Recommendations from the Brazilian Society of Anesthesiology (SBA) for difficult airway management in pediatric care

Abstract Difficult airway management in pediatrics during anesthesia represents a major challenge, requiring a careful approach, advanced technical expertise, and accurate protocols. The task force of the Brazilian Society of Anesthesiology (SBA) presents a report containing updated recommendations for the management of difficult airways in children and neonates. These recommendations have been developed based on the consensus of a panel of experts, with the objective of offering strategies to overcome challenges during airway management in pediatric patients. Grounded in evidence published in international guidelines and expert opinions, the report highlights crucial steps for the appropriate management of difficult airways in pediatrics, encompassing assessment, preparation, positioning, pre-oxygenation, minimizing trauma, and, paramountly, the maintenance of arterial oxygenation. The report also delves into additional strategies involving the use of advanced tools, such as video laryngoscopy, flexible intubating bronchoscopy, and supraglottic devices. Emphasis is placed on the simplicity of implementing the outlined recommendations, with a focus on the significance of continuous education, training through realistic simulations, and familiarity with the latest available technologies. These practices are deemed essential to ensure procedural safety and contribute to the enhancement of anesthesia outcomes in pediatrics.

Anesthetic and surgical considerations for staged bilateral nephrectomies in a pediatric patient: A case report / Consideraciones anestésicas y quirúrgicas en nefrectomía bilateral en dos tiempos en un paciente pediátrico: Reporte de caso

Abstract We present a 9-year-old patient with end-stage renal disease, on peritoneal dialysis, who underwent a staged prone retroperitoneoscopic bilateral nephrectomy. Bilateral nephrectomy was indicated in preparation for renal transplant in the context of genetic predisposition malignancy when immunosuppressed. The two mirror-image surgeries enable the comparison of the anesthetic management and outcomes in a single patient. Features of interest to anesthesiologists include approach to a child with chronic kidney disease, different requirements for intraoperative antihypertensives; pain management strategies, including a comparison of erector spinae plane block with and without adjunct dexmedetomidine; anesthetic management of retroperitoneoscopic pediatric surgery and the first description of using a Foley bag attached to a peritoneal dialysis catheter to aid in diagnosis and repair of posterior peritoneal cavity entry.

Resumen Se presenta un paciente de 9 años de edad con enfermedad renal terminal, en diálisis peritoneal, quien se sometió a nefrectomía bilateral retroperitoneoscópica estadificada en posición prona. Se indicó la nefrectomía bilateral en preparación para trasplante renal en el contexto de predisposición genética hacia desarrollar una patología maligna al estar inmunosuprimido. Las dos cirugías en espejo permiten hacer una comparación del manejo anestésico y de los desenlaces en un mismo paciente. Las características de interés para los anestesiólogos incluyen el abordaje de un niño con enfermedad renal crónica, con requisitos diferentes de antihipertensivos intraoperatorios; estrategias para el manejo del dolor, incluyendo una comparación de bloqueo del plano del erector espinal con y sin dexmedetomidina adyuvante; manejo anestésico de cirugía pediátrica retroperitoneoscópica y la primera descripción del uso de una bolsa Foley conectada a un catéter de diálisis peritoneal para ayudar en el diagnóstico y la reparación de la entrada de la cavidad peritoneal posterior.

Anesthesia in a child with arthrogryposis multiplex congenita – how to proceed: A case report

Arthrogryposis multiplex congenita (AMC) consists of a heterogenous group of disorders characterized by non-progressive congenital joint contractures. They have tense skin, minimal subcutaneous tissue, and muscle mass. The anesthetic management of these children is complicated by associated congenital abnormalities, airway anomalies, congenital heart disease, pulmonary hypoplasia, and vertebral anomalies. We managed a case of AMC with bilateral contractures of both upper and lower limb and neck who presented for correction of bilateral equino varus.

Tecnologías y estrategias de ventilación mecánica en anestesia para pacientes pediátricos / Technologies and strategies for mechanical ventilation in pediatric patient's anesthesia

Safe mechanical ventilation in pediatric anesthesia includes the use of protective ventilatory strategies. In anesthesia, the evidence-based literature is scarce and derives from intensive care and adult patients. New technologies, monitoring and knowledge of applied pathophysiology allow these data to be extrapolated. The technological advance in ventilators of the new anesthesia machines has allowed its use in smaller patients with greater safety, deploying more ventilatory modes for use in the operating room. The programming of the ventilator must be done looking for physiological objectives according to the stage of the child's development, step of anesthesia and surgery, in a dynamic and individualized way. This narrative review aims to summarize the available evidence about intraoperative pediatric mechanical ventilation and provide practical clinical recommendations aimed at optimizing the performance of the anesthesia machine, applying safe ventilatory strategies in pediatric patients.

