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Objective:To investigate the effect of multi-sensory stimulation therapy on agitation behavior in patients with Alzheimer's disease(AD).Methods:A total of 45 patients with AD hospitalized in the Department of Neurology of Xuanwu Hospital, Capital Medical University, from June 2021 to January 2022 were selected, including 23 cases in the control group and 22 cases in the experimental group. The control group was treated with routine nursing methods, and the experimental group was treated with multi-sensory stimulation. The scores of Cohen-Mansfield Agitation Inventory (CMAI) and Behavioral Pathology in Alzheimer′s Disease Rating Scale (BEHAVE-AD) were compared between the two groups before and after treatment.Results:CMAI comparison showed that after the intervention, the CMAI scores of the experimental group and the control group was 33.14 ± 3.72 and 37.13 ± 7.23 respectively. The difference was statistically significant ( t=-2.34, P<0.05). The total score of "physical non aggressive behavior" and "language non aggressive behavior" in the experimental group were (11.09±2.91), (5.73±2.16), which were lower than those in the control group (13.57±4.33), (8.22±2.71). The differences were statistically significant ( t=-2.26,-3.39, P<0.05). The BEHAVE-AD scores of the experimental group before and after the intervention were (13.14 ± 9.54), (9.50 ± 4.81), in the control group were (11.04 ± 8.34), (10.70 ± 9.81). There was significant difference in BEHAVE-AD score before and after the intervention in the experimental group ( t=2.21, P<0.05), but there was no significant difference compared with the control group ( t=-0.73, P>0.05). "Behavior disorder" of the experimental group improved significantly after the intervention, and the score was (2.41 ± 1.26) compared with the control group (4.48 ± 2.87), the difference was statistically significant ( t=-3.10, P<0.05). Conclusions:Compared with routine nursing, visual + auditory + tactile multi-sensory stimulation can improve the agitation behavior of AD patients, especially non aggressive agitation behavior, which has certain clinical significance and can provide reference for future related research.
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Objective To investigate the effects of multisensory stimulation on mental behavioral symptoms and health-related quality of life in patients with Alzheimer's disease (AD).Methods From March 2018 to August 2018,159 AD patients (65-75 years old) in neurology and psychiatric clinic of the Second Affiliated Hospital of Fujian Medical University were enrolled.Randomized grouping was performed by randomized software,experimental group (multi-sensory stimulation),81 cases,control group (no intervention),78 cases.The experimental group had a multi-sensory stimulation for 16 weeks,twice a week,40 minutes each time,for a total of 32 times.At the time of enrollment and 16 weeks after the intervention,the simple neuropsychiatry scale (NPI-Q) and the health-related quality of life questionnaire (HRQLS) were filled out.The t-test and two-factor repeated measures analysis of variance were used to analyze the data.Results The NPI-Q scores of the two groups before and after intervention were compared by two-factor repeated measurement ANOVA.There was no significant difference in NPI-Q average score between the expermental group(2.20±0.22) and control group(2.17±0.35) before intervention (t=0.53,P=0.595).After intervention NPI-Q average score of the experimental group(2.17±0.46) was lower than that of the control group (1.71±0.29) (t =7.56,P＜ 0.01).The intervention effect (F=50.77,P＜ 0.0 1),the time effect (F=39.20,P＜0.01) and interaction effect (F=33.89,P＜0.01) were statistically significant.The HRQLS scores of the two groups before and after intervention were compared by two-factor repeated measurement ANOVA.The intervention effect(F=140.82,P＜0.01),the time effect (F=56.64,P＜0.01) and interaction effect (F=60.38,P＜0.01) were statistically significant.Conclusion Multisensory stimulation can improve mental behavioral symptoms in patients with Alzheimer's disease and improve health-related quality of life.
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OBJECTIVE: To evaluate the effect of multiple sensory stimulation on cortical excitability by using transcranial magnetic stimulation (TMS). METHOD: Thirteen right handed young adults without neurological deficit were enrolled. Cortical excitability was tested by measuring recruitment of motor evoked potentials [recruitment curve (RC)], intracortical inhibition (ICI), and intracortical facilitation (ICF) at the abductor pollicis brevis of the dominant hand in two different conditions: (1) group A: active thumb and index finger pinch movement while observing the congruent finger movement in a screen with 0.2 Hz bell sound for 30 minutes, (2) group B: the same active finger movement in a dark screen with the same bell sound for 30 minutes. All of these procedures were done with a randomized crossover design. RESULTS: The amplitude of MEP and the slope of all RC (140%,160% of the resting motor threshold) of group A showed increment after visually-guided finger movement and the level of ICI showed decrement after visually guided finger movement (p0.05) in group A. In group B, the amplitude of MEP and the levels of ICI, ICF showed no significant changes following finger movement with no visual guidance (p>0.05), but the slope of RC with 140% showed increment (p<0.05). CONCLUSION: These findings suggest that cortical excitability can be enhanced by simple repetitive motor practice. The congruent sensori-motor stimulations lead to corresponding additional effect on cortical excitability, presumably by recruitment of remote motor neurons.