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Objective: To observe the clinical efficacy of Jin's three-needle therapy on post-stroke cognitive impairment (PSCI) and the effect on neuroelectrophysiology (event-related potentials). Methods: A total of 60 PSCI patients were selected and divided into a treatment group and a control group according to the method of random number table, with 30 cases in each group. The patients in the control group received routine treatment while the patients in the treatment group received additional Jin's three-needle therapy. The treatment for both groups lasted four weeks. Mini-mental state examination (MMSE) and Montreal cognitive assessment (MoCA) scores as well as amplitude and latency of potential 300 (P300) were adopted to compare the between-group results before and after treatment. Results: Before treatment, there were no significant differences (all P>0.05) in MMSE and MoCA scores, P300 latency and P300 amplitude between the two groups. After 4 weeks of treatment, the MMSE and MoCA scores and P300 amplitudes were improved in both groups, and the P300 latencies became shorter. The results showed significant intra-group and between-group differences (all P<0.05). Conclusion: Based on the routine treatment, Jin's three-needle therapy is effective for PSCI. The mechanism is probably through its regulation on the patients' neuroelectrophysiology.
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Objective To explore the probability to unify the scores of different neuropsychological scales under the guideline of item response theory (IRT).Methods Two hundred and three old individuals with a mean age of (80.86±9.52) years were enrolled in this study,including 101 normal individuals and 102 patients with mild cognitive impairment (MCI).The data of cognitive ability assessed using MoCA and MMSE scales were collected and analyzed according to IRT with Stata 14.0 software.The population,qualitative data,and scaled data were analyzed by Hybrid model,2PL model,and GRM model,respectively.Finally,model fitting was conducted in these data.We used test characteristic curves(TCC)to calculate corresponding theta values of the scores of MMSE and MoCA,and draw cartograms after fitting the model.Results The data of MoCA and MMSE conformed to the characteristics of unidimension.The scores of MoCA and MMSE were 26.37 ±2.63 and 29.06±1.32,respectively,in the normal group,and those were 21.57±3.47 and 26.62± 2.89,respectively,in the MCI group.The Log likelihood for the fitting model of MoCA and MMSE was-1 670.9012 and-773.9797,respectively.The TCC indicated that the score of MoCA was lower than that of MMSE at the same level of theta value.The TCC of the two scales were both steep at first,and then became flat.In evaluating the cognition ability,the MoCA score was more precise than MMSE score,and MMSE score was easier to show ceiling effect than MoCA score.Conclusions Under the guideline of item response theory,we can unify the scores of two scales in order to make the scores of two scales fit with each other and be in common use during study and research.
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Objective To explore the impact of low frequency repetitive transcranial magnetic stimula tion (rTMS) on executive dysfunction after stroke by magnetic resonance spectroscopy (MRS) and neuropsychological scale.Methods 60 stroke patients with executive dysfunction were recruited and randomly divided into a study group and a control group,with 30 in each.The study group was treated with rTMS in addition to routine treatment,while the control group received routine treatment only.Before and after treatment,the neuropsychological scale and MRS were measured in both groups.Results After treatment,the scores on the LOTCA and FAB of neuropsychological scale in the treatment group were (87.10 ± 3.16) and (11.97 ± 0.48),significantly better than before the baselines.NAA/Cr was (1.64 ± 0.08) and Cho/Cr was (1.17 ± 0.07),which were significantly better than the baselines.In the control group,significant differences were also observed in the scores of the neuropsychological scale and in the indicators of MRS before and after treatment.Conclusions rTMS can effectively improve executive function in patients with cerebral apoplexy by influencing the metabolites related with cognitive function in the brain.Magnetic resonance spectroscopy can show the therapeutic effect at molecular level.