Una ventilación mecánica segura en anestesia pediátrica incluye el uso de estrategias ventilatorias protectoras. En anestesia la literatura basada en la evidencia al respecto es escasa, deriva del intensivo y del paciente adulto. Las nuevas tecnologías, moni- torización y el conocimiento de la fisiopatología aplicada, permiten extrapolar estos datos. El desarrollo del avance tecnológico de los ventiladores de las nuevas máquinas de anestesia, ha permitido su uso en pacientes cada vez más pequeños y con mayor seguridad, desplegando más modos ventilatorios para uso en pabellón. La programación del ventilador debe ser buscando objetivos fisiológicos según la etapa del desarrollo del niño, la etapa del proceso anestésico y la cirugía, de manera dinámica e individualizada. La presente revisión narrativa pretende resumir la evidencia disponible sobre ventilación mecánica pediátrica intraoperatoria y entregar recomendaciones clínicas prácticas orientadas a optimizar las prestaciones de la máquina de anestesia, aplicando estrategias ventilatorias seguras en el paciente pediátrico.

Anestesia segura para cada niño: Hablemos de SAFETOTS / Safe anesthesia for every child: Lest's talk about SAFETOTS

Children have the right to enjoy the highest attainable standard of health. This basic human right is anchored in the "United Nations Convention on the Rights of the Child (UNCRC)" and was adopted in 1989. Pediatric anesthesia is a high-risk specialty with anesthesia-related complications approximately 10 times more frequent when compared with adults resulting higher mor- bidity and mortality. Children are different from adults from an anatomical, physiological, pharmacological, psychological point and safe conduct of pediatric anesthesia requires profound knowledge, experience, manual skills and professional attitude of the practitioner. This also necessitates institutional support in a child appropriate clinical environment. Unfortunately, we are still far away from fulfilling this commitment in anaesthesia and continué to be hampered by the lack of human and physical resources, organization, and training. Safe Anesthesia for Every Tot (safetots.org) is an initiative of leading international pediatric anesthe- tists that advocates safe and quality anesthesia for all children. It is based on the rights of the children ('10R'), the provision of perioperative physiological homeostasis ('10N'), defines the '5W' (Who, Where, What, When and HoW), critical events '10C', provides a roadmap for education, teaching and training and identifies specific areas of critical importance for safe perioperative care. This review provides an overview of the perioperative safety in pediatric anesthesia and explores strategies to minimize risks.

Los niños tienen derecho a disfrutar del más alto estándar de salud posible. Este derecho humano básico está fundamentado en la "Convención de las Naciones Unidas sobre los Derechos del Niño (UNCRC)" y fue adoptado en 1989. La anestesia pediátrica es una especialidad de alto riesgo; con complicaciones relacionadas con la anestesia aproximadamente 10 veces más frecuentes cuando es comparado con los adultos llevando a mayor morbilidad y mortalidad. Los niños son diferentes de los adultos desde el punto de vista anatómico, fisiológico, farmacológico, psicológico y la conducción segura de la anestesia pediátrica requiere un conocimiento profundo, experiencia, habilidades manuales y actitud profesional del médico. Esto también requiere apoyo institucional en un entorno clínico apropiado para niños. Desafortunadamente, todavía estamos lejos de cumplir con este compromiso en anestesia y sigue siendo obstaculizado por la falta de recursos humanos, físicos, organizacionales y de educación y entrenamiento. Safe Anesthesia for Every Tot (safetots.org) es una iniciativa de anestesiólogos pediátricos internacionales que promueven una anestesia segura y de calidad para todos los niños. Se basa en los derechos de los niños ('10R'), el aseguramiento de la homeostasis fisiológica perioperatoria ('10N'), define las '5W' (Quién, Dónde, Qué, Cuándo y Cómo), eventos críticos '10C', proporciona una hoja de ruta para la educación, la enseñanza y la formación e identifica áreas específicas de importancia crítica para la atención perioperatoria segura. Esta revisión proporciona una descripción general de la seguridad perioperatoria en anestesia pediátrica y explora estrategias para minimizar los riesgos.

Actualización del paro cardiorrespiratorio perioperatorio pediátrico / Perioperative cardiac arrest

Perioperative cardiopulmonary arrest (CRP) in pediatric anesthesia is a rare but catastrophic event. Its incidence has decreased over time to advance in peri-anesthetic care for patients, as well as the availability of better equipment. It is estimated that in developed countries the incidence can reach 3-5/1,000 anesthesia when patients undergoing cardiac surgery are included. The risk factors remain similar in different studies, among them the most relevant risk factors are age less than 1 year old, ASA status III or more, urgent or emergency surgeries, type of surgery, anesthesia load and time of the day of occurrence. The respiratory and cardiovascular are most relevant immediate causes. The neurological prognosis and survival rate are superior to those of cardiopulmonary arrest in children in other settings. The key factor in the successful management of perioperative cardiopulmonary arrest in pediatric patients, is the adherence to the cardiopulmonary resuscitation protocols.

El paro cardiorrespiratorio (PCR) perioperatorio en anestesia pediátrica es un evento raro, pero catastrófico. Su incidencia ha ido disminuyendo con el tiempo gracias a los avances en los cuidados perianestesicos de los pacientes, así como a la disponibilidad de mejor equipamiento. Se estima que en países desarrollados la incidencia puede alcanzar a 3-5/1000 anestesias cuando se incluyen los pacientes sometidos a cirugía cardiaca. Los factores de riesgo se mantienen similares en los distintos estudios, entre ellos los más relevantes son la edad menor de un año, el ASA elevado (III o más), cirugía de urgencia o emergencia, el tipo de cirugía, la carga de anestesias y el horario de ocurrencia. Las causas inmediatas más importantes son las respiratorias y las cardiovasculares. El pronóstico neurológico y la tasa de sobrevida son mejores que los de un paro cardiaco en niños en otros escenarios. La adherencia a protocolos de resucitación cardiopulmonar son claves en el manejo exitoso de paro cardiorrespiratorio perioperatorio en pediatría.

