Single-center, retrospective study on changes in pain-relieving therapy after bone metastasis detection by bone scintigraphy in prostate cancer patients

Abstract Whole-body bone scintigraphy (WB-BS) is used for detecting and monitoring metastatic spread of prostate cancer (PCa) and to investigate bone pain episodes. To investigate the impact of a positive WB-BS on pain-relieving medicine prescription in PCa patients, a single-center, retrospective cohort study with PCa patients classified as positive for bone metastases (BM) by WB-BS was conducted. Demographic, clinical, and ambulatory pain-relieving medicine prescription data were evaluated. Pain-relieving medicines were categorized according to the WHO 'Analgesic Ladder'. Regimens adopted before and after WB-BS were compared. Differences were considered significant at p<0.05. A total of 180 PCa patients were diagnosed with BM, 64.4% of whom were ≥65 years of age. Thirty-three patients were prescribed analgesics only after WB-BS, mostly including NSAIDs and weak opioids. Pain-relieving prescription changed after WB-BS in patients with prescriptions before and after WB-BS, with a reduction in NSAIDs and adjuvants and an increase in weak and strong opioids. In addition, 40% of patients with WHO analgesic step 1 drugs and 21.7% of patients with WHO step 2 drugs before WB-BS changed to other WHO steps after WB-BS. Pain-relieving prescriptions changed after a positive WB-BS, providing evidence that it could contribute to clinical management of painful metastatic PCa patients.

Systematic review on clinical efficacy and safety of Cheezheng Pain Relieving Plaster for soft tissue injury / 中国中药杂志

To systematically evaluate the clinical efficacy and safety of Cheezheng Pain Relieving Plaster in the treatment of soft tissue injury. Four Chinese databases(namely CNKI, WanFang, VIP, CBM) and 2 English databases(namely PubMed, Cochrane Library) were retrieved from the establishment of each database to March 2019. The randomized controlled trials of Cheezheng Pain Relieving Plaster compared with routine therapy in treatment of soft tissue injury were included. The quality of the included studies was assessed using the Cochrane Risk Assessment Tool. Five studies were included, and 367 patients were enrolled. None of the included studies reported randomized concealment, blinding, follow-up and dropping off. The results showed that Cheezheng Pain Relieving Plaster may have advantages in alleviating joint pain, swelling, tenderness and dysfunction and other symptoms, with no serious adverse reaction. Compared with routine therapy, Cheezheng Pain Relieving Plaster may have advantages in the treatment of soft tissue injury. However, due to the quality of the included RCTs, the conclusions of this study were limited. In addition, to produce high-quality evidences for the clinical application of Cheezheng Pain Relieving Plaster, the conclusions of this study shall be further verified with large-sample, scientifically designed and strictly implemented clinical trials.

Clinical trials of acupuncture treatment of post-stroke shoulder pain / 针刺研究

OBJECTIVE: To observe the clinical therapeutic effect of "Tiaoshen Zhitong" (mental regulating and pain relieving) needling and its influence on serological indicators in the treatment of post-stroke shoulder pain, so as to provide new therapeutic thoughts and approach for post-stroke shoulder pain. METHODS: A total of 80 inpatients with post-stroke shoulder pain were randomly divided into a control group (routine needling, 39 cases) and an observation group ("Tiaoshen Zhitong" needling, 41 cases) according to the random number table. Patients of the two groups accepted basic medication treatment including anticoagulants, hypotensive drugs, hypoglycermic drugs, lipid-lowering drugs, etc. In addition, patients of the control group were also treated by routine acupuncture stimulation (uniform reinforcing-reducing stimulation) of Jianyu (LI15), Jianqian (EX-UE12), Jianhou (Extra), Jianliao (TE14), Waiguan (TE5) and Hegu (LI4) on the affected side, and those of the observation group also treated by "Tiaoshen Zhitong" needling of Ear-Shenmen (MA-TF1), bilateral Neiguan (PC6, lifting-thrusting-reducing method), Shuigou (GV26, lifting-thrusting-reducing method), and Jianyu (LI15), Jianliao(TE14), Jianzhen (SI9) and Yanglingquan (GB34, the latter 4 points were stimulated with uniform reinforcing-reducing method) on the affected side. The treatment was given once every day, 6 days a week for 4 weeks. The pain severity was assessed by using visual analogue scale (VAS), the upper limb function evaluated by using Fugl-Meyer assessment (FMA) scale, the shoulder-joint function evaluated by using Constant-Murley score (CMS) questionnaire, and the daily living ability assessed by using Barthel index (BI) scale. The enzyme linked immunosorbent assay (ELISA) was used to determine the contents of serum beta-endorphin (β-EP), enkephalin (ENK) and dynorphin (Dyn). The clinical therapeutic effect was evaluated by using Nimodipine scale method. RESULTS: Of the 39 and 41 cases in the control and observation groups, 7(17.95%) and 12(29.27%) were basically cured, 12(30.77%) and 13(31.71%) experienced marked improvement, 8(20.51%) and 11(26.83%) were effective, 12(30.77%) and 5 (12.19%) failed, with the total effective rate being 69.23% and 87.80%, respectively. The effective rate of the observation group was significantly higher than that of the control group (P<0.05). After the treatment, the VAS score was obviously reduced (P<0.01), and the scores of FMA scale, CMS questionnaire and BI scale, and contents of serum β-EP, ENK and Dyn were all increased obviously in the two groups compared with their own pre-treatment (P<0.01). The therapeutic effect of "Tiaoshen Zhitong" needling was significantly superior to that of the routine needling in lowering VAS, and in raising scores of FMA scale, CMS questionnaire and BI scale and in up-regulating serum β-EP, ENK and Dyn levels (P<0.01). CONCLUSION: "Tiaoshen Zhitong" needling is effective in reducing post-stroke shoulder pain and improving the motor function of the upper limb and shoulder-joint as well as the quality of daily life in stroke patients with shoulder pain. Its analgesic effect is probably related to the increase of the levels of serum β-EP, ENK and Dyn.

