RESUMEN
OBJECTIVE: To detect the levels of B cell activating factor(BAFF) in cerebrospinal fluid(CSF) in patients with lupus encephalopathy(LE). METHODS: CSF from 15 patients with LE and 11 controls with headache were collected. The controls with headache were excluded diseases at last and used to be controls. The levels of BAFF were measured by enzyme-linked immunosorbent assay(ELISA). Clinical features and laboratory data were collected from the patients with LE. RESULTS: The levels of BAFF in the CSF of patients with LE were significantly higher than that of controls [(1421.3±670.31) pg/mL vs.(21.9±21.44) pg/mL, P<0.01]. The levels were also increased significantly when compared with paired sera[(1011.4±356.43) ng/L, P<0.05]. CONCLUSION: was not found between the levels of BAFF and serum BAFF as well as the other clinical items. CONCLUSION: Brain immunity may contribute the increased BAFF in CSF in patients with LE.
RESUMEN
OBJECTIVE:To observe the efficacy and safety of breviscapine combined with double shock in the treatment of lu-pus encephalopathy. METHODS:70 patients with lupus encephalopathy were randomly divided into control group and observation group. Control group was treated with Methylprednisolone sodium succinate for injection 500 mg for continuous 3 d,iv,once a day,Cyclophosphamide for injection 1.0 g in the 4th day,iv,and Methylprednisolone sodium succinate for injection 80 mg was used for maintaining treatment in the 5th day for continuous 15 d,once a day. Observation group was treated with Breviscapine for injection 50 mg for continuous 20 d based on the treatment of control group,iv,once a day. The SLE activity(SLEDAI) score, IL-1β,IL-6,IL-8 and IFN-γ were observed,cases of neurological and psychological symptoms,the fatality rate and incidence of adverse reactions were recorded. RESULTS:After treatment,the SLEDAI,IL-1β,IL-6,IL-8 and IFN-γ in 2 groups were signifi-cantly lower than before,and observation group was lower than control group(P0.05). CONCLU-SIONS:Breviscapine combined with double shock has good efficacy and safety in the treatment of lupus encephalopathy,it can re-duce the SLEDAI score,improve neurological and psychological symptoms.