RESUMEN
Aim To explore the antidepressant mecha-nism and laws of traditional Chinese formula Yueju Pill by taking drug pair as the breakthrough point. Meth-ods On the basis of anti-depressant activities of Yueju Pill, the combination of different herbs was obtained by the successively disassembling, and the key drug pair was obtained through the acute administration of Yueju Pill in mice. In addition, chronic unpredictable mild stress model was established to further verify the anti-depressant effect of key drug pair, and to explore its molecular mechanism. Results The drug pair of zhizi and chuanxiong was necessary to anti-depression effect of Yueju Pill, and the immobility time of TST and FST was significantly reduced. As expected, the expres-sions of IL-6 and TNF-a and p-NF-kBp65, P-IkBa were obviously lower than those in model group, but the expressions of BDNF and TrkB were up-regulated than those in model group. Conclusions The drug pair of zhizi and chuanxiong is necessary for traditional Chinese formula Yueju Pill for the antidepressant effect. It is assumed that the antidepressant effect and mechanism of zhizi and chuanxiong are connected with cytokine IL-6, TNF-a and protein expressions of p-NF-kBp65, P-IkBa, and BDNF.
RESUMEN
Objective To understand the current status of students' self-efficacy and sense of life meaning in medical college students, and explore the relationship between them, then give advice to improve the students' general self-efficacy and the sense of life meaning.Methods A random sampling method was used to select 386 undergraduates in a medical college from freshman to senior.The purpose in life test (PIL) revised by He Jiying (1994) and general self efficacy scale (GSES) revised by Wang Caikang (2001) were used in this research.Data were analyzed by SPSS 18.0 software, and the data were analyzed by t test, x2 test, Spearman correlation analysis.Inspection level of alpha=0.01 (double side).Results The score of GSES was (2.62 ± 0.40), and the score of PIL was (74.06 ± 11.09);t test showed that the PIL score of students with higher GSES score was higher than the PIL score of students with lower GSES score (t=5.054, P=0.000);The correlation analysis showed that GSES score was positively correlated with PIL score (r=0.283, P=0.000).Conclusion The general self-efficacy and sense of life meaning of medical college students are in the medium level, and the positive correlation exists between the two.A series of measures should be adopted to strengthen the students' general efficacy, so as to improve their sense of life.
RESUMEN
Objective]To introduce Professor Lian’s experience of recuperating tumor with Chinese medicine. [Method]To analyze the col ection of Professor Lian’s clinical experience. [Result]Based on pulse and syndrome, using famous descriptions,which is the key of the effectiveness. [Conclusion] Professor Lian is ful of clinical experience, whose descriptions are common and worth studying.
RESUMEN
[Objective] To observe the cure effect of Qianlishu Pil combined with hydrochloric acid doxycycline and Hytrine on chronic nonbacterial prostatitis(CNP). [Method] Select 264 cases of CNP, randomly divide them into control and treatment groups, n=132 for each. The control group was treated with hydrochloric acid doxycycline and Hytrine for 2m; the treatment group, with combined Qianlieshu Pil with hydrochloric acid doxycycline and Hytrine for 2m;make analysis and comparison of 2 groups after treatment. [Result] The effect and clinical signs recovery time were better in treatment group than control one; the total effective rate was 88.9% for treatment group, and 53.8% for control one, the comparison of them had difference of statistical meaning. [Conclusion] The combination of Qianlieshu Pil , hydrochloric acid doxycycline and Hytrine has marked cure effect on CNP.
RESUMEN
[Objective] To sum up the clinical efficiency of Qianyang Fengsui Pil (suppress Yang and seal marrow)Pil (hereafter cal ed Pil ). [Method] By introducing medicine composition, functions and indications, it enumerates 3 cases to analyze the clinical application of the Pil . [Result] The Pil is the mostly recommended by vulcans, with function of inducing Qi to kidney and fire to the root.[Conclusion] The Pil has good clinical cure effect on the diseases of fire not returning to the origin and deficient Yang come-up, worth wide application.
RESUMEN
[Objective] Preliminary clinical experience of Wang Zuoshun using Da Chaihu decoction contacts with other decoctions in the treatment of re-fractory hypertension in winter. [Methods] From the etiology and pathogenesis, syndrome differentiation and treatment, clinical treatment experience sum-mary of Professor Wang Zuoshun 's treatment of winter refractory hypertension academic ideas and clinical experience, also from the classical articles, the-ory of constitution etc to expound the omechanisationf the clinical experience.[Results] The etiology is phlegm, blood stasis, induced by cold pathogen, its pathogenesis are dysfunction of Shaoyang, accumulation of phlegm-heat and blood stasis, cold accumulation, according to the etiology and pathogenesis, forming a cardinal in Shaoyang, purging heat, resolving phlegm and removing blood stasis, slightly with temperature and the treatment. [Conclusions] In clinical work, Wang Zuoshun director using syndrome differentiation and treatment, researches the pathogenesis, flexibility in the use of traditional Chinese herbal soup recipe in treating winter refractory hypertension, the curative effect is remarkable, and has popularization and application value.