Fluidoterapia perioperatoria en el paciente pediátrico / Perioperative fluids in pediatric patients

Fluid therapy is the most widely used medical treatment, with indications and risks that are important to know. Its indication in the pediatric perioperative period has continuously changed with the upward understanding of the physiology of newborns, infants and children, as well as in the knowledge of the composition of the different fluids available for use in this patient's population. This is evident in the various existing guidelines on this topic. It is important to consider the preoperative fasting of our patient, which must be decreased to the maximum. We must differentiate the two objectives of fluid therapy: maintenance and replacement fluid therapy. The latest recommendations on maintenance fluid therapy indicate preferring the use of balanced solutions, and if not having these, preferring lactate ringer serum by adding glucose for a concentration of 1-2.5%, especially in patients with a higher risk of hypoglycemia. On the other hand, in replacement fluid therapy, it should always be started with crystalloids preferring isotonic balanced solutions of electrolytes. The use of colloids is controversial given the scarce scientific evidence in pediatric patients. Finally, when indicating blood products, the risks associated with transfusion should always be considered, however, we should also consider the threshold of hematocrit and platelets to transfuse if necessary, and calculate the maximum volume of blood loss allowed to be transfused.

La fluidoterapia es el tratamiento médico más ampliamente utilizado, con indicaciones y riesgos que es importante conocer. Su indicación en el perioperatorio pediátrico ha cambiado continuamente a medida que se avanza en la comprensión de la fisiología de los recién nacidos, lactantes y niños, como también en el conocimiento de la composición de los diferentes fluidos disponibles para su uso en esta población de pacientes. Esto queda en evidencia en las diversas guías existentes respecto al tema. Es importante considerar el ayuno preoperatorio de nuestro paciente, que debe ser disminuido al máximo. Debemos diferenciar los dos objetivos de la fluidoterapia: fluidoterapia de mantención y de reposición. Las últimas recomendaciones sobre fluidoterapia de mantención indican preferir el uso de soluciones balanceadas, y de no disponer de éstas, preferir suero ringer lactato añadiendo glucosa para una concentración de 1%-2,5%, especialmente en pacientes con mayor riesgo de hipoglicemia. Por otro lado, en la fluidoterapia de reposición, se debe iniciar siempre con cristaloides prefiriendo soluciones balanceadas isotónicas de electrolitos. El uso de coloides es controversial dado la escasa evidencia científica en pacientes pediátricos. Por último, al indicar hemoderivados, siempre se deben considerar los riesgos asociados a transfusión, sin embargo, también debemos considerar el umbral de hematocrito y plaquetas para transfundir en caso necesario, y calcular el volumen de pérdida sanguínea máxima permitida para transfundir.

Pediatric airway: What is new in approaches and treatments? / Vía aérea pediátrica: ¿Hay novedades en su abordaje y tratamiento?

Abstract Perioperative morbidity and mortality are high among patients in the extremes of life undergoing anesthesia. Complications in children occur mainly as a result of airway management-related events such as difficult approach, laryngospasm, bronchospasm and severe hypoxemia, which may result in cardiac arrest, neurological deficit or death. Reports and new considerations that have changed clinical practice in pediatric airway management have emerged in recent years. This narrative literature review seeks to summarize and detail the findings on the primary cause of morbidity and mortality in pediatric anesthesia and to highlight those things that anesthetists need to be aware of, according to the scientific reports that have been changing practice in pediatric anesthesia. This review focuses on the identification of "new" and specific practices that have emerged over the past 10 years and have helped reduce complications associated with pediatric airway management. At least 9 practices grouped into 4 groups are described: assessment, approach techniques, devices, and algorithms. The same devices used in adults are essentially all available for the management of the pediatric airway, and anesthesia-related morbidity and mortality can be reduced through improved quality of care in pediatrics.

Resumen Los pacientes en extremos de la vida sometidos a anestesia tienen la más alta morbimortalidad perioperatoria. Los niños se complican principalmente por eventos derivados del manejo de la vía aérea pediátrica (VAP), como dificultad en su abordaje, laringoespasmo, broncoespasmo e hipoxemia severa, que pueden terminar en paro cardiaco, déficit neurológico o muerte. En los últimos años se han informado y retomado aspectos que cambian la práctica clínica sobre la VAP Esta revisión narrativa de la literatura busca concretar y resumir estos hallazgos sobre la primera causa de morbimortalidad en anestesia pediátrica y enfatizar en lo que los anestesiólogos deben conocer, con base en los informes científicos que vienen cambiando la práctica anestésica pediátrica. Esta revisión busca identificar las conductas "nuevas" y concretas que han surgido en los últimos 10 años, y que ayudan a disminuir las complicaciones derivadas del manejo de la VAP Se señalan y describen al menos nueve conductas agrupadas en 4 bloques: Evaluación, técnicas de abordaje, dispositivos y algoritmos. Actualmente se cuenta con prácticamente todos los dispositivos de adultos para el manejo de la VAP y con consideraciones específicas se puede mejorar la calidad de la atención y reducir la morbimortalidad anestésica en pediatría.

