RESUMEN
Background: Diabetes mellitus is a disease caused by an inability of the body to metabolize glucose properly. The prevalence of diabetes is rapidly rising all over the globe at an alarming rate. As Insulin and non-insulin dependent diabetes shows their effect on various physiological systems includes central, peripheral and autonomic nervous systems, musculoskeletal, cardiovascular and other vital systems. A common complications due to the IDDM and NIDDM includes peripheral neuropathy, retinopathy, nephropathy and vascular complication. Insulin and non-insulin dependent diabetes mellitus, both affect the peripheral nervous system significantly. Therefore we would like to find out neurophysiological changes on peripheral nervous systems between insulin and non-insulin dependent diabetes mellitus. Aim: To find out the Neuro-physiological changes between IDDM and NIDDM. Materials and Method: 120 individuals screened with SF36 (general health good and above) were included with age limit between 25 to 60 years. Those individuals having a history of hospitalization in last 1 year, acute fever, present history of radiculopathy and open wound were excluded. They were divided into 2 groups IDDM and NIDDM. For nerve conduction study–distal latency, amplitude and NCV of sensory and motor nerves were performed. Nerve conduction studies of common peroneal, tibial and sural nerves were examined in both groups. Latency, NCV and CMAP/SNAP were taken as outcome measures. Result and Discussion: Bio-statistical analysis has been done using Mann-Whitney test. Result suggest that there is a significant difference in Neurophysiological changes (p<0.05) between IDDM and NIDDM groups. Conclusion: In context to our study and neurophysiological findings, individuals with IDDM must be taken into consideration for promotion, prevention, and care as compared to NIDDM for secondary complications.
RESUMEN
Seishin-Renshi-In (TJ-111) (Qing-Xin-Lian-Zi-Yin) was administered to seven patients with non-insulin-dependent diabetes mellitus (NIDDM). Five years treatment with TJ-111 was three male patients, three years was one female patient, and two years was two female patients. All of them received 7.5g of TJ-111 per day, 30 minutes before every meal. Body weight and HbA<sub>1</sub> were examined and recorded at intervals during the whole period of administration.<br>Patients whose HbA<sub>1</sub> was increased by more than 8% transiently showed the increases of body weight. It was proved that it is important to keep the calorie intake at an appropriate level and to exercise every day for adjusting body weight even in the treatment of Kampo medicine. The patients who decreased body weight by daily training were considered to be “Kyo-Sho”, and it is suggested to administer Seishin-Renshi-In for the treatment of NIDDM in the concept of Kampo medicine. No side effects were recognized in any cases of treatment with Seishin-Renshi-In.