RESUMEN
[Objective] Discussion about feeding Liuwei dihuang pil to different ages of mental retardation intel igence-type mice, then test their intel igence level and mechanism. [Methods]The changes of ethology expressions are determined in healthy KunMing mice of five groups divided randomly:male mice (n=5), female mice(n=20). Group A:normal control group;Group B:the group with innate kidney deficiency and lead ingested. Group C:the group of lead poisoning, and the offspring mice are administered pil s. Group D:the group with innate kidney deficiency and lead ingested, and the adult mice are adminis-tered pil s. Group E:the group with innate kidney deficiency and lead ingested, and both the adult mice and offspring mice are administered pil s. According to the proportion of male and female mice, make them mate, remove the male mice. Before delivery, do threat means and give 0.1%Lead acetate trihydrate solution to Groups B,C,D,E.Groups D,E have tonifying the kidney. Give routine food to Groups A,B,C. Female mice wil labor in 19~22 days after mating, getting the offspring mice. The offspring mice in different periods of growth are carried out ethology determination and analyzed.[Results]Newborn rat kid-ney stand test shows rat offspring is not better than the success rate of kidney emancipated group, juvenile rat kidney tests show space group behavior test per-formance superior to that of kidney group, and long-term kidney group(offspring, mother on behalf of both rat kidney) or female offspring than only on be-half of kidney groups, multiple comparisons between groups(LSD-t statistical analysis) are statistical y significant, A group compared with B group, C group, D groups respectively(t=27.50,8.10,9.30,3.00,P<0.05), B group compared with C group, D group, E group(t=19.40,18.20,27.80, P al <0.05), C group and D group have difference statistical y significant(t=8.40, P<0.05), D group and E group difference is statistical y significant(t=9.60, P<0.05), young rats tightrope test, kidney group to some extent, is stil better than not Bushen group, multiple comparisons between groups find that:A group and D group, B group and C group, B group and E group, C group and D group, D group and E group have differences statistical y significant(t=22.01, 25.41,20.90,32.11,27.60, P<0.05). [Conclusion]Liuwei Dihuang Pil can improve the intel igence level of mice to a certain extent.
RESUMEN
Eisosomes, large protein complexes that are predominantly composed of BAR-domain-containing proteins Pil1 and its homologs, are situated under the plasma membrane of ascomycetes. A successful targeting of Pil1 onto the future site of eisosome accompanies maturation of eisosome. During or after recruitment, Pil1 undergoes self-assembly into filaments that can serve as scaffolds to induce membrane furrows or invaginations. Although a consequence of the invagination is likely to redistribute particular proteins and lipids to a different location, the precise physiological role of membrane invagination and eisosome assembly awaits further investigation. The present review summarizes recent research findings within the field regarding the detailed structural and functional significance of Pil1 on eisosome organization.
RESUMEN
Se analizan las diferencias en las puntuaciones total y factoriales de la versión española del Purpose-In-Life Test [PIL] (Crumbaugh & Maholic, 1969; Noblejas de la Flor, 1994) asociadas al sexo, en un grupo de 309 estudiantes universitarios (207 mujeres y 102 hombres) de edades comprendidas entre 18 y 45 años. El PIL evalúa logro de sentido de la vida vs. vacío existencial. Las mujeres obtienen puntuaciones medias superiores a los hombres, tanto en la puntuación total del PIL como en sus diferentes factores. El análisis estadístico muestra que el sexo da lugar a diferencias estadísticamente significativas en la puntuación total y en los factores Percepción de sentido y Metas y tareas del PIL.
The aim of this paper is to analyze the differences on Purpose-In-Life Test [PIL] (Crumbaugh & Maholic, 1969) total and factorial scores associated to sex, among 309 spanish undergratudates (207 women, 102 men), range 18 to 45 years. PIL Spanish version is used (Noblejas de la Flor, 1994). PIL evalues life meaning achievement vs. existential vacuum. Women achieve higher means on PIL total and factorial scores, and estatistical analysis show that sex is significantly associated to total PIL score and on Purpose perception and Goals and tasks factors scores.
