Chemical Constituents from Leaves of Pileostegia viburnoides Hook.f.et Thoms

Phytochemical investigation on the leaves of Pileostegia viburnoides Hook.f.et Thoms led to the isolation of twenty-five compounds, and their structures were identified as n-dotriacontane (1), taraxeryl acetate (2), friedelin (3), epifriedelinol (4), canophyllal (5), stigmast-4-en-3-one (6), stigmasterol (7), (24R)-5A-stigmastane-3,6-dione (8), ursolic acid (9), pomolic acid (10), umbelliferone (11), 4-epifriedelin (12), n-octatriacontanol (13), β-amyrin (14), α-amyrin (15), taraxerol (16), nonadecanol (17), friedelane (18), arachic acid (19), protocatechuic acid (20), n-pentatriacontanol (21), hexadecanoic acid (22), vincosamide (23), daucosterol (24), and skimming (25), respectively. To our best knowledge, compounds 1, 2, 12, 13, 17 - 19 and 21-23 were new within Saxifragaceae family. Compounds 15, 16, and 20 were produced from this genus for the first time. Compounds 4, 14 and 25 were first obtained from species P. viburnoides and compounds 3, