RESUMEN
Objective: To investigate the effects of Jiaosanxian (JSX, consisted of stir-baked Hordei Fructus Germinatus-Crataegi Fructus-Massa Fermentata Medicinalis) on reducing blood lipid. Methods: The model of hyperlipidemic mice was established by feeding high-fat diet. Kunming mice were randomly divided into six groups: blank, hyperlipidemic, Zhibituo, low-, mid-, and high-dose [100, 200, and 400 mg/(kg·d)] JSX groups, and were continuously ig administered for 28 d. The contents of total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and high density lipoprotein cholesterol (HDL-C) in serum and liver and liver index were determined. Results: The contents of TC, TG, and LDL-C in serum or liver were decreased significantly but the contents of HDL-C were increased more significantly in the mid- and high-dose JSX groups than those in hyperlipemic group. The weight and liver index were decreased significantly with the dose increasing of JSX. The lipid-decreasing effects were improved with the dose increasing. Conclusion: These results suggest that JSX has the significant effects on hyperlipidemia. It could provide the experimental basis for the clinical use of JSX for the treatment of hyperlipidemia. © 2013 Tianjin Press of Chinese Herbal Medicines.