RESUMEN
The paper deals with the scientifically based composition of a new food supplement. The specialized productimproves metabolism in people with nervous system disorders, its ingredients having a synergetic effect. Onetablet of the food supplement contains, mg: Gotu Kola (fruit) – 50 , L-glutamine acid - 50, motherwort - 25,lecithin - 25, gamma-aminobutyric acid - 25, calcium carbonate - 25, magnesium oxide - 25, choline bitartrate -20, guarana - 16.5, ginkgo biloba (extract) - 15, hawthorn (fruit) - 15, ginseng (root) - 13, inositol - 8, Lmethionine - 8, L-tyrosine - 7.5, L-phenylalanine - 7.5, L-caratin - 5, vitamin B3 - 5, B5-2.5, DNase - 4, RNase -4, vitamin B6 - 1, vitamin B1 - 0.5, folic acid - 0.2, vitamin B12 - 00005. The authors provide biochemicalcharacteristics of the supplement active substances to establish its functional properties and regulated qualityindicators, including nutritional value, as well as a possible mechanism of metabolism normalization. The safetycriteria comply with regulatory documents requirements, which have been proved by sanitary-hygienic andsanitary-toxicological studies.The functional properties of the specialized product and its efficacy are confirmed by conducting field trialswith a representative group of patients with angioneurosis. Taking two tablets (recommended daily dose)provides the body with the following nutrients intake (in parentheses - percentage of the recommended dailyintake): vitamin B1 – 1mg (67%); Vitamin B3 - 10 mg (50%); Vitamin B5 - 5 mg (100%); Vitamin B6 - 2.0 mg(100%); Vitamin B9 - 0.4 mg (200%); vitamin B12 - 0.001 mg (30%); magnesium - 30 mg (8%), flavoneglycosides (quercetin, campherol, isorhamnetin) - 2 mg (6%). The product composition and manufacturingtechnology have been tested and implemented at the enterprises of the company ArtLife (Tomsk), which arecertified following the requirements of the international standards of the ISO 9001, 22000 series, and GMPrules. That ensures product quality and functional properties stability.
RESUMEN
The prescription composition and the technology of a new type of specialized product - biologically active additive BAAhave been scientifically grounded. The pharmacological properties and functional orientation of the active principles of theformulation components of the dietary supplements were studied, which made it possible to determine the quantitative andqualitative composition of the formulation which has a synergistic effect on metabolic processes in the presence ofdeforming osteoarthrosis: bamboo extract, glucosamine and chondroitin, aloe vera extracts, leaves and grape seeds, vitaminand mineral composition with green tea extract, and the antioxidant complex "Cifrol-5". A production technology providinghigh consumer performance for the developed product was approved. Clinical trials involving two groups of women aged44-49 with deforming osteoarthritis of the knee joints confirmed the functional properties of the complex. The first groupreceived the BAA, the second was a control group. Changes in the control indicators were registered after dietary therapyor in clinically significant periods of patient recovery. The control indicators were joint soreness, skin, hair, and nailcondition, and the recovery time of postoperative sutures. The complex application of diet therapy and the basic treatmentfor dystrophic joint diseases and the rehabilitation measures of the postoperative period were shown to be effective. Inpatients, joint pain and pain index decreased, the fragility of nails and hair was reduced, the microcirculation of the nail bedimproved, and the healing time of the surgical sutures decreased. The consistency of quality indicators and consumerperformance was ensured by production certifications for the developed products within the requirements of internationalstandards of the ISO 9001 and 22000 series and GMP rules.
RESUMEN
Objective To explore the role of computer-aided design and manufacturing technology (CAD/CAM technology) in the repair of mandibular defects using the fibular osteomyocutaneous free flap.Methods Eight patients with a portion of mandible defect due to various reasons were subjected to preoperative CT scan,obtaining CT data of the mandible and the fibular bone to be transplanted.The original and the reconstructed skull model,as well as the mandible and fibula osteotomy guide plates,was printed using CAD/CAM technology.The titanium plates were preformed using the reconstructed skull model,and the operation was performed with the help of guide plates and a preformed titanium plate.The patients were followed up for 6 to 24 months to evaluate the operation effect.Results Two in 8 cases had flap necrosis caused by immune rejection of the implant,and one case had flap necrosis due to poor postoperative blood glucose control.The other 5 patients healed at the primary site and the fibular myocutaneous flap survived well.There were no serious complications in the donor and recepient site.The patients' satisfaction was high.Conclusions The reconstruction of mandible with the aid of CAD/CAM technique has the advantages of accelerating the operation process,shortening the operation time,improving the accuracy of mandibular amputation and fibular shaping,promotlng postoperative function and morphology recovery.
RESUMEN
Oral delivery is currently the gold standard in the pharmaceutical industry where it is regarded as the safest, most convenient and most economical method of drug delivery having the highest patient compliance. Fast dissolving tablets (FDTs) have received ever-increasing demand during the last decade, and the field has become a rapidly growing area in the pharmaceutical industry. Upon introduction into the mouth, these tablets dissolve or disintegrate in the mouth in the absence of additional water for easy administration of active pharmaceutical ingredients. The popularity and usefulness of the formulation resulted in development of several FDT technologies. Fast- or mouth dissolving tablets have been formulated for pediatric, geriatric, and bedridden patients and for active patients who are busy and traveling and may not have access to water. This review describes the various formulation aspects, disintegrants employed and technologies developed for FDTs, patent formulation, evaluation tests, and marketed formulations.