RESUMEN
objective To explore the mechanism of Naotaitong granule on ischemic apoplexy by observing the effect of Naotaitong granule on ischemic apoplexy model. Methods128 rats were randomly divided into sham operation group, console group, experimental group and control group. Ischemic apoplexy model were established in all the animals. Different disposal was given to different group. In the 7 d、 10 d、 14 d、21 d and 28 d after drug administration, immunohistochemistry were used to evaluate the expression of Slit2 and VEGF. In addition, behavior alteration and HE staining were applied to evaluate the variation of brain tissue neuron. ResultsAll the animals revealed hemiplegia and cerebral tissue softened after successfully establishing apoplexy model. The morphology of experimental group and control group was improved after drug administration with softened focus obviously reduced. Longa grade of console group in the 7 d、 10 d、 14 d、 21 d and 28 d was (2.92±0.20)、 (2.58±0.20)、 (2.25±0.27)、 (1.83±0.26) and (1.42±0.20) respectively. Longa grade of Naotaitong group in the 7 d、 10 d、 14 d、 21 d and 28 d was (1.92±0.20)、 (1.50±0.32)、 (1.25±0.27)、(0.83 ±0.26) and (0.50±0.00) respectively. Longa grade of control group in the 7 d、 10 d、 14 d、 21 d and 28 d was (2.33±0.41)、 (2.00±0.45)、 (1.75±0.27)、 (1.33±0.41) and (0.92±0.38) respectively. Longa grade of both control and Naotaitong group had statistics significance compared with the console group (P＜0.01) .Conclusion Naotaitong granule may improve anoxemia in rats brain and protect brain tissue.
RESUMEN
Objective To observe the effect of HuaTanTongLuo decoction on ischemic apoplexy of pathogenic wind and phlegm-blood stasis syndrome in the convalescent stage. Methods 57 patients of ischernic apoplexy were randomly recruited in to a control group and a treatment group. The treatment group containing 29 patients was treated with HuaTanTongLuo decoction, and the control group containing 28 patients was treated with XiaoShuanTongLuo capsule. Evaluate the effects after being treated for 8 weeks. Results The score of neurologic impairment evaluation in both groups was obviously improved in both groups (P<0.01) , with the results in the treatment group being better than the control group (P<0.05) . The therapeutic effect of the treatment group was also better than that of the control group (P<0.05). Conclusion HuaTanTongLuo decoction has effects in treating ischemic apoplexy of pathogenic wind and phlegm-blood stasis syndrome in the convalescent stage.