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Introducción: El dengue se ha convertido en una de las enfermedades de mayor impacto epidemiológico, social y económico para la salud pública a nivel mundial. Objetivo: Determinar la seroprevalencia de dengue en cinco municipios del Valle del Cauca con transmisión hiperendémica y mesoendémica de la enfermedad. Métodos: Estudio de prevalencia mediante muestreo probabilístico por conglomerados multietápico. Se evaluaron 822 personas. Resultados: La seroprevalencia de dengue fue del 91,36 por ciento obtenida a partir de la aplicación de la prueba de ensayo por inmunoabsorción ligado a enzimas para dengue indirecta IgG. Al aplicar la prueba de captura para IgM para dengue, la seroprevalencia fue de un 21,41 por ciento. La seropositividad conjunta de anticuerpos IgM e IgG fue del 20,3 por ciento. Conclusiones: La alta seroprevalencia de dengue en el Valle del Cauca muestra el impacto de esta enfermedad en la historia de vida de sus residentes. Su reemergencia impacta negativamente en los que tienen como antecedentes haber padecido la enfermedad provocando un desarrollo de su variante más grave, lo que se puede evitar con la administración de una vacuna tetravalente contra el dengue(AU)
Introduction: Dengue has become one of the largest epidemiological, social, and economic impacts for global public health. Objective: To determine the seroprevalence of dengue in five municipalities of Valle del Cauca with hyperendemic and mesoendemic transmission of the disease. Methods: Prevalence study through multistage probability sampling by clusters. 822 people were assessed. Results: Seroprevalence of dengue was of 91.36 percent, it was obtained from the implementation of the enzyme-linked immunosorbent´s trial test for indirect dengue IgG. When applying the capture test IgM for dengue, seroprevalence was of 21.41 percent. The joint seropositivity of IgM and IgG antibodies was 20.3 percent. Conclusions: The high seroprevalence of dengue in Valle del Cauca shows the impact of this disease in the life history of the residents. Dengue re-emergence impacts negatively on those who have a background of having suffered from the disease which caused a development of its most severe variant that can be avoided with the administration of a quadrivalent vaccine against dengue(AU)
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Humanos , Masculino , Femenino , Inmunoglobulinas , Estudios Seroepidemiológicos , Dengue/epidemiología , ColombiaRESUMEN
La policondritis recidivante (RP) es un trastorno autoinmune sistémico poco frecuente que se caracteriza por episodio y deterioro progresivo de la inflamación del cartílago. Aproximadamente el 30% de los pacientes con RP tienen enfermedad concurrente. Sin embargo, hay tres casos previos reportados de RP relacionado con enfermedad relacionada con la inmunoglobulina G4 (IgG4-RD). Nosotros presentamos otro caso de una mujer de 37 años que desarrolló RP aproximadamente 1 año antes del diagnóstico de IgG4-RD. La asociación entre ER-IgG4 y RP sigue sin estar clara.
Relapsing polychondritis (RP) is a rare systemic autoimmune disorder characterized by the episodic and progressive deterioration of cartilage inflammation. Approximately 30% patients with RP have concurrent disease. However, there are three cases reports of RP complicated by immunoglobulin G4-related disease (IgG4-RD). Here we report another case of a 37-year-old female who developed RP approximately 1 years before IgG4-RD diagnosis. The association between IgG4-RD and RP remains unclear.
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Policondritis Recurrente , Diagnóstico , Enfermedad Relacionada con Inmunoglobulina G4 , InflamaciónRESUMEN
La policondritis recidivante (RP) es un trastorno autoinmune sistémico poco frecuente que se caracteriza por episodio y deterioro progresivo de la inflamación del cartílago. Aproximadamente el 30% de los pacientes con RP tienen enfermedad concurrente. Sin embargo, hay tres casos previos reportados de RP relacionado con enfermedad relacionada con la inmunoglobulina G4 (IgG4-RD). Nosotros presentamos otro caso de una mujer de 37 años que desarrolló RP aproximadamente 1 año antes del diagnóstico de IgG4-RD. La asociación entre ER- IgG4 y RP sigue sin estar clara.
Relapsing polychondritis (RP) is a rare systemic autoimmune disorder characterized by the episodic and progressive deterioration of cartilage inflammation. Approximately 30% patients with RP have concurrent disease. However, there are three cases reports of RP complicated by immunoglobulin G4-related disease (IgG4-RD). Here we report another case of a 37-year-old female who developed RP approximately 1 years before IgG4-RD diagnosis. The association between IgG4-RD and RP remains unclear
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Humanos , Femenino , Policondritis Recurrente , Enfermedad Relacionada con Inmunoglobulina G4 , InflamaciónRESUMEN
This study aims to explore the diagnostic value of specific immunoglobulin E (sIgE) and specific immunoglobulin G (sIgG) of Aspergillus fumigatus in the diagnosis of allergic broncho-pulmonary aspergillosis (ABPA) and severe asthma with fungal sensitization (SAFS). A total of 17 ABPA patients and 14 SAFS patients were enrolled. The levels of sIgG [2 294.00 (1 527.00, 14 170.00) U/ml vs. 972.60 (650.90, 1 792.00) U/ml] and sIgE [8.77 (1.64, 16.85) kU/L vs. 1.04 (0.70, 2.05) kU/L] in ABPA patients were significantly higher than those in SAFS patients (P<0.05). Aspergillus fumigatus sIgG was strongly correlated with Aspergillus fumigatus sIgE (rs=0.797, P<0.001) in ABPA patients. When combined with Aspergillus fumigatus sIgG (>1 000.00 U/mL) and Aspergillus fumigatus sIgE (>1.00 kU/L), the sensitivity was 82.3% and specificity 78.6% for the differential diagnosis of ABPA and SAFS. It demonstrates the diagnostic value of Aspergillus fumigatus sIgG and sIgE.
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Objective To explore new insight into the immunopathogenesis of ulcerative colitis.Methods Immunohistochemistry for the immunoglobulin(IgG)and complement(C 3c )was performed in biopsy specimens of the mucous membrane from 50 patients with ulcerative colitis(32 in active state and 18 in inactive state)and 5 controls.Results The immunoglobulin and activated complement were found in the epithelium mucosae and basement membrane of capillary walls in ulcerative colitis,with highest density in patients with active ulcerative colitis as compared with inactive ones.Conclusions The activation of immunoglobulin(IgG)and complement(C 3c )are closely related to active ulcerative colitis which plays an important role in the tissue damage of active ulcerative colits.Immunoglobulin(IgG)and complement(C 3c )are important components of immunoregulatory network of ulcerative colitis