Inhibitory Effect of Topical Nonsteroidal Anti-inflammatory Agents to Prostaglandin before and after Anterior Chamber Paracentesis in Rabbits

It is known that inflammatory processes result from intraocular surgery or ocular trauma mediated by prostaglandin, which cause the protein amounts to increase in anterior chmaber, congestion of vessels, miosis and intraocular pressure to increase. In order to compare the anti-inflammatory effects of antiprostaglandin agents such as Aspegic(R), Profenal(R) and Ocufen(R) in 40 eyes of 20 rabbits, we measured the pupil diameter and amounts of PG E2 and total protein before and after paracentesis. The inhibitory effects of Aspegiz(R), Profenal(R) and Ocufen(R) to pupillary constnztion were significantly greater (p<0.05) than control. The lowering effect to PG E2 and total protein were greater in Aspegic(R), Profenal(R) and Ocufen(R) than control. Through over experiment we suggested that the topical non-steroidal anti-inflammatory agents such as Aspegic(R), Profenal(R), and Ocufen(R) can inhibit the PG activator in antivator chamber and interrupt the miosis and rising intraocular pressure during surgery.

The Effect of Ocufen(R) Eyedrops on Mydriagis during Cataract Surgery

We studied the effect of Ocufen(R), a new ophthalmic nonsteroidal antiinflammatory agent(Flubiprofen), on reducing pupillary constiction during cataract surgery. The study was performed on 63 patients(experimental group:43 patients control group:20 patients). Pupil diameters were meagured at the beginning, after anterior capsulotonly, after lens cortex extraction and after IOL insertion. Pre-operative pupillary diameters were not statisitically different between the control and experimental groups. The change of the pupillary deiameter from the beginning to after IOL insertion averaged 1.0mm in experimental group and 1.9mm in control group. The difference between two groups was statistically significant(P<0.01). The experimental group maintained pupillary dilation better on the average and much smaller incidence of pupil constriction greater than 2mm.

The Effect of Ocufen(R) Eyedrops on Mydriagis during Cataract Surgery

We studied the effect of Ocufen(R), a new ophthalmic nonsteroidal antiinflammatory agent(Flubiprofen), on reducing pupillary constiction during cataract surgery. The study was performed on 63 patients(experimental group:43 patients control group:20 patients). Pupil diameters were meagured at the beginning, after anterior capsulotonly, after lens cortex extraction and after IOL insertion. Pre-operative pupillary diameters were not statisitically different between the control and experimental groups. The change of the pupillary deiameter from the beginning to after IOL insertion averaged 1.0mm in experimental group and 1.9mm in control group. The difference between two groups was statistically significant(P<0.01). The experimental group maintained pupillary dilation better on the average and much smaller incidence of pupil constriction greater than 2mm.