Osteotomía del peroné, nueva técnica quirúrgica en el genu varo doloroso. Proceder y presentación de dos casos / Fibular osteotomy, new surgical technique in the painful genu varum: procedure and two-case presentation

La artrosis de rodilla puede llegar a ser una patología muy invalidante por los síntomas que produce, caracterizados por dolor, inseguridad y pérdida funcional. Es una patología degenerativa cuya prevalencia ha ido en aumento en las últimas décadas. Está muy ligada al aumento de las expectativas de vida de la población, fenómeno que ocurre en países del primer mundo con un alto nivel de salud y que ocurre igualmente en nuestro país dado el desarrollo de nuestro sistema de salud. Existen múltiples técnicas quirúrgicas para corregir la deformidad y aliviar el dolor; van desde osteotomías correctoras hasta las artroplastias, todas encaminadas al alivio del dolor en primer lugar y a corregir las deformidades, pero las últimas conllevan mayor tiempo de rehabilitación y son más costosas. Este trabajo va encaminado a la presentación de dos pacientes operados con la nueva técnica del Dr. Ying Ze Zhang, del Departamento de Cirugía Ortopédica del Tercer Hospital de la Universidad Médica de Hebei en Shijiazhuang, China, con la cual, a través de una osteotomía, se descomprime el compartimento interno y se quita tensión ósea en el externo por la resección peronea. Sus objetivos son actuar sobre el dolor, mejorar la función y la marcha como beneficios de este proceder de mínima acción sobre las partes articulares y lograr la rápida incorporación del paciente a su vida social; esto es tema para la obtención del doctorado por parte del autor principal del presente trabajo (AU).

Knee osteoarthritis could be a very disabling disease due to the symptoms it produces, characterized by pain, insecurity and functional loss. It is a degenerative disease which prevalence has increased in the last decades tightly related to the increment of the population's life expectancy, phenomenon occurring in the developed countries with a high life level and also occurring in our country because of the development of our health system. There are several surgical techniques to correct deformation and to relieve pain. They go through correcting osteotomies to arthroplasties, all of them aimed, firstly to pain relieving and also to correcting deformations. The last ones need more rehabilitation time and are more expensive. This work is devoted to presenting two patients operated with the new technique of Dr. Yin-Ze Zhang, from the Department of Orthopedic Surgery of the Third Hospital of the Medical University of Hebei, in Shijiazhuang, China, with which, through an osteotomy, the internal compartment is decompressed and the bone tension in the external one is finished due to the peroneal excision. Its aims are acting upon the pain, improving function and gait as a benefit of this minimal action procedure on the articular parts and achieving the faster incorporation of the patient to his social life; this is the theme the main author of this article is going to develop for obtaining the doctorate in sciences (AU).

