RESUMEN
Objective: To investigate the chemical constituents in soft coral Lobophytum sp. collected from the Xisha islands of China. Methods: Compounds were isolated and purified by column chromatographies on silica gel, reversed-phase silica gel (ODS), Sephadex LH-20, and high performance liquid chromatography (HPLC). Their structures were identified on the basis of physicochemical properties and spectroscopic methods. Results: Five compounds were isolated and identified as 11,12-epoxy-sarcophytonin E (1), cholest-5,22-dien-3β-ol (2), honulactone A (3), sarcophytonone (4), and 3-dehydroxyl-20-acetylpresinularolide B (5). Conclusion: Compound 1 is a new compound named as chiloboterpene A. Compounds 2-4 are obtained from the soft coral Lobophytum sp. for the first time.
RESUMEN
Objective: To study the chemical constituents of a kind of soft coral Lobophytum sp. collected from Xisha islands of China. Methods: Isolation and purification of the chemical constituents were performed by silica gel and ODS gel column chromatographies as well as HPLC. Their structures were determined on the basis of physicochemical properties and spectroscopic methods. Results: Six diterpenoids were obtained in 95% ethanol extract from Lobophytum sp., including chilobolide B (1), (1S*,3S*,4S*,7E,11E)-3,4-epoxy-13-oxo-7,11,15-cembratriene (2), (2E,4E,7R,8S,12Z)-1-isopropylcyclotetradeca-4,8-dimethyl-7-hydroxy-1,3,11-triene-8,12-carbolactone (3), (2E,4E,8S,12Z)-1-isopropyl-4,8-dimethyl-7-oxocyclotetradeca-l,3,11-triene-8,12-carbolactone (4), sarcrassin D (5), and laevigatol B (6). Conclusion: Compound 1 is a new compound named chilobolide B. Compounds 2-4 are obtained from Lobophytum sp. for the first time.