General anesthesia for Crisponi syndrome: case report / Anestesia geral para Síndrome de Crisponi: relato de caso

Abstract Crisponi syndrome is a rare and severe heritable disorder characterised by muscle contractions, trismus, apnea, feeding troubles, and unexplained high fever spikes with multiple organ failure. Here we report perioperative care for endoscopic gastrostomy of a 17 month-old female child with Crisponi syndrome. Temperature in the surgery room was strictly monitored and maintained at 19ºC. The patient was exposed to both inhaled and intravenous anesthetic agents. Surgical and perioperative periods were uneventful. Episodes of fever in Crisponi syndrome arise from CRLF1 mutation, which differs from the physiological pathway underlying malignant hyperthermia.

Resumo A Síndrome de Crisponi é uma condição clínica hereditária grave e rara caracterizada por contrações musculares, trismo, apneia, distúrbios na alimentação, picos de febre alta e inexplicável, e falência de múltiplos órgãos. Descrevemos o cuidado perioperatório de paciente pediátrica com 17 meses de idade, portadora da Síndrome de Crisponi, submetida a gastrostomia endoscópica. A temperatura da sala de cirurgia foi cuidadosamente monitorizada e mantida a 19ºC. A paciente foi submetida a agentes anestésicos inalatórios e venosos. O cuidado cirúrgico e perioperatório desenvolveram-se sem incidentes. As crises de febre na Síndrome de Crisponi originam-se de mutação no gene CRLF1, o que as diferenciam do mecanismo fisiopatológico da hipertermia maligna.

Different anesthesia management in preterm infants undergoing surgeries for retinopathy of prematurity: A retrospective study / 北京大学学报(医学版)

OBJECTIVE@#To evaluate the effect of different anesthesia management on clinical outcomes in former prematurely born infants undergoing surgeries for retinopathy of prematurity (ROP).@*METHODS@#In this retrospective study, electronic medical record database was searched for all former prematurely born infants (gestational age < 37 weeks and post conceptual age < 60 weeks) who received ROP surgery under inhalational general anesthesia between November 2016 and October 2018. The patients were divided into two groups based on anesthesia management: laryngeal mask airway (LMA) insertion without intravenous muscle relaxant injection and with pressure support ventilation (LMA group) or airway secured with endotracheal tube (ETT) with intravenous muscle relaxant injection and pressure controlled ventilation (ETT group). Primary outcomes included perioperative adverse events and complications. Extubation time and length of stay after surgery were also recorded.@*RESULTS@#Sixty eight preterm infants in the LMA group and 100 preterm infants in the ETT group were included. The incidence of adverse events during surgery (including airway management change and desaturation) was similar in LMA group and ETT group (4.4% vs. 1.0%, P =0.364). During the early recovery period after surgery, the incidence of difficult extubation (extubation time >30 min) was significantly lower in LMA group compared with ETT group (4.4% vs.15.0%, RR=0.262, 95%CI:0.073－0.942, P=0.029). The incidence of respiratory events was similar between the two groups (20.6% vs. 27.0%, P =0.342). However, the incidence of apnea was significantly lower in the LMA group than in the ETT group (5.9% vs.19.0%, RR=0.266, 95%CI: 0.086－0.822, P =0.015). No significant difference was observed between the LMA group and ETT group in incidences of cardiovascular events (0% vs. 1.0%, P =1.000) and unplanned admission to neonatal intensive care unit (5.9% vs. 7.0%, P=0.774). No airway spasm, re-intubation, aspiration or regurgitation was observed during early recovery. During late recovery after returning to ward, the incidence of adverse events was also similar between the two groups (0% vs. 2.0%, P =0.241). The median (IQR) extubation time was 6 (5, 10) min in LMA group and 10 (6, 19) min in ETT group (P < 0.001). The median length of stay after surgery was significantly shortened in LMA group compared with ETT group [20 (17, 22) hours vs. 22 (17, 68) hours, P =0.002].@*CONCLUSION@#Compared with endotracheal intubation with intravenous muscle relaxant injection, laryngeal mask airway insertion without muscle relaxant could achieve an early extubation, and reduce the incidence of apnea during early recovery period in former prematurely born infants undergoing ROP surgery.

Efectividad de la máscara laríngea Ambu® Aura40TM para anestesia general en cirugía ortopédica pediátrica / Effectiveness of Ambu® Aura40TM laryngeal mask for general anesthetic in pediatric orthopedic surgery