Short term effects of 1g/L bromfenac sodium eye drops after LASEK / 国际眼科杂志(Guoji Yanke Zazhi)

?AIM: To compare postoperative anti -inflammation effect and safety between bromfenac sodium eye drops and pranoprofen eye drops in patients after laser epithelial keratomileusis ( LASEK) .? METHODS: In the prospective, randomized and controlled study, 100 patients ( 200 eyes ) undergoing LASEK were randomized into the bromfenac sodium group (100 eyes) and control group (100 eyes).Patients in bromfenac sodium group received bromfenac sodium hydrate ophthalmic solution eye drops twice a day in 3d before surgery and 2wk after surgery, while the patients from the control group were given proanoprofen eye drops 4 times a day in the same period.At 1, 3, 5d, 1 and 3mo after surgery, irritative symptoms grade, duration of irritation, time for corneal epithelial healing, cornel haze, uncorrected visual acuity and intraocular pressure ( IOP ) were observed and compared between the two groups. Quantitative data were analyzed using independent samples t-test and ranked data were statistically analyzed using the Mann-Whiteney rank sun test.?RESULTS:There was no significant difference between two groups in irritative symptoms grade ( P =0.317 ), neither was existed between two groups in uncorrected visual acuity after surgery (P>0.05).There was no statistical significance in the time for corneal epithelial healing between two groups (P=0.551).?CONCLUSION: Bromfenac sodium eye drops ( 1g/L ) can achieve the same therapeutic effect as pranoprofen eye drops after LASEK.

Problemas actuales del tratamiento del dolor posoperatorio / Current problems in the treatment of posoperative pain

Introducción: el dolor agudo perioperatorio no debiera ser un problema, pues se dispone de los conocimientos, fármacos, tecnología e infraestructura necesarios para su correcto tratamiento. Además, se conoce la causa, su finitud y su respuesta favorable a los analgésicos adecuados. Objetivo: identificar algunos problemas actuales que inciden en el tratamiento del dolor posoperatorio. Métodos: se realizó un estudio retrospectivo tomando la información de las historias clínicas de 138 pacientes operados por afecciones del hemiabdomen superior y del tórax, en el período de un año en el Hospital Clinicoquirúrgico "Hermanos Ameijeiras". Se recogió y analizó la frecuencia con que se realizaron indicaciones consideradas no óptimas en el tratamiento ante el dolor, la aparición de complicaciones postoperatorias y, su relación con este. Resultados: los analgésicos prescritos con mayor frecuencia fueron los antinflamatorios no esteroideos (AINEs). Los de mejor asimilación en el alivio, del dolor fueron los anestésicos locales y los opioides. Existe una relación significativa entre las indicaciones no adecuadas y la alta frecuencia de persistencia del dolor en el postoperatorio. De igual modo ocurre con la presentación de complicaciones y el ingreso en la Unidad de Cuidados Intensivos (UCI). Cuando se realizan indicaciones no óptimas para el dolor, la frecuencia de complicaciones posoperatorias se eleva en más de 15 %. Conclusiones: la incidencia de dolor en el posoperatorio supera 50 %, e incide en la morbilidad posoperatoria en 15 %. Las indicaciones no óptimas más frecuentes fueron, el no monitoreo de la escala de dolor y la analgesia a demanda. Esto influyó en el aumento de la frecuencia de aparición del dolor, en la morbilidad y en la admisión en la UCI.

Introduction: there is no reason for acute perioperative pain to be a problem, for the knowledge, drugs, technology and infrastructure required for its effective treatment are all available. On the other hand, its causes, finiteness and favorable response to adequate analgesics are well known. Objective: identify some current problems affecting the treatment of postoperative pain. Methods: a retrospective study was conducted based on information from the medical records of 138 patients undergoing upper abdominal and thoracic surgery at Hermanos Ameijeiras Clinical Surgical Hospital in a period of one year. Data on the frequency of non-optimal pain relieving indications were collected and analyzed, as well as data on the appearance of postoperative complications and their relationship to pain. Results: non-steroidal anti-inflammatory drugs (NSAIDs) were the analgesics most commonly prescribed. Local anesthetics and opioids were the most effective pain relievers. A significant relationship was found between inadequate indications and the high frequency of pain persistence in the postoperative period. The same is true of the appearance of complications and the admission to the Intensive Care Unit (ICU). When non-optimal pain relieving indications are made, the frequency of postoperative complications rises by more than 15 %. Conclusions: the incidence of postoperative pain exceeds 50 % and affects postoperative morbidity in 15 %. Not monitoring the pain scale and on-demand analgesia were the most common non-optimal indications. This had an effect on the frequency in the appearance of pain, on morbidity and on admission to the ICU.

