Papuloerythroderma of Ofuji

Papuloerythroderma of Ofuji is a rare type of erythroderma of the elderly and consists of flat-topped erythematous papules that coalesce, forming diffuse sheets that characteristically spare skin folds (so called 'deck-chair' sign). The etiopathogenesis of the disease remains unknown, but a number of cases have demonstrated the connection of this disorder with malignancy, mainly cutaneous T cell lymphoma. We report a case of papuloerythroderma of Ofuji unassociated with underlying malignancy, with the biopsy specimen showing nonspecific eczematous findings. There are cases of papuloerythroderma of Ofuji associated with malignancy, and one needs to be mindful of such in examinations.

A Case of Papuloerythroderma of Ofuji Improved by Cyclosporine and Topical Tacrolimus / 대한피부과학회지

Papuloerythroderma of Ofuji isa rare and unique form of erythroderma and usually affects elderly Asian men. Various therapeutic approaches have been tried and both systemic corticosteroids and PUVA have been reported to be most effective. A 57-year-old man presented with itchy erythematous papules forming erythroderma that did not affect skin folds. His lesion did not respond to topical corticosteroids and antihistamines for 2 weeks. We used cyclosporine and topical tacrolimus. He completely recovered several days later and there has been no sign of recurrence for nearly 1 year.

A Case of Cutaneous T Cell Lymphoma Presenting as Papuloerythroderma of Ofuji / 대한피부과학회지

Papuloerythroderma of Ofuji (PEO) is an uncommon entity of unknown etiology, characterized by coalescing erythematous papules sparing skin folds. A number of cases have described the association of this disorder with malignant with pathology, mainly with cutaneous T cell lymphoma. Such reports give rise to the suggestion that PEO may be a precursor of lymphoma or a form of cutaneous T cell lymphoma. We report a case of PEO, which was diagnosed as cutaneous T-cell lymphoma only 2 months after the development of skin lesions, and rapidly progressed. This case suggests the presence of a variant of cutaneous T cell lymphoma with clinical feature of PEO, which is different from mycosis fungoides or S zary syndrome.

A Case of Papuloerythroderma of Ofuji which Responded to Treatment with Cyclosporine / 대한피부과학회지

Papuloerythroderma of Ofuji is an uncommon dermatological disorder of unknown etiology and is characterized by a pruritic eruption of widespread confluent papules in vast sheets over the skin, but spares the skin folds (the so-called 'deck-chair' effect). We present a case of a patient with papuloerythroderma of Ofuji of unknown cause. Treatment with oral and topical corticosteroids, antihistamines, and narrow-band UVB phototherapy proved to be ineffective in helping the condition but considerable clinical improvement was obtained with cyclosporine.

A Case of Papuloerythroderma of Ofuji / 대한피부과학회지

Papuloerythroderma of Ofuji is a rare, distinctive clinical entity characterized by a widespread pruritic eruption of coalescence of flat-topped erythematous papules producing an erythroderma with sparing of the skin folds (the 'deck-chair' sign). Other common features of papuloerythroderma are blood eosinophilia, lymphopenia, a raised serum IgE and a nonspecific or eczematous-like histopathologic feature. Its etiology has been reported as variable, and the condition is thus considered as a pattern of cutaneous expression induced by a range of pathological process for systemic disease. We experienced a 71-year-old male patient with a 4-month history of a generalized pruritic eruption which clinical features were compatible with papuloerythroderma of Ofuji. Treatment with systemic steroid resulted in marked improvement.