Interactive effects of ATOH7 and RFTN1 in association with juvenile primary open-angle glaucoma / 国际眼科杂志(Guoji Yanke Zazhi)

@#AIM:To study <i>ATOH</i>7 and <i>RFTN</i>1 sequence variations in patients with juvenile primary open-angle glaucoma(JOAG). <p>METHODS: In 298 controls(age≥60y)and 52 JOAG(age<35y), we collected samples from the patients and controls of study, extracted the DNA, and then the single exon of <i>ATOH</i>7 was sequenced by direct sequencing. Additional single nucleotide polymorphisms the RFTN1 SNP(rs690037)and at upstream <i>ATOH</i>7(rs1900004 and rs3858145)were genotyped by Taqman assay. <p>RESULTS: No any coding mutation was detected in JOAG. There were no significance in allele frequencies and haplotypes between JOAG and control group of rs7916697, rs61854782, rs1900004、rs3858145 and rs690037, so no SNP was associated with JOAG(<i>P</i>>0.05). <p>CONCLUSION: Although preliminary study has showed combination of <i>ATOH</i>7 and <i>RFTN</i>1 SNPs could increase the risk of getting adult-onset primary open angle glaucoma, <i>ATOH</i>7 and <i>RFTN</i>1 are not associated with juvenile primary open-angle glaucoma in this study, so different types of open-angle glaucoma may be differences in genetic mechanism and be worthy of further study.

A Case of Decompression Retinopathy after Glaucoma Surgery

PURPOSE: Acute decompression of the eye in patients with high intraocular pressure (IOP) can lead to development of posterior pole hemorrhages. The courses of this rare syndrome is relatively benign. Herein we report a case of decompression retinopathy that developed diffuse retinal hemorrhages after glaucoma surgery in both eyes. METHODS: A 17-year-old male patient diagnosed with juvenile primary open angle glaucoma (JPOAG) underwent glaucoma surgery on both eyes at five months interval. Visual acuity on presentation was no light perception (NLP) in the right eye and 1.0 in the left eye. On the first postoperative day, IOP was 4 mmHg and diffuse retinal hemorrhages was found in the posterior pole after nonperforating trabecular surgery and triangular reticulated sodium hyaluronidate (SK GEL 3.5) implantation in the right eye. Trabeculectomy with 0.02% mitomycin C soaking (1 minute) was performed in the left eye 5 month after the right eye operation. On the second postoperative day, IOP was 5 mmHg and diffuse retinal hemorrhages was also observed in the posterior pole of the left eye. During the follow-up period (8 weeks), the retinal hemorrhage was absorbed without impairment of visual acuity. RESULTS: Decompression retinopathy developed in the posterior pole of the patient with JPOAG after glaucoma surgery, and the hemorrhages were absorbed over time with no visual impairment.

Initial Mitomycin C Trabeculectomy in Young Patients

Antimetabolites that inhibit postoperative fibroblast proliferation increases the success of glaucoma filtration surgery. However, the use of mitomycin C in young patients has not been extensively studied. The effectiveness of initialtrabeculectomy with mitomycin C or uncomplicated glaucoma in patients age 40 years or younger was evaluated in a consecutive series of 15 eyes of 10 patients. Thirteen eyes had juvenile primary open-angle glaucoma and 2 eyes had steroid induced glaucoma. Mitomycin C (0.002%) was applied for 2 to 4 minutes during the surgery. The success rate was evaluated with Kaplan-Meier analysis, and it was 78% at postoperative 9 months. Complications included postoperative hyphema(7 eyes), hypotony (2 eyes), and bleb-related endophthalmitis.