RESUMEN
Abstract Happiness and achieving quality of life primarily depends on the nature of the place in which we live. The religious/spiritual factor is considered a basic factor for understanding the quality of life of individuals. The study at hand used the Arabic version of WHOQoL-SRPB to analyze the religious and spiritual factor affecting the quality of life in Islamic holy cities. The scale was applied to 671 residents of Medina with an average age of 51.6 years, of which 527 (78.5 %) are males and 144 (21.5 %) are females, and they are all Muslims. The results showed that all factors have good internal consistency, since the Alpha Cronbach value was .81 at a significant level of p < .001, and its value for the factors ranged between .75-.89, which are high values and significant at p < .001 except for the "Wholeness" factor, which was significant at p < .01. Moreover, the results of the intra-class correlations coefficients (ICC) test showed that all WHOQoL-SRPB factors are acceptable, as their values ranged between (.82-.93), and all of them were significant at p < .001.