RESUMEN
Eisosomes are large immobile assemblies at the cortex of a cell under the membrane compartment of Can1 (MCC) in yeast. Slm1 has recently been identified as an MCC component that acts downstream of Mss4 in a pathway that regulates actin cytoskeleton organization in response to stress. In this study, we showed that inactivation of Slm proteins disrupts proper localization of the primary eisosome marker Pil1, providing evidence that Slm proteins play a role in eisosome organization. Furthermore, we found that slmts mutant cells exhibit actin defects in both the ability to polarize cortical F-actin and the formation of cytoplasmic actin cables even at the permissive temperature (30°C). We further demonstrated that the actin defect accounts for the slow traffic of FM4-64-labelled endosome in the cytoplasm, supporting the notion that intact actin is essential for endosome trafficking. However, our real-time microscopic analysis of Abp1-RFP revealed that the actin defect in slmts cells was not accompanied by a noticeable defect in actin patch internalization during receptor-mediated endocytosis. In addition, we found that slmts cells displayed impaired membrane recycling and that recycling occurred in an actin-independent manner. Our data provide evidence for the requirement of Slm proteins in eisosome organization and endosome trafficking and recycling.
RESUMEN
The first hospital to practice western medicine in Korea, Chejungwon, was opened on April 10, 1885. Then on March 29, 1886, Chejungwon Medical School, Korea's first school to teach western medicine, opened. While anatomy was taught at that time by missionary doctors, there was no Korean translation of an Anatomy textbook. Therefore, Dr. O.R. Avison, who reopened and took charge of Chejungwon Medical School on November 1, 1893, began translating the popular "Gray's Anatomy" with the aid of Korean assistants. Although the text was translated twice, it was not published due one of the manuscripts having gone missing and the other having been lost in a fire. It wasn't until 1906 when the first "Textbook of Anatomy" was translated and published in 3 volumes by Dr. Avison and Mr. Pil Soon Kim (the first graduate of Chejungwon Medical School in 1908). This translation was not based on Gray's Anatomy, but rather on Imada Tsukane's "Practical Anatomy", which had been written in Japanese. During a previous translation, Dr. Avison and Mr. Kim referred to many Chinese and Japanese textbooks, especially for choosing the proper medical terms expressed in Chinese characters. With a basic understanding of how medical terms were expressed in Chinese characters, they decided to translate Imada's textbook. The translation was completed within several months. When comparing the translated textbook with Imada's original one, several pictures were deleted or replaced with others by the translators. Also, much of the narrative was reinforced in detail and new subtitles were used throughout the text. By modifying its contents, they evidently wanted to make this new translation more complete than Imada's original. The text was republished in 1909, but could not be maintained or updated in successive editions due to the Japanese annexation of Korea in 1910.
Asunto(s)
Humanos , Pueblo Asiatico , Incendios , Corea (Geográfico) , Misiones Religiosas , Facultades de Medicina , TraducciónRESUMEN
Objective: To research the usability of the purpose-in-life test (PIL) for Chinese university students and evaluate the test’s reliability and validity. Methods: 1171 University students were measured by PIL, SCL-90 and Index of Well-being, and 140 University students were retested by PIL. Results: PIL had four factors (life feeling, life goal, life attitude and self-control) which were extracted by factor analysis. The split half reliability was 0.786, the Cronbach ?-co-efficient of PIL and the four factors were 0.878, 0.860, 0.809, 0.270, 0.406 respectively. The test-retest reliability were 0.837,0.849,0.630,0.314,0.728. The scores of Index of Well-being, the total scores of SCL-90 and the factor of depression were used as external criterion;the criterion correlation coefficient were 0.769,-0.504,-0.560 respectively. The correlations between the criterion and the four factors were significant (r=-0.240～0.787, P
RESUMEN
Kwang Hye Won(Je Joong Won), the first western hospital in Korea, was founded in 1885. The first Medical School in Korea was open in 1886 under the hospital management. Dr. O. R. Avison, who came to Korea in 1893, resumed the medical education there, which was interrupted for some time before his arrival in Korea. He inaugurated translating and publishing medical textbooks with the help of Kim Pil Soon who later became one of the first seven graduates in Severance Hospital Medical school. The first medical textbook translated into Korean was Henry Gray's {Anatomy}. However, this twice-translated manuscripts were never to be published on account of being lost and burnt down. The existing early anatomy textbooks, the editions of 1906 and 1909, are not the translation of Gray's {Anatomy}, but that of Japanese anatomy textbook of Gonda. The remaining oldest medical textbook in Korean is {Inorganic Materia Medica} published in 1905. This book is unique among its kinds that O. R. Avison is the only translator of the book and it contains the prefaces of O. R. Avison and Kim Pil Soon. The publication of medical textbook was animated by the participation of other medical students, such as Hong Suk Hoo and Hong Jong Eun. The list of medical textbooks published includes almost all the field of medicine. The medical textbooks in actual existence are as follows. {Inorganic Materia Medica (1905)}, {Inorganic Chemistry(1906)}, {Anatomy I(1906)}, {Physiology(1906)}, {Diagnostics I(1906)}, {Diagnostics II(1907)}, {Obstetrics(1908)}, {Organic Chemistry (1909)}, {Anatomy(1909)}, {Surgery(1910)}.
Asunto(s)
Resumen en Inglés , Corea (Geográfico) , Facultades de Medicina/historia , Libro de Texto/historia , Traducciones , Mundo OccidentalRESUMEN
Kim Pil Soon was born at Sorae Village of Hwang Hye Province, the birth place of the Protestantism in Korean. He was brought up under the strong influence of Christianity and received modern education at Pae Chae School according to the ecommendation of Rev. Underwood. In 1899, Kim Pil Soon, who had been working at Je Joong Won as an assistant and nterpreter of Dr. Sharrocks, was employed by Dr. Avison to help preparing medical textbooks and asked to participate in the medical education. He acquired medical knowledges through his work of translating various medical texts, and which enabled him to teach other medical students. He participated in the administration of the Hospital, taking charge of the provision of meals for in-patients as well as directing the construction of Severance Hospital buildings. And his experience of treating soldiers wounded during the turmoil of the forced dismission of the Korean Army by the Japanese lead him to reflect seriously on Korea's fate in peril. In addition, he became a member of Sinmin Society, a secret political association, to engage in the independence movement. In 1908, Kim Pil Soon graduated from Severance Hospital Medical School as one of the first seven graduates. On graduation, he was appointed as a professor and took the charge of school affaires in 1910. At first, he worked as a assistant physician of ward and surgery, then he took the responsibility of out-patient clinic in 1911. But suddenly, in December 1911, he exiled to China to escape from the Japanese police who was in pursuit of him on account of his involvement in the so-called 105-Person Affaire, a fabricated affaire served as a pretext for the persecution of independence movement. He continued the independence movement in the form of an ideal village movement and training the Independence Army. In 1919, however, he was poisoned to death in a mysterious way. Kim Pil Soon dedicated himself to the independence movement that demands personal sacrifice: giving up his prospective career as a doctor, professor, and hospital administrator. He no longer remained as a ordinary clinician who treats only diseased persons, but transformed himself to the Great Doctor, a time-old ideal type of doctor in the East Asian countries who treats and cures the diseased nation, by dedicating himself to the independence movement.
Asunto(s)
Educación Médica/historia , Resumen en Inglés , Libertad , Corea (Geográfico) , Misiones Religiosas/historia , Política , Retrato , Edición/historia , Libro de Texto/historiaRESUMEN
Objective: To establish the method of determination of the content of Berberine hydrochloride and Palmatine hydrochloride in Wuji Pills. Methods: Ultrasonic extraction, HPLC was used to determine Berberine hydrochloride and Palmatine hydrochloride in Wuji Pills on C 18 Column, using 0.033mol/L KH 2PO 4 CH 3CN(90∶40) as mobile phase, with detection at 265nm. Results: The linearity of this method was well. The average recoveries were 99.07% for Berberine hydrochloride and 98.59% for Palmatine hydrochloride. RSD were 1.3% and 1.7%, respectively. Conclusion: This method shows good separating degree and can be used for quality control of Wuji Pills.
RESUMEN
Objective:To investigate the effects of pIL-12 plasmid DNA on apoptosis of splenocytes in mice infected with protoscoleces of hydatid cyst of E.granulosus(Eg).Methods:BALB/c mice were intramuscularly vaccinated by pIL-12 plasmid DNA,then challenged with Eg protoscoleces on 8 w of vaccination and killed on 18W of infection to count rate of reduced hydatid cyst weight.The spleen was gathered to separate splenocytes,splenocytes then were cultured by stimulation with ConA,and apoptotic rate of splenocytes were measured by FACsort.BCG and PBS were served as control.Results:In the group of pIL-12 plasmid DNA immunization,the rate of reduced hydatid cyst weight was 44.85%;apoptotic rate of splenocytes in the pIL-12 plasmid DNA group was lower than that in the PBS control.Conclu-sion:pIL-12 plasmid DNA may inhibit apoptosis of splenocytes in mice infected with hydatid cyst of Echinococcus granulosus.