RESUMEN Introducción: las máscaras laríngeas son dispositivos supraglóticos utilizadas ampliamente en anestesia para el abordaje y mantenimiento de la vía respiratoria. Una de ellas, la Ambu® Aura 40TM, tiene un diseño que le permite ajustarse al entorno de la hipofaringe con su lumen dirigido a la apertura laríngea. Ha demostrado ser adecuada para procedimientos quirúrgicos donde no es necesaria la intubación endotraqueal. Objetivo: determinar la efectividad dicha máscara laríngea para anestesia general en cirugía ortopédica pediátrica. Materiales y métodos: se realizó un estudio descriptivo, prospectivo, transversal, en 135 pacientes intervenidos quirúrgicamente de forma electiva en el Hospital Pediátrico Eliseo Noel Caamaño, de Matanzas, en el periodo enero de 2015- junio 2017. Se tuvo en cuenta el número de intentos y el tiempo para insertar la máscara laríngea, la necesidad de reemplazarla por un tubo endotraqueal y las complicaciones relacionadas con su uso. Resultados: la ML Ambu® Aura 40TM fue efectiva en la mayoría de los pacientes ya que permitió realizar la cirugía sin necesidad de sustituirla por el tubo endotraqueal y la aparición de complicaciones relacionada con su uso fue baja. Conclusiones: la ML Ambu® Aura 40TM fue efectiva ya que en la mayoría de los pacientes fue insertada correctamente en el primer intento y un tiempo inferior a los 20 segundos. Solo una minoría necesitó que fuera reemplazada por el tubo endotraqueal, y la aparición de complicaciones relacionada con su uso fue baja (AU).

ABSTRACT Introduction: laryngeal mask are supra glottal devices widely used in anesthetics for approaching and maintaining the airway. One of them, the Ambu® Aura 40TM, has a design allowing to adjust to the surroundings of hypo-pharynx with its lumen directed to the pharyngeal opening. It has demonstrated to be adequate for surgical procedures when there is no need of endotracheal intubation. Objective: to determine the effectiveness of that laryngeal mask for general anesthetic in pediatric orthopedic surgery. Materials and methods: a cross-sectional, prospective, descriptive study was carried out in 135 patients who underwent elective surgical intervention in the Pediatric Hospital ?Eliseo Noel Caamaño?, of Matanzas, in the period January 2015- June 2017. The number of attempts and the time needed to insert laryngeal mask, the necessity of changing it for an endotracheal tube, and complications related to its usage were taking into account. Results: Ambu® Aura 40TM laryngeal mask was effective in most patients, due to it allowed to perform the surgery without need of changing it for an endotracheal tube, and the low appearance of complications related to its use. Conclusions: Ambu® Aura 40TM laryngeal mask was effective because it was inserted correctly at the first attempt, in a time less than 20 seconds. Only a minority needed to replace it by endotracheal tube, and the appearance of complications related to its use were low (AU).

Comparison of Caudal Anesthesia and Ilioinguinal Block for Pediatric Inguinal Surgeries and Postoperative Analgesia

Background and Objective: Infants and children undergo a variety of groin procedures that can cause a significant degree ofdiscomfort postoperatively. We aim to compare the caudal block and ilioinguinal/iliohypogastric block using the combination ofropivacaine and dexmedetomidine with regard to efficacy, quality, and duration of post-operative analgesia.Methods: This study included two groups and 60 patients of the age group of 3–12 years. After induction of anesthesia, GroupAreceived caudal block using 1 ml/kg 0.2% ropivacaine + dexmedetomidine 0.3 μg/kg up to maximum of 20 ml. Group B receivednerve locator guided ilioinguinal/iliohypogastric block using 0.75 ml/kg 0.2% ropivacaine + dexmedetomidine 0.3 μg/kg up tomaximum of 20 ml. Postoperatively, patients were monitored for up to 24 h for primary objective of measurement of pain score,duration of analgesia, and number of rescue analgesia required. Statistical analysis performed using independent t-test andChi-square test. P < 0.05 was considered statistically significant.Results: The highest pain score in Group A was 5.93 ± 1.53 and in Group B was 4.93 ± 1.64 (P < 0.05). The average durationof analgesia in Group A and Group B was 372 min and 680 min, respectively (P < 0.05). The mean number of rescue analgesiagiven in Group A was 1.47 and in Group B was 0.96 (P < 0.05).Conclusion: Both caudal block and ilioinguinal block are effective measure of post-operative pain relief in pediatric inguinalsurgeries, but ilioinguinal block is better in terms of efficacy, duration of analgesia, lesser dose of local anesthetic required, andlesser need of rescue analgesia required.

Anesthesia and perioperative challenges for surgical separation of thoraco-omphalopagus twins: case report / Anestesia e desafios perioperátorios para cirurgia de separação de gêmeos toraco-onfalópagos: relato de caso

Abstract Background and objectives: Conjoined twins are monozygotic twins physically joined at some part of the body. This is a rare phenomenon, estimated between 1:50,000 and 1:200,000 births. The objective of this report is to present the anesthetic management and the perioperative challenges for a separation surgery. Case report: Thoraco-omphalopagus twins were diagnosed by ultrasound and were followed by the fetal medicine team of the service. After 11 h of cesarean surgery, the pediatric surgical team chose to separate the twins. They were monitored with cardioscopy, oximetry, capnography, nasopharyngeal thermometer, urinary output, and non-invasive blood pressure. We chose inhaled induction with oxygen and 4% Sevoflurane. T1 patient was intubated with a 3.5 uncuffed endotracheal tube, and, after three unsuccessful intubation attempts of patient T2, a number 1 laryngeal mask was used. After securing the twins' airway, the induction was supplemented with fentanyl, propofol, and rocuronium. Mechanical ventilation in controlled pressure mode (6 mL.kg−1) and lumbar epidural (L1-L2) with 0.2% ropivacaine (2.5 mg.kg−1) were used. The pediatric surgical team initiated the separation of the twins via sternotomy, ligation of hepatic vessels. After 2 hours of procedure, the separation was completed, continuing the surgical treatment of T1 and the support of T2 until his death. Conclusions: Conjoined twin separation surgery is a challenge, which requires planning and coordination of a multidisciplinary team during all stages.

