in the stump-mucosa may be influenced by the intragastric pH or by the type of digestive continuity reconstruction,and that the reaction of free radicals specially lipidperoxidation may play a role in the pathogenesis of the lesions in the anastomotic stoma.
RESUMEN
The preventive effects of some drugs on pulmonary lipid peroxi-dation and inborn oxidation protectant system in the lungs were observed in rats after the animals were exposed to 200 ppm of hydrogen sulfide (H2S) for 3 hours.Malondialdehyde (MDA) level of the lungs and bronchoalveolar lavage fluid (BALF),superoxide dismutase (SOD) activity,glutathione(GSH) and vitamin E (VE) levels of the lungs were determined in the 6th and 12th hour after H2S inhalation.It was found that a significant increase of MDA level of both the lungs and BALF and a significant decrease of SOD activity and GSH and VE level occured after a single exposure to 200 ppm of H2S inhalation.On the contrany,the MAD level of every group of which the animals had been medicated for prevention was lower than that of the intoxicated groups.Among the premedicated groups,the MDA level of 4-dimethylaminophenol(DMAP) group,VE group,and NaNO2 group was not different from that of the normal except that the MDA level in BALF was higher in VE and NaNO2 group than in the control.In every premedicated groups,SOD activity was increased and GSH and VE levels were elevated.These facts suggest that DMAP,NaNO2,VE,dexamethasone and anisoda-mine all could reduce the MDA level and elevate the capacity of the oxidation protectant system of the lungs after H2S inhalation.It is concluded that there are drugs to protect victims from H2O intoxication while DMAP,NaNO2 and VE are relatively more potent among the drugs used in this study.