A new norclerodan diterpene from twigs and leaves of Croton euryphyllus / 中草药

To study the diterpenoids from the twigs and leaves of Croton euryphyllus. Methods Compounds were isolated and purified by column chromatography on silica gel, MCI, and semi-preparative HPLC, and their structures were elucidated by spectroscopic analysis and comparisons with published literature values. Results Four compounds were obtained from the petroleum ether fraction of 95% alcoholic extract of the twigs and leaves of C. euryphyllus, and structures were identified as crotoeurin D (1), mallotucin C (2), mallotucin D (3), and plaunotol (4), respectively. Conclusion Compound 1 is a new norclerodan diterpene. Compounds 2-4 are isolated from this plant for the first time.