RESUMEN
Objective To explore the clinical effects of flurbiprofen axetl injection on the treatment of postoperative pain in patients with laparoscopic appendectomy and on the platelet aggregation function.Methods From April 2013 to October 2015,100 laparoscopic appendectomy patients were randomly divided into observation and control groups,50 cases in each group.Observation group was injected flurbiprofen axetl injection 1 mg/kg,the control group was injected normal saline 5 ml.Analgesic effect,platelet aggregation function,and side effect were observed for two groups.Results Activities and resting visual analogue scale (VAS) score were significantly lower after flurbiprofen axetl injection in observation group (P ＜ 0.01),while activities and resting VAS score were not significantly decreased after normal saline used (P ＞ 0.05).Compared to those in control group,activities and resting VAS score at 30 min,1 h,2 h,4 h,and 6 h after flurbiprofen axetl injection in observation group were significantly lower (P ＜0.01).Platelet aggregation level before and after medication in two groups were no significant change (P ＞ 0.05).Drug side effects in two groups were no difference (P ＞ 0.05).Conclusions Patients with laparoscopic appendectomy do well with flurbiprofen axetl injection,and no obvious side effects.It is worthy of clinical application.
RESUMEN
Objective To study the flurbiprofen axetil (FA) for postoperative analgesia of gynecological laparoscopic surgery and the changes of interleukin-6 in blood.Methods80 cases were selected for gynecologic laparoscopic surgery,the patients were randomly divided into 4 groups with 20 cases each group.Group A was given FA 50 mg and tramadol 1 mg/kg 30 minutes before the end of surgery.Group B was given FA 50 mg 5 minutes before induction of anesthesia and given tramadol 1 mg/kg 30 minutes before the end of surgery,and group C was given FA 50 mg five minutes before induction of anesthesia.Group D was given tramadol 2 mg/kg 30 minutes before the end of surgery.After the surgery,the VAS was observed in real-time of wake up (T1),and 2 hours (T2),6 hours (T6) and 24 hours (T24) after operating.The blood of each group was taken at the different time points including arriving in the room (T0),waking up (T1) and 6 hours (T6) after operating.The blood samples were hold for 30 minutes and centrifuged (3000 r/min,10 min),and IL-6 was detected using double-antibody sandwich ABC-ELISA.ResultsThe experiments showed that VAS in T1 time point of group A,B,C were lower than that of group D(1.40±0.26,1.67±0.37,1.60±0.42 vs 3.13±2.32).In T24 time point,VAS of group A,B were also lower than that of group D(2.13±1.24,2.00±1.25 vs 3.53±1.87),the differences were significant (P＜0.05).The experiments showed that concentration of IL-6 in group D was higher than that in group A,B,C at the T1 time point (12.26±6.56 vs 2.94±2.55,3.37±2.43 vs 2.93±1.16,P＜0.05).ConclusionsThe postoperative analgesic effect of Flurbiprofen axetil combined with tramadol on the ogynecological laparoscopic was superior to using any of the drug alone.Flurbiprofen axetil could inhibit increasing of IL-6 and have an effect against the inflammatory response induced by surgical trauma,and it has a good analgesic effect.