RESUMEN
OBJECTIVE: To study the optimal alcohol extracting technology for Fructus Crataegi in Jiangzhibao capsules and to study its quality control method. METHODS: The content of Hyperoside and the yield of alcohol extract were studied. An orthogonal design of L9( 34) was carried out with concentration, dosage and extracting time of alcohol as three factors, and three levels of each factor were chosen for the experiment. The content of Hyperoside was determined by HPLC. RESULTS: The optimum alcohol extracting procedure was as follows: 70% alcohol was added and the solid-liquid ratio was 1∶ 10, refluxing for 1h. The process The process was repeated once again. The linear range of Hyperoside was 1. 024～ 30. 72? g? mL-1. CONCLUSION: The alcohol extracting technology is reasonable and feasible, and the preparation obtained is controllable in quality.