Metabolic complications of androgen deprivation therapy and its intervention management / 中华男科学杂志

Androgen deprivation therapy (ADT) is one of the dominant treatment options for advanced prostate cancer, which has been certified to significantly improve the overall survival of prostate cancer patients. However, it sometimes can also produce severe adverse effects on body metabolism. This review summarizes the adverse effects of ADT on body composition, the levels of cholesterol and blood glucose, and the cardiovascular system, and the intervention management of these metabolic complications as well.

Efficacy of the traditional Chinese medicine NAOAN capsule for primary prevention of stroke in high-risk population / 中华健康管理学杂志

Objective To evaluate the efficacy of the traditional Chinese medicine NAOAN capsule in primary prevention of stroke in high?risk populations. Methods A multicenter, randomized controlled study was performed in community setting, involving 1 088 individuals at high risk of stroke, with cerebrovascular function scores<75 and 10?year Framingham stroke risk ≥6%. Subjects were recruited in communities at Beijing, Shanghai, Changsha, and Chengdu communities, through resident committees or the village unit. A total of 559 subjects were randomized into a group treated with the NAOAN capsule, and 529 subjects in an aspirin treatment group. Follow?up was performed every 2 months for 2 years. At the mid?point and end of the intervention, we compared cerebrovascular function differences between the 2 groups. Results During the 2?year community trial, 531 subjects in the NAOAN capsule group and 465 in the aspirin group followed the protocol. Cerebrovascular function scores increased from 45.2±19.7 at baseline to 61.7±26.5 after the 2?year trial (t=－12.931, P<0.001) in the NAOAN capsule group, and from 47.2±18.9 at baseline to 53.7 ± 25.1 (t=－5.058, P<0.001) in the aspirin group; greater increases in cerebrovascular function scores were found in the NAOAN capsule group than that in the aspirin group (t=4.906, P<0.001). Conclusions Cerebrovascular function in individuals at high risk of stroke was improved by taking NAOAN capsule. Cerebrovascular function scores improved more with NAOAN capsules than with aspirin.

Analysis on preventive use of antibacterial agents in a tumor hospital from 2011 to 2013 / 中国基层医药

Objective To understand the prophylactic use of antimicrobial agents in the patients undergoing I incision surgery from 2011 to 2013 in a tumor hospital,to explore the the effects of intervention management measure for antibacterial agents using in the perioperative period.Methods The cases of tumor surgical patients of 2011-2013 were selected and divided into the three intervention groups and non-intervention group.The data of medication after three-stage continuous integrated intervention were collected and compared.Results The percentage of antibiotics use was much lower,from 61.73%pre-intervention to 47.03%,26.78%and 24.85%after three stage intervention. The course of preventive medication treatment was significantly decreased from 81h to 53h,33h,21h,respeetively.The reasons of their rationally utilizing antibiotics were significantly improved after intervention management.Conclusion Rational antibiotics utilization can be improved by intervention management during perioperative period of typeⅠinci-sion operations,which can achieve the goal of health department.