Resumo Justificativa e objetivos: Gêmeos conjugados são gêmeos monozigóticos conectados por alguma parte do corpo. Esse é um fenômeno raro, estimado entre 1:50.000 a 1:200.000 nascimentos. O objetivo deste relato é apresentar o manejo anestésico e os desafios perioperatórios para cirurgia de separação. Relato de caso: Gêmeos toraco-onfalópagos foram diagnosticados por ultrassonografia e acompanhados pela equipe de medicina fetal do serviço. Após 11 horas da cesárea, a equipe cirúrgica pediátrica optou pela separação dos gêmeos. Foram monitorados com cardioscopia, oximetria, capnografia, termômetro nasofaríngeo, débito urinário e pressão arterial não invasiva. Optou-se por indução inalatória com oxigênio e sevoflurano a 4%. O G1 foi intubado com tubo orotraqueal 3,5 sem cuff e após três tentativas de intubação do G2 sem sucesso usou-se máscara laríngea número 1. Após obtenção da via aérea nos gêmeos, complementou-se indução com fentanil, propofol e rocurônio. Ventilação mecânica no modo pressão controlada 6 ml.kg-1 e peridural lombar L1-L2 com ropivacaína 0,2% (2,5 mg.kg-1). A equipe cirúrgica pediátrica iniciou a separação dos gêmeos através de esternotomia, ligadura de vasos hepáticos. Após duas horas de procedimento, a separação foi concluída, prosseguiram-se o tratamento cirúrgico de G1 e os cuidados de G2 até o óbito. Conclusões: A cirurgia de separação de gêmeos conjugados é um desafio, requer planejamento e coordenação de uma equipe multidisciplinar durante todos os estágios.

Caracterización de los episodios de agitación durante la emergencia de la anestesia general en pediatría / Characterization of agitation episodes during the emergence from general anesthesia in Pediatrics

RESUMEN Introducción: la agitación durante la emergencia de la anestesia general es una complicación frecuente en pediatría que puede causar daños físicos, retrasar el alta y aumentar los costos. Objetivo: caracterizar los episodios anestesia general en el paciente pediátrico. Materiales y métodos: se realizó un estudio descriptivo, prospectivo, longitudinal de 246 pacientes que presentaron anestesia general en el Hospital "Eliseo Noel Caamaño" entre septiembre de 2015 y diciembre de 2018. Se estudiaron las variables: edad, género, ASA, tiempo quirúrgico y tiempo anestésico, tipo de cirugía, método de anestesia, agentes usados para la inducción y el mantenimiento, severidad de los episodios y necesidad de tratamiento. Resultados: la mayoría de los pacientes que presentaron anestesia general tenían entre 2 y 6 años (63,4%), eran masculinos (67,9%), ASA I (78,1%) y fueron operados de excéresis de lesiones de partes blandas (27,6%). El tiempo quirúrgico fue de 31,2 ± 10,4 minutos y el anestésico 43,5±8,8 minutos. El método anestésico más indicado fue la anestesia balanceada (84,2%), como inductor el propofol (86,2%) y para el mantenimiento isoflurano (34,1%) y sevoflurano (26,4%). Predominaron los episodios severos (51,2%) y el 56,9% necesitó intervención farmacológica. Conclusiones: esta anestesia fue más frecuente en los menores de seis años, masculinos, sanos, a los cuales se les realizaron procederes cortos, con anestesia balanceada, se usó propofol para la inducción e isoflurano y sevoflurano para el mantenimiento de la anestesia. Prevalecieron los episodios severos y la mayoría requirió tratamiento farmacológico.

ABSTRACT Introduction: agitation during the emergence from general anesthesia is a frequent complication in Pediatrics that can cause physical damages, delay discharge and increase costs. Objective: to characterize the episodes of general anesthesia in the pediatric patient. Materials and methods: a descriptive, prospective, longitudinal study was carried out with 246 patients who presented general anesthesia in the Hospital "Eliseo Noel Caamaño" from September 2015 to December 2018. The studied variables were age, gender, ASA, surgical time, anesthetic time, kind of surgery, anesthetic method, agents used for the induction and maintenance, episodes severity and treatment necessity. Results: most of patients treated with general anesthesia were aged 2-6 years (63.4 %), male (67.9 %), ASA I (78.1 %), and underwent the removal of soft parts lesions (27.6 %). The average surgical time was 31,2 ± 10,4 minutes and the anesthetics one was 43,5±8,8 minutes. The most used anesthetics method was balanced anesthesia (84.2 %), the most used inductor was propofol (86.2 %) and for the maintenance isoflurane (34,1%) and sevoflurane (26,4%). Severe episodes (51,2%) predominated, and 56.9 % needed pharmacologic intervention. Conclusions: this kind of anesthesia is more frequently used in children aged less than 6 years, male, healthy, who underwent short procedures with balanced anesthesia and the use of propofol for the induction and isoflurane and sevoflurane for maintaining it. Severe episodes predominated, and most of them required pharmacologic treatment.

