A Case of Aggressive T/NK-cell Lymphoma/leukemia with Cutaneous Involvement / 대한피부과학회지

Non-nasal T/NK-cell lymphomas(TNKCL) are further subdivided into primary cutaneous and 4 subtypes of secondary cutaneous lymphomas such as nasal type, aggressive, blastic(blastoid), and other specific NK-like T-cell lymphoma. Aggressive T/NK-cell lymphoma/leukemia(ATNKCL) is a rare leukemic variant of nasal type TNKCL. Although ATNKCL invariably exhibits the identical histomorphological, genotypical and immunophenotypical findings with TNKCL, it is distinguishable from the nasal type of TNKCL in that the former reveals atypical cells having large azurophilic cytoplasmic granules in the peripheral blood and bone marrow. We herein report a rare case of ATNKCL with secondary cutaneous lesions.

A Case of Non-nasal T/NK-cell Lymphoma Occurring in A Patient with Autiphospholipid Syndrome / 대한피부과학회지

Non-nasal T/NK-cell lymphoma(TNKCL) without nasal cavity invasion is a subtype of angiocentric T-cell lymphomas showing the biphenotype of the T-cell and NK-cell. This tumor is characterized by the absence of clonal rearrangement of the T-cell receptor gene, frequent association with Epstein- Barr virus(EBV), poor clinical course, and common extranodal invasion. Antiphospholipid syndrome (APS) is characterized by repetitive spontaneaus abortion, thrombocytopenia, thrombotic symptoms and the positivity to the antiphospholipid antibody. Our patient was a 35-year-old woman with skin lesion on her face. Previously, she had been diagnosed of APS. Histopathological, immunohistochemical and serologic studies could disclose EBV-associated non-nasal TNKCL.