RESUMEN
Node negative breast cancer is a prevalent form of breast cancer .With the improvement of breast cancer screening and disease awareness ,the rates of node negative breast cancer are gradually increasing . Although node negative breast cancer patients have much lower recurrence rates as compared with node positive patients,node-negative breast cancer is unequal to a low risk disease .Thus,it is important for oncologist to esti-mate the risk factors of node negative disease ,to carry out risk assessment and to guide the best regimen for these patients.In current review ,we discuss the value of traditional prognostic factors and new prognostic factors ,such as the urokinase -type plasminogen activator/plasminogen activator inhibitor 1,oncotype DX,MammaPrint and tumor associated macrophages ,on the predictive and treatment decisions in node negative breast cancer .
RESUMEN
El objetivo del presente trabajo es reportar nuestra experiencia con la utilización del Mammaprint. Analizando los resultados de 16 pacientes, los cuales cumplieron con los criterios de selección establecidos. En 56,25 por ciento la prueba fue reportada como insuficiente, 25 por ciento como de alto riesgo y 18,75 por ciento bajo riesgo. 75 por ciento de las pacientes fueron mayores de 50 años. En estas pacientes no se identificaron tumores de alto riesgo, mientras que en menores de 50 años el 50 por ciento de los tumores correspondían al grupo de alto riesgo. En 62,5 por ciento de las pacientes la lesión era menor de 10 mm (T1b), mientras en 37,5 por ciento correspondían al grupo T1c. En el grupo de pacientes de bajo riesgo, no se identificaron ganglios axilares, por el contrario en 50 por ciento de las pacientes con alto riesgo si se identificaron y en consecuencia se realizó una punción con aguja fina, con resultado negativo para metástasis. En ninguna de las 3 pacientes del grupo de bajo riesgo se identificaron metástasis en la evaluación histológica posoperatoria, sin embargo, en 75 por ciento del grupo de pacientes de alto riesgo si se identificaron metástasis a los ganglios axilares. La determinación de las características genéticas y sus alteraciones en un cáncer de mama, es de fundamental importancia para una mejor identificación de los grupos de bajo y de alto riesgo y para determinar los mejores tratamientos
The objective of this work was information of genetic characteristics of tumor, determined by methods such as mamma print identifies more adequately the risks and treatments for patients. In this work we report our experience with the use of mamma print. Analyzing the results of 16 patients whom met the selection criteria. 56.2 5 percent of the cases were in the test reported insufficient, 25 percent high risk and 18.75 percent low risk. 75 percent of patients were older than 50 years. In these patients were not identified high-risk tumors, mean while in patients less than 50 years 50 percent of the tumors corresponded to the high risk group. In 62.5 percent of patients the lesion was less than 10 mm (T1b), while 37.5 percent were T1c group. In the group of low risk patients, axillaries nodes were not identified to the US, by contrast 50 percent of patients at high risk were identified and accordingly a fine needle punting was performed, with results negative for metastases. In none of the patients in low-risk & group metastases was identified in the postoperative histological evaluation, however in 75 percent of the group of at high risk patients was identified axillaries node metastases. Determining of the characteristics and genetic alterations in breast cancer has fundamental importance for a better identification of groups of low and high risk and to determine the best treatments