Application effect of preoperative intranasal dexmedetomidine in pediatric anesthesia / 中国基层医药

Objective To observe the clinical effects of preoperative intranasal dexmedetomidine in pediatric anesthesia.Methods From April 2014 to April 2017,40 pediatric patients who accepted elective circumcision,ASA Ⅰ,aged 2 to 10 years in Wenjiang Branch of Sichan Provincial People's Hospital were divided into two groups,with 20 cases in each group.The test group received intranasal dexmedetomidine 1 μg/kg,and the control group received intranasal equal volume of saline 30 min before surgery.HR,SpO2,BP were monitored and recorded before intranasal (T0),5min after intranasal (T1),10min after intranasal (T2),20min after intranasal (T3),30min after intranasal (T4).The sedation score was assessed after 30 min of administration.The restless score was observed after waking.Results ANOVA analysis showed that there were significant differences in SBP (F =14.54,P ＜ 0.05) and DBP (F =22.69,P ＜ 0.05) between the two groups,and the SBP (F =13.77,P ＜ 0.05),DBP (F =10.48,P ＜ 0.05),HR(F =5.13,P ＜ 0.05) had interaction effects.Compared with those of the control group,the heart rate and the diastolic pressure of the test group were decreased at T2 ～ T4 (all P ＜ 0.05).The sedation score of the test group was superior than that of the control group(t =-9.131,P ＜0.05),and the postoperative agitation score was lower than that of the control group (t =3.387,P ＜ 0.05).Conclusion Intranasal dexmedetomidine can provide satisfactory sedative effects without affecting the vital signs of children and significantly reducing the postoperative agitation.

Anesthesia management of selective ophthalmic intra-arterial chemotherapy for retinoblastoma / 上海交通大学学报（医学版）

Objective: To investigate the safety of treatment with ophthalmic artery cannulation for intra-arterial chemotherapy (IAC) in children with retinoblastoma (RB) during general anesthesia. Methods: A total of 60 children with RB who underwent ocular artery interventional chemotherapy under general anesthesia in Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine from September 2015 to August 2018 were collected. Induction of anesthesia was performed with rapid induction of endotracheal intubation with midazolam, fentanyl, propofol and rocuronium. Sevoflurane and oxygen were administered for maintenance of general anesthesia, with intermittent injection of rocuronium and fentanyl. Intraoperative continuous monitoring of hemodynamic parameters, respiratory parameters (EtCO2, oxygen saturation and inspiratory peak pressure) and sevoflurane minimum alveolar concentration (MAC) was performed, and intraoperative pulmonary compliance, hypoxemia, hypotension and other cardiopulmonary adverse events were observed and recorded. Results: Over a 3-year period, 185 treatment sessions were performed in 60 patients. Thirty-two cardiopulmonary adverse events were observed in 20 patients, and the incidence rate was 17.2%, mainly including severe decrease in lung compliance, hypoxemia and arterial hypotension. All severe decreases in lung compliance occurred within 1 or 2 minutes after catheter insertion in the ophthalmic artery. After active treatment with propofol, phenylephrine and epinephrine, no death and permanent sequelae occured. Conclusion: An appreciable incidence of trigeminocardiac reflex to intra-ophthalmic artery infusion of chemotherapy in patients with RB is found. Both interventionalists and anesthesiologists should be aware of this potential event and be prepared to provide immediate resuscitative measures.

Bloqueo del erector de la espina en cirugía torácica pediátrica / Erector spinae plane block in thoracic pediatric surgery

Thoracotomy is associated with intense pain. In the pediatric population, the pain affects the ventilatory mechanics, which is also strongly influenced by the characteristics of the respiratory tract and chest according to the age. Therefore, regional techniques are strongly recommended. In 2016, ESP is described for the first time, which generates extensive sensory block in the chest wall, without approaching the pleura and the neuroaxial space from the technical point of view. At present, there is increasing experience in different surgical settings, but it is still scarce in pediatric patients. We present the successful application of the technique in 2 pediatric cases of thoracic surgery and various outcomes are described.

La toracotomía está asociada con intenso dolor. En la población pediátrica, el dolor afecta la mecánica ventilatoria, que además se ve fuertemente influida por las características propias de las vías respiratorias y del tórax según la edad. Por lo anterior, las técnicas regionales están fuertemente recomendadas. En 2016 se describe por primera vez el ESP, que genera bloqueo sensitivo extenso en la pared torácica, sin aproximarse desde el punto de vista técnico a la pleura y al espacio neuroaxial. En la actualidad, existe experiencia en aumento en diversos settings quirúrgicos, pero es aún escasa en pacientes pediátricos. Presentamos la aplicación exitosa de la técnica en 2 casos pediátricos de cirugía torácica, así como la descripción de diferentes resultados posoperatorios.

