Updates on the relationship between PAPP-A2 and fetus disease / 国际儿科学杂志

Pregnancy-associated plasma protein-A2(PAPP-A2)is a metalloproteinase,which expresses in many tissues and cells,especially in maternal serum and placenta.PAPP-A2 plays an important role in the em-bryonic growth and development. Abnormal PAPP-A2 levels are associated with pre-eclampsia,Down's syn-drome,developmental dysplasia of the hip and other diseases,but the specific mechanism is still unclear.The mo-lecular structure and function of PAPP-A2,the research advances in the relationship between PAPP-A2 and fetus disease are reviewed in this paper.