Pulsed Radiofrequency Treatment of Pain Relieving Point in a Soft Tissue

Pulsed radiofrequency (PRF) treatment of nervous tissue has been proposed as a less neurodestructive technique alternative to continuous RF heat lesioning. Recently, clinical reports using PRF have shown favorable effects in the treatment of a variety of focal pain areas, even in non-nervous tissues; however, the mechanism of effect underlying this treatment to non-nervous tissue remains unclear. We report the case of a 67-year-old male who presented with pain reliving point in the posterior neck. The patient had pain in the posterior neck for 3 years. The pain subsided with pressure applied to a point in the posterior neck. There were no specific abnormal findings on laboratory testing and radiologic examinations. After PRF treatment to the pain-relieving point, he had pain relief which lasted more than 5 months.

Pulsed Radiofrequency Treatment of Pain Relieving Point in a Soft Tissue

Pulsed radiofrequency (PRF) treatment of nervous tissue has been proposed as a less neurodestructive technique alternative to continuous RF heat lesioning. Recently, clinical reports using PRF have shown favorable effects in the treatment of a variety of focal pain areas, even in non-nervous tissues; however, the mechanism of effect underlying this treatment to non-nervous tissue remains unclear. We report the case of a 67-year-old male who presented with pain reliving point in the posterior neck. The patient had pain in the posterior neck for 3 years. The pain subsided with pressure applied to a point in the posterior neck. There were no specific abnormal findings on laboratory testing and radiologic examinations. After PRF treatment to the pain-relieving point, he had pain relief which lasted more than 5 months.

Clinical Observation of Rectal Administration of Morphine Sulfate Controlled-release Tablets for Terminal Cancerous Pain / 中国药房

0.05),but the rectal administration showed a quicker response in pain-relieving than the oral administration of Morphine Sulfate Controlled-release tablets(P

Optimization of Formula of Compound Xylocaine Cream / 中国药房

OBJECTIVE:To optimize the formula of compound xylocaine cream.METHODS:Orthogonal design was employed to optimize the amount of each component in the formula of compound xylocaine cream,and the pain threshold improvement rate in pain-relieving experiment of mice and the mice ear edema inhibition rate in the anti-inflammatory experiment served as indexes to optimize the formula,meanwhile a verification test was conducted.RESULTS:The optimized formula was as follows:xylocaine 20 g,chlorphenamine maleate 5 g,menthol 20 g,mupirocin 20 g in every 1 000 g cream.Both the pain threshold improvement rate and the ear edema inhibition rate in mice were all higher than 60%,which were up to the standard.CONCLUSION:The formula for compound xylocaine cream is reasonable,and this study provids experimental basis for clinical application of compound xylocaine cream.

Pain Relieving Effect of Intraoral Sucrose Replacement in Neonates / 아동간호학회지

The ability of neonates to perceive and react to pain, has been acknowledged recently. Recent researches have been shown that even short term pain can have lasting negative effects. We know that most of the anatomical pathway and neurotransmitter function necessary for pain perception are fully or nearly fully developed in the neonatal period. Many people are still reluctant to believe that pain felt by neonates may be as severe as that felt by older children or adults yet. The objective of the study is to assess and compare the analgesic effects of orally administered sucrose and pacifiers. And to determine the synergistic analgesic effects of sucrose and pacifiers. The tools for this study is Lawrence's NIPS (neonatal infant pain scale) with behavioural pain responses and index for pain physiological reponses as heart rate, respiratory rate and degree of SaO2. The participants are 96 healthy infants of neonatal age 1-7days and randomised to receive heel prick before 2minutes to blood sampling and physiological test in Nursery of K Medical University Hospital on May-July, 2000. The experimental group assigned to one of three treatment groups : no treatment; a pacifier; placebo(2ml 25% sucrose). Collected data were analyzed with the SAS program using X2-test, ANOVA and Duncan's multiple range test as post hoc. The results were as follows. 1) Pain behaviour responses: The pain score of placebo group(2ml 25% sucrose) is lower than no treatment group and pacifier group significantly(P=.000). Placebo group is different from no treatment and pacifier group with Duncan's multiple range test. 2) Pain physiologic responses (1) heart rate: The heart rate of placebo group(2ml 25% sucrose) is different from that of no treatment group and pacifier group significantly(P=.000). The heart rate change of placebo group is less than the other groups. (2) respiratory rate: The respiratory rate of placebo group(2ml 25% sucrose) is different from that of no treatment group and pacifier group insignificantly (P=.2340). But, the respiratory rate of placebo group is lower than the other groups. (3) SaO2: The SaO2 score of placebo group(2ml 25% sucrose) is different from that of no treatment group and pacifier group insignificantly (P=.3265). But, the change of SaO2 score of placebo group is less than the other groups. In conclusion, the sucrose placebo showed pain relief effect in behavior responses and less physiological responses. Accordingly, the sucrose placebo should be applied nursing intervention for simple pain management as heel prick.