Application of nalmefene hydrochloride in pediatric laryngeal mask anesthesia / 上海交通大学学报（医学版）

Objective: To evaluate clinical anesthetic effects of nalmefene hydrochloride in pediatric laryngeal mask anesthesia. Methods: Sixty pediatric patients who underwent short-time eye surgeries were randomly divided into nalmefene hydrochloride group (Group N) and the control group (Group C), 30 patients each group. At the end of the surgeries, patients of Group N and Group C were respectively given nalmefene hydrochloride at 0.25 μg/kg and 0.9% sodium chloride at the same volume intravenously. The situation of the patients' respiration recovery was recorded 1, 2, 3, 4 and 5 minutes after administration, including the time on which the patients' respiration was recovered and their laryngeal masks were removed. The sedation scores (Ramsay scores) and the incidence of adverse postoperative responses were recorded after the removal of the laryngeal mask. Results: The 5-minute respiration recovery rate was high in Group N, where the 3-minute respiration recovery rate was 83.0%, while only 16.7% in Group C. Besides, respiration recovery time [(3.17±0.78) min] and time for removing laryngeal mask [(4.10±0.95) min] in Group N were shorter than those of Group C (both P0.05). After removing laryngeal mask, the incidence of adverse responses was lower in Group N than that in Group C (P<0.05). Conclusion: Nalmefene hydrochloride is effective in shortening respiration recovery time and laryngeal masks removing time, but makes no difference in patients' sedative effects, with lower incidence of adverse postoperative respiratory responses.

Application of nalmefene hydrochloride in pediatric laryngeal mask anesthesia / 上海交通大学学报（医学版）

Objective·To evaluate clinical anesthetic effects of nalmefene hydrochloride in pediatric laryngeal mask anesthesia.Methods· Sixty pediatric patients who underwent short-time eye surgeries were randomly divided into nalmefene hydrochloride group (Group N) and the control group (Group C),30 patients each group.At the end of the surgeries,patients of Group N and Group C were respectively given nalmefene hydrochloride at 0.25 μg/kg and 0.9％ sodium chloride at the same volume intravenously.The situation of the patients' respiration recovery was recorded 1,2,3,4 and 5 minutes after administration,including the time on which the patients' respiration was recovered and their laryngeal masks were removed.The sedation scores (Ramsay scores) and the incidence of adverse postoperative responses were recorded after the removal of the laryngeal mask.Results· The 5-minute respiration recovery rate was high in Group N,where the 3-minute respiration recovery rate was 83.0％,while only 16.7％ in Group C.Besides,respiration recovery time [(3.17±0.78) min] and time for removing laryngeal mask [(4.10±0.95) min] in Group N were shorter than those of Group C (both P＜0.05).No significant difference was found in postoperative sedation scores between these two groups (P＞0.05).After removing laryngeal mask,the incidence of adverse responses was lower in Group N than that in Group C (P＜0.05).Conclusion· Nalmefene hydrochloride is effective in shortening respiration recovery time and laryngeal masks removing time,but makes no difference in patients' sedative effects,with lower incidence of adverse postoperative respiratory responses.

Effect of ketamine and sufentanyl on respiratory depression induced by propofol in pediatric patients / 新乡医学院学报

Objective To compare the effect of ketamine and sufentanyl on respiratory depression induced by propofol in pediatric patients.Methods Sixty children with taplipes equines in the Department of Pediatric Orthopedics,the Third Affiliated Hospital of Zhengzhou University from February 2014 to August 2015 were selected and divided into ketamine group,sufentanil group and control group,with 20 patients in each group.The patients in ketamine group were given ketamine 1.50 mg· kg-1 by intravenous injection and maintained with ketamine 0.75 mg · kg-1 · h-1 by pump infusion;the patients in sufentanil group were given sufentanil 0.2 μg · kg-1 by intravenous injection and maintained with sufentanil 0.1 μg · kg-1 · h-1 by pump infusion;the patients in control group were given the same volume of saline.The initial plasma concentration of propofol in ketamine group,sufentanil group and control group was 1.1 mg · L-1,and the ratio between the two successive concentration gradients was 1.1.It was defined as positive when patients developed respiration depression.The bispectral index (BIS) and the observer's assessment of alertness/sedation (OAA/S) score of patients in the three groups were recorded at the time point of intravenous infusion ketamine or sufentanil (T1),3 min after propofol target controlled infusion (TCI) (T2),5 min after propofol TCI (T3) and after the target effect-site and plasma concentrations were balanced(T4).The target effect-site concentration was recorded when the BIS dropped to 65 or OAA/S score was 3.The median effective concentration(EC50) and its 95％ confidence interval (CI) of propofol inducing respiratory depression were calculated.Results There was no statistic difference in BIS and OAA/S scores of patients at the time point of T1 among the three group(P ＞ 0.05);the BIS and OAA/S scores of patients in ketamine group and sufentanil group were significantly lower than those in the control group at the time point of T2,T3 and T4 (P ＜ 0.05);the BIS and OAA/S scores of patients in ketamine group were significantly lower than those in the sufentanil group at the time point of T2,T3,T4 (P ＜ 0.05).The EC50 and its 95 ％ CI of respiratory depression induced by propofol in ketamine group,sufentanil group and the control group were 1.75 (1.56-2.34),1.86 (1.47-2.23),2.82 (2.56-3.02) mg · L-1 respectively.The EC50 of patients in ketamine group and sufentanil group was significantly lower than that in control group (P ＜ 0.05),but there was no statistic difference in EC50 of patients between the ketamine group and sufentanil group (P ＞ 0.05).Conclusion Both ketamine and sufentanil can increase the EC50 of respiratory depression induced by propofol in pediatric patients,but the effects of both drugs are the same.Ketamine and sufentanil can reduce the BIS and OAA/S scores of patients,enhance the sedation efficacy of propofol,and the effect of ketamine is better than sufentanil.