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OBJECTIVES: Infertility has a significant impact on a women's quality of life (QOL). Infertile women face with physical and mental challenges during their postmenopausal period. Therefore, the present study aimed to evaluate the QOL among Iranian infertile women in the postmenopausal period using a valid and reliable instrument. METHODS: In this cross-sectional study both snowball and social networking methods were used for sampling. Two demographic and QOL questionnaire were used for data collection. The QOL questionnaire includes 41 items which measure the QOL in five dimensions: socioeconomic, mental health, religiousness, physical health and future imagining. Data analyzed was carried out in IBM SPSS ver. 20.0 using descriptive statistic, χ2 test, and Fisher test. A P value of 0.01 or less was considered significant. RESULTS: Overall 211 eligible participants were studied. Some participants obtained full score on socioeconomic, religiousness, physical health and future imagining dimensions of QOL but none on the mental health dimension of the QOL. Only, 6.6% of study participants have a good QOL. There was a significant relationship between age and financial provider whit status of QOL. CONCLUSION: Most Iranian infertile women in the postmenopausal period have poor or moderate QOL. Therefore, improving the QOL among these women should be considered.
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Femenino , Humanos , Estudios Transversales , Recolección de Datos , Infertilidad , Menopausia , Salud Mental , Posmenopausia , Calidad de VidaRESUMEN
Introduction: Metabolic syndrome (MetS) is defined by indicators of hypertension, abdominal obesity, abnormal lipid profile, and hyperglycaemia. Few studies have investigated the association between serum calcium and MetS. Thus, this study examined prospectively the association between serum calcium in Iranian women with onset of MetS, and key components of MetS. Methods: A total of 460 subjects were recruited, comprising 232 with MetS and 228 as a control group. Waist circumference (WC) and blood pressure (BP) were measured and fasting blood samples were obtained for determination of glucose, insulin, total triglycerides (TGs), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and serum calcium. Results: Compared to the control group, women with MetS had significantly higher WC, BP, TG, glucose, and LDL-C levels but lower HDL-C levels with 97.1±8.4 cm, 123.2±16 mmHg, 219.9±88.7 mg/ dl, 119.208.8 mg/di, 121.3±201 mg/dl, and 38.8±4.9 mg/dl, respectively. Serum concentrations of calcium were significantly higher in women with MetS (9.9±0.3 mg/dl) compared to the control group (9.1±0.7 mg/dl). Serum concentrations of calcium and phosphorus are predictors of MetS. Serum calcium level had a positive association with the risk of having high levels of glucose, TG, BP and WC. Conclusion: Serum calcium level showed a positive association with the risk of having high levels of parameters associated with MetS in the Iranian women studied. More studies on MetS are suggested to include measuring serum calcium as well to verify the present findings.
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Introduction: Metabolic syndrome (MetS) is defined by indicators of hypertension, abdominal obesity, abnormal lipid profile, and hyperglycaemia. Few studies have investigated the association between serum calcium and MetS. Thus, this study examined prospectively the association between serum calcium in Iranian women with onset of MetS, and key components of MetS. Methods: A total of 460 subjects were recruited, comprising 232 with MetS and 228 as a control group. Waist circumference (WC) and blood pressure (BP) were measured and fasting blood samples were obtained for determination of glucose, insulin, total triglycerides (TGs), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and serum calcium. Results: Compared to the control group, women with MetS had significantly higher WC, BP, TG, glucose, and LDL-C levels but lower HDL-C levels with 97.1±8.4 cm, 123.2±16 mmHg, 219.9±88.7 mg/ dl, 119.208.8 mg/di, 121.3±201 mg/dl, and 38.8±4.9 mg/dl, respectively. Serum concentrations of calcium were significantly higher in women with MetS (9.9±0.3 mg/dl) compared to the control group (9.1±0.7 mg/dl). Serum concentrations of calcium and phosphorus are predictors of MetS. Serum calcium level had a positive association with the risk of having high levels of glucose, TG, BP and WC. Conclusion: Serum calcium level showed a positive association with the risk of having high levels of parameters associated with MetS in the Iranian women studied. More studies on MetS are suggested to include measuring serum calcium as well to verify the present findings.
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Background: Breast cancer is one of the most common cancers in Iranian women. The p53 gene plays a principal role in genomic stability, and its function varies according to polymorphisms. The aim of our study was to determine the relationship between the intron3 16bp duplication polymorphism of the p53 gene and breast cancer in Iranian women. Materials and Methods: We performed a case-control study among 145 patients with invasive ductal carcinoma of the breast and 145 controls in Isfahan, Iran. The distribution of the intron3 16bp duplication polymorphism was determined by polymerase chain reaction (PCR). The relationship between clinicopathological data and the PIN3 polymorphism was examined using chi-squared analysis. Results: A significant difference was observed in the polymorphism variants in breast cancer specimens compared with controls (P < .001). Among the cancer patients, 59.9% were below the age of 50 years; and 67.5% of the patients in this group had the intron3 16bp duplication polymorphism. Conclusions: PIN3 Ins 16bp duplication polymorphism is a genetically predisposing factor for breast cancer development in Iranian women and may be causal in patients under the age of 50 years.