Expression and Clinical Relations of PTPRD in Esophageal Squamous Cell Carcinoma / 现代检验医学杂志

Objective To identify the expression of PTPRD in esophageal squamous cell carcinoma (ESCC)and analyze its correlation with pathological features and patient survival.Methods Immunohistochemistry analysis was applied to detect the expression level and location of PTPRD in 236 patients with ESCC.Clinical and pathological features were collected and a 5 years’follow-up after surgery were performed.Results Statistic analysis showed that expression of PTPRD in ESCC was lower than in normal esophageal epithelial cells (22.0% vs 57.2%,P =0.000).The expression of PTPRD was correla-ted to the differentiation grade,depth of tumor invasion and lymph nodes metastasis.The expression of PTPRD was higher in group with well differentiation,less invasion depth and no lymph node metastasis (P =0.013,0.025,0.019).The expres-sion of PTPRD was not correlated to age or gender (P =0.170,0.787).The survival analysis showed that thegroup with more PTPRD expression had better prognosis.Conclusion PTPRD was correlated to progression and prognosis of ESCC.It may be a new potential tumor suppressor gene of ESCC,and its expression level might may a useful marker for predicting prognosis for ESCC patients.

The PTPRD (Protein Tyrosine Phosphatase Receptor Type Delta) Gene Polymorphism and Antipsychotic-Induced Restless Legs Syndrome in Schizophrenia / 대한정신분열병학회지

OBJECTIVES: The previous genome-wide association studies have revealed several candidate genes for restless legs syndrome (RLS). The PTPRD (protein tyrosine phosphatase receptor type delta) gene is one of the candidate genes for RLS. The occurrence of antipsychotic-related RLS could also be attributable to differences in genetic susceptibility. This study aimed to investigate whether PTPRD polymorphism is associated with antipsychotic-related RLS in schizophrenia. METHODS: We assessed symptoms of antipsychotic-induced RLS in 190 Korean schizophrenic patients and divided the subjects into two groups according to the International Restless Legs Syndrome Study Group diagnostic criteria : (i) subjects that met all of the criteria (n=44) and (ii) the remaining subjects who were not considered to be RLS patients (n=146). PTPRD rs462664 was genotyped by PCR in 190 individuals. The chi2-test was performed to compare differences between two groups. RESULTS: The frequencies of genotype (chi2=1.31, p=0.519) of the PTPRD rs462664 did not differ significantly between schizophrenic patients with and without RLS. The difference of allele frequencies (chi2=1.30, p=0.25) of the PTPRD rs462664 between the schizophrenic patients with and without RLS were not significant. CONCLUSION: These results suggest that PTPRD gene polymorphism does not play a major role in susceptibility to antipsychotic-related RLS in schizophrenia. This finding suggests that antipsychotic-induced RLS may have a different pathogenesis compared to primary RLS.

Effect of PTPRD rs2279776 gene and interaction with hepatitis B virus mutations on the risk of hepatocellular carcinoma / 中华流行病学杂志

Objective To investigate the effect of rs2279776 at the PTPRD and its interactions on hepatitis B virus (HBV) mutations as well as related risk on hepatocellular carcinoma (HCC).Methods A total of 3023 individuals,including t012 healthy controls,990 HCC-free HBV-infected subjects,and 1021 HBV-caused hepatocellular carcinoma patients (HCC) were involved in this study.PTPRD rs2279776 was genotyped,using quantitative PCR.HBV enhancer Ⅱ/basal core promoter/precore (Enh Ⅱ/BCP/preC) and preS regions were amplified by nested PCR and directly sequenced.Logistic regression analysis was performed to test the association among rs2279776 polymorphism,HBV mutations,and their interactions on the risk of HCC.Results The distributions of rs2279776 genotypes and allelic frequencies between HCC patients and healthy controls,HCC patients and HBsAg-positive subjects without HCC,HCC patients and HCC-free population (HBsAgpositive subjects without HCC and healthy controls) showed no statistically significant differences.However,the interactions of GC genotype on HBV mutations T1753V and preS deletion significantly increased on the risk of HCC in female HBV-infected subjects.Same result was also seen for rs2279776 C allele (GC + CC).The interaction of rs2279776 GC genotype with G1896A could reduce the risk of HCC in HBV genotype B infected subjects and the interaction of CC genotype with A1652G significantly reduced the risk of HCC in HBV genotype C infected subjects.Conclusion PTPRD rs2279776 did not directly contribute to the genetic susceptibility on HCC risk.However,it might affect the risk of HCC via interacting with HBV mutations.