Pancreatoduodenectomy for solid pseudopapillary tumor of the pancreas: a multi-institution study / Duodenopancreatectomia para o tumor pseudopapilar sólido do pâncreas: estudo multi-institucional

ABSTRACT Background: Solid pseudopapillary tumor of the pancreas is a rare low-grade malignant neoplasm. Most patients present with nonspecific symptoms until the tumor becomes large. Complete surgical resection by pancreatoduodenectomy is the treatment of choice for tumors located in the head of the pancreas Aim: To analyzed the clinicopathologic features, management, and outcomes of patients who had solid pseudopapillary tumor of the head pancreas and underwent surgical resection. Methods: Were analyzed 16 patients who underwent pancreatoduodenectomy for this condition. Results: Mean age was 25.7 years old, and 15 patients were female (93.7%). Nonspecific abdominal pain was present in 14 (87.5%). All underwent computed tomography and/or magnetic resonance imaging as part of diagnostic workup. The median diameter of the tumor was 6.28 cm, and surgical resection was performed with open or laparoscopic pancreatoduodenectomy without neoadjuvant chemotherapy. Postoperative complications occurred in six patients (37.5%) and included pancreatic fistula without mortality. The mean of hospital stay was 10.3 days. Median follow-up was 3.6 years, and no patient had local recurrence or metastatic disease. Conclusion: For these patients surgical resection with pancreatoduodenectomy is the treatment of choice showing low morbidity, no mortality, and good long-term survival.

RESUMO Racional: Tumor sólido pseudopapilar do pâncreas é neoplasia maligna rara, de baixo grau de malignidade. A maioria dos pacientes apresenta sintomas inespecíficos até que o tumor aumente de tamanho. A ressecção cirúrgica completa através a duodenopancreatectomia é o tratamento de escolha para os localizados na cabeça do pâncreas. Objetivo: Analisar as características clinicopatológicas, tratamento e resultados de pacientes com tumor sólido pseudopapilar do pâncreas localizado na cabeça do pâncreas submetidos à ressecção cirúrgica. Método: Foram analisados 16 pacientes com duodenopancreatectomia devido a esse tumor localizado na cabeça do pâncreas. Resultados: Havia 15 mulheres (93,7%) e a média de idade era de 25,7 anos. Dor abdominal não específica esteve presente em 14 pacientes (87,5%). Todos realizaram tomografia computadorizada do abdome e/ou ressonância nuclear magnética como parte da investigação. O diâmetro médio do tumor era de 6,28 cm e a ressecção cirúrgica foi realizada por duodenopancreatectomia, tanto por laparotomia quanto por videolaparoscopia, com ou sem quimioterapia neoadjuvante. As complicações pós-operatórias ocorreram em seis pacientes (37,5%) e incluíram fístula pancreática, sem mortalidade. O tempo médio de internação hospitalar foi de 10,3 dias. O tempo médio de seguimento foi de 3,6 anos e nenhum paciente apresentou recorrência local ou doença metastática. Conclusões: A ressecção cirúrgica através da duodenopancreatectomia é o tratamento de escolha para estes pacientes. Os resultados mostraram baixa morbidade, nenhuma mortalidade e boa sobrevida em longo prazo.

Neoplasia sólida pseudopapilar del páncreas / Solid pseudopapillary tumor of the pancreas

Antecedentes: la neoplasia sólida pseudopapilar (NSSP) del páncreas es un raro tumor pancreático que se da comúnmente en mujeres jóvenes. Por lo general, son poco sintomáticos y el pronóstico es bueno ante cirugía resectiva. Objetivo: describir 6 casos tratados en 3 centros diferentes y hacer una revisión actualizada del tema. Material y métodos: análisis de historias clínicas, biopsias y protocolos quirúrgicos. Período enero de 2014 hasta abril de 2017. Resultados: encontramos 6 casos (5 mujeres y 1 hombre); el promedio de edad fue 39,7 años (rango 28 a 54 años). En 3 casos se trató de hallazgos incidentales. En todos los casos se utlizaron Ecografia y tomografia computarizada (TC) para el diagnóstico y en 2 casos se realizó resonancia magnética (RM). Todos los tumores se encontraron en el cuerpo o la cola del páncreas o en ambos. En 2 cirugías se realizó un abordaje videolaparoscópico; el tempo quirúrgico promedio fue de 91,17 minutos y el promedio de días de hospitalización fue de 5,5, con 3 pacientes que reingresaron por complicaciones durante el posoperatorio (un absceso y 2 fistulas pancreáticas). Conclusiones: se trata de tumores poco frecuentes; sin embargo, creemos que el avance en métodos por imágenes permitrá aumentar el diagnóstico y tratamiento de esta patología por lo que su incidencia aumentará. Queremos destacar la importancia del abordaje videolaparoscópico para este tpo de patología, ya que en la mayoría de los casos resulta factible con buenos resultados. Estas cirugías deben realizarse en centros donde puedan manejarse sus complicaciones para evitar reintervenciones.

Background: Solid Pseudopapillary Neoplasia (NSSP) pancreas is a rare pancreatic tumor commonly found in young women. They are usually not very symptomatic and the prognosis is good in resective surgery. Objective: to describe 6 cases from 3 diferent centers and to make an updated review of the topic. Materials and methods: analysis of clinical histories, biopsies and surgical protocols. Period from January 2014 to April 2017. Results: we found 6 cases, with 5 women and 1 male; the mean age was 39.7 years (range 28 to 54 years). In 3 cases we dealt with incidental findings. In all cases, echography and CAT were used for the diagnosis and in 2 cases, MRI was performed. All tumors were found in the body and / or tail of the pancreas. In 2 surgeries a videolaparoscopic approach was performed, the mean surgical tme was 91.17 minutes and the mean number of days of hospitalizaton was 5.5, with 3 patents reentered for postoperative complicatons (one abscess and two pancreatic fistulas). Conclusions: these tumors are rare; however we believe that the advances in imaging methods will increase the diagnosis and treatment of this pathology so that its incidence will increase. We want to emphasize the importance of the videolaparoscopic approach for this type of pathology since in most cases it is feasible with good results. These surgeries should be performed in a center where their complicatons can be managed to avoid reinterventons.