Cuidados de enfermagem às pessoas com doença de Parkinson na Atenção primária à Saúde: protocolo de scoping review / Nursing care for people with Parkinson's disease in Primary Health Care: a scoping review protocol

Resumo Objetivo: Identificar na literatura os principais temas investigados sobre cuidados de enfermagem à pessoa com doença de Parkinson na atenção primária à saúde. Metodologia: Trata-se de um protocolo de revisão de escopo, realizado de acordo com a metodologia do Joanna Briggs Institute e checklist do Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR), seguindo as seguintes etapas: protocolo; critérios de elegibilidade; fontes de informação; estratégia de pesquisa; seleção de fontes de evidência; extração dos dados; análise de dados e apresentação dos resultados. Tem como pergunta de revisão: Quais os cuidados de enfermagem à pessoa com doença de Parkinson em nível de atenção primária à saúde, descritas na literatura? Para identificar documentos relevantes, as seguintes bases de dados bibliográficas serão pesquisadas: Public Medline, Cumulative Index to Nursing & Allied Health Literature, Web of Science, SciVerse Scopus, Base de Dados de Enfermagem, Literatura Latino-Americano e do Caribe em Ciências da Saúde, e Scientific Electronic Library Online. O resultado do fluxo de seleção, desta etapa metodológica, será apresentado em forma de figura, conforme o Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Resultados: Os resultados deste estudo possibilitarão o conhecimento das principais áreas de cuidados e intervenções de enfermagem voltadas a pessoas com doença de Parkinson, na atenção primária à saúde. Conclusão: Este estudo constitui o primeiro passo em uma agenda de pesquisa que visa aprofundar a análise e sistematização dos cuidados de enfermagem às pessoas que vivem com doença de Parkinson.

Resumen Objetivo: Identificar en la literatura los principales temas investigados sobre el cuidado de enfermería para personas con enfermedad de Parkinson en atención primaria de salud. Método: Es un protocolo de revisión de alcance, llevado a cabo de acuerdo con la metodología del Instituto Joanna Briggs y la lista de verificación de los elementos de informes preferidos para revisiones sistemáticas y extensión de metaanálisis para revisiones de alcance(PRISMA-ScR), siguiendo los siguientes pasos: protocolo, criterio de elegibilidad, fuentes de información, estrategia de investigación, selección de fuentes de evidencia, extracción de datos, análisis de datos y presentación de resultados. Tiene como pregunta de revisión la siguiente: ¿cuáles son los cuidados de enfermería brindados a las personas con enfermedad de Parkinson en el nivel de atención primaria de salud, descritos en la literatura? Para identificar documentos relevantes, se buscó en las siguientes bases de datos bibliográficas: Medline pública, Índice acumulativo de literatura de enfermería y salud aliada, Web of Science, SciVerse Scopus, Base de datos de enfermería, Literatura latinoamericana y caribeña en ciencias de la salud y Scientific Electronic Library en línea. El resultado del flujo de selección, de este paso metodológico, se presentará en forma de figura, de acuerdo con los elementos de informes preferidos para revisiones sistemáticas y metaanálisis. Resultados: Los resultados de este estudio permitirán conocer las principales áreas de atención e intervenciones de enfermería dirigidas a personas con enfermedad de Parkinson, en la atención primaria de salud. Conclusión: Este estudio es el primer paso de una agenda de investigación que tiene como objetivo profundizar en el análisis y sistematización de la atención de enfermería a las personas que viven con la enfermedad de Parkinson.

Abstract Aim: To identify in the literature the main topics investigated about nursing care for people with Parkinson's disease in primary health care. Method: This is a scope review protocol carried out according to the Joanna Briggs Institute methodology and the Preferred Reporting Items for Systematic reviews checklist and the Meta-Analyzes extension for Scoping Reviews(PRISMA-ScR). This investigation will follow these steps: protocol, eligibility criteria, information sources, research strategy, selection of sources, data extraction, data analysis, and presentation of results. Its review question is "What are the nursing cares provided to people with Parkinson's disease in primary health care as described in the literature?". To identify the relevant documents, the following bibliographic databases will be used: Public Medline, Cumulative Index to Nursing & Allied Health Literature, Web of Science, SciVerse Scopus, Nursing Database, Latin American and Caribbean Literature in Health Sciences, and Scientific Electronic Library Online. The results of this selections flow will be presented using figures as outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes. Results: The results of this study will shed light on the main researched areas of care and nursing interventions aimed at people with Parkinson's disease in primary healthcare. Conclusion: This study is the first step in a research agenda that aims to deepen the analysis and systematization of nursing care for people living with Parkinson's disease.

Studieson the characteristics of cerebral blood flow changes in MRI perfusion imaging in patients with cognition disorders in Parkinson disease and their correlation with serum epidermal growth factor / 中国医师进修杂志

Objective:To explore the characteristics of cerebral blood flow changes in MRI perfusion imaging in patients with Parkinson disease (PD) cognition disorders and its correlation with serum epidermal growth factor (EGF) level.Methods:One hundred and twenty PD patients diagnosed and treated from September 2017 to September 2020 in Hangzhou Third People′s Hospital were selected. According to the presence of mild cognitive impairment (MCI), they were divided into PD-MCI group (60 cases) and PD without cognition impairment (PD-NCI) group (60 cases). Another 60 cases of healthy physical examination during the same period were selected as the normal control group. MRI perfusion imaging was used to evaluate the cerebral vascular perfusion in each group, and the EGF level of each group was determined by enzyme-linked immunosorbent assay and compared.Results:The CBF and CBV in the PD-MCI group and PD-NCI group were lower than those in the normal control group, while the MTT was longer than that in the normal control group:(14.78 ± 2.49), (18.21 ± 2.84) ml/(100 g·min) vs. (18.21 ± 2.84) ml/(100g·min); (1.42 ± 0.29), (1.83 ± 0.31) ml/100 g vs. (2.87 ± 0.54) ml/100 g; (10.53 ± 2.18), (7.85 ± 1.39) s vs. (4.29 ± 1.05) s, and the differences were statistically significant ( P<0.05). The CBF and CBV in the PD-MCI group were lower than those in the PD-NCI group, while MTT was longer than that in the PD-NCI group, and the differences were statistically significant ( P<0.05). The level of serum EGF in the PD-MCI group and PD-NCI group were lower than those in the normal control group: (146.25 ± 30.12), (208.17 ± 21.25) ng/L vs. (242.38 ± 25.46) ng/L; the level of serum EGF in the PD-MCI group was lower than that in the PD-NCI group, and the differences were statistically significant ( P<0.05). CBF, CBV and EGF were linearly positively correlated with Montreal Cognitive Assessment Scale (MoCA) scores ( r1 = 0.810, r2 = 0.732, r3 = 0.825, P<0.05), while MTT was linearly negatively correlated with MoCA scores ( r4 = -0.756, P<0.05). Conclusions:PD-MCI patients have abnormal cerebral blood flow, and serum EGF level decrease. In PD-MCI patients, CBF, CBV and EGF are linearly positively correlated with MoCA scores, while MTT is linearly negatively correlated with MoCA scores.