Contenido de sodio en antimicrobianos parenterales: Una fuente extra de sodio a considerarse en pacientes hospitalizados / Sodium content in parenteral antibiotics: An extra source of sodium to be considered in hospitalized patients

Los antimicrobianos parenterales son esenciales en el tratamiento de infecciones intrahospitalarias, sin embargo, es importante considerar la carga de sodio y volumen que pueden aportar, especialmente, en pacientes con restricción sódica. En el presente estudio se identificaron los antimicrobianos parenterales usados en uno de los hospitales más grandes del Perú. Se revisó la cantidad de sodio intrínseco y se calculó la cantidad de sodio total por día de tratamiento según el régimen frecuentemente usado en adultos. Como resultado, se encontró que 22% de las terapias antimicrobianas superaban el requerimiento de sodio diario, lo que podría ser perjudicial para pacientes con insuficiencia cardiaca, enfermedad renal crónica, con cirrosis hepática, entre otros.

Parenteral antibiotics are essential in the treatment of nosocomial infections; however, their sodium load and volume should be considered as an extra source, especially, in patients with sodium restriction. In this study, we identified the parental antibiotics used in one of the largest hospitals in Peru. We reviewed the amount of intrinsic sodium and we calculated the sodium load per day of treatment according to the commonly used regimen in adults. As a result, we found that 22% of the antibiotic treatment regimens exceed the daily sodium requirement, which could be harmful for patients with heart failure, chronic kidney disease, liver cirrhosis, among others.

Cost variation analysis of parenteral antibiotics in Indian pharmaceutical market

Background: The objective of the present study was to analyse price differences between parenteral antibiotics available in a tertiary care teaching hospital.Methods: The study was done in the Department of Pharmacology of S. D. M. College of Medical Sciences, Dharwad, Karnataka. Latest volume of current index of medical specialties or Indian Drug Review was used to analyze the prices of parenteral antibiotics.Results: Overall, prices of 17 single drug antibiotics available in 37 strengths marketed and 8 fixed-dose combinations available in 16 strength marketed were analyzed. It was observed that the maximum cost variation among the single ingredient parenteral antibiotic was with cefpirome 1000 mg. The price difference being Rs. 283 and the cost variation being 90.7%. The minimum price variation was seen with Ampicillin 100 mg of Rs. 4.3 and the cost variation being 40.2%. Additionally the highest price difference was also seen teicoplanin 400 mg i.e., Rs. 610 and its cost variation being 68.5%. Among the fixed-dose combination (FDC抯) the maximum price variation was observed in the combination of cefoperazone+sulbactum 1000+1000 of Rs. 340. Whereas the cost variation of the same was 212.5 %. The minimum price variation among the FDC抯 was of the combination of ceftriaxone 250 mg + tazobactum 31.25 mg Rs. 3.3 and its cost variation being 7.9 %.Conclusions: Pharmacoeconomics facets must be taken into deliberation by healthcare practitioners while prescribing antibiotics to the patients for infectious disease treatment. This will assist compliance, reduce antibiotic resistance and treatment failure.

Uso de antibióticos parenterales en el servicio de medicina interna de un hospital de tercer nivel de la ciudad de Bogotá / Parenteral antibiotics utilization in the internal medicine service of a third level hospital from Bogota city

Mediante un estudio observacional y de corte transversal, relacionado con el esquema terapéutico, se describió el consumo y las prácticas de prescripción de antibióticos parenterales en el servicio de medicina interna del Hospital Universitario La Samaritana de Bogotá. Se administraron 32,6 ddd/100 pacientes/día, siendo los grupos terapéuticos más prescritos: cefalosporinas, penicilinas y quinolonas. Los errores en el esquema terapéutico se presentaron en el régimen de dosificación, en la elección del medicamento y en la duración del tratamiento. Del presente estudio se extraen los primeros indicadores de consumo y prescripción para el servicio, estableciendo un punto de referencia para próximas evaluaciones.

A cross-sectional and observational study related with therapeutic plan, was described the utilization and prescription practices of parenteral antibiotics, in the internal medicine service of the Hospital Universitario La Samaritana E.S.E from Bogota city. Were administered 32.6 ddd/100 patients-day. The most prescribed therapeutic groups were: cephalosporins, penicillins and quinolones. The errors in the therapeutic plan were in: the dosification regimen, the drug selection and the therapy duration. From this study were extracted the first consumption and prescription indicators to the service, for establishing a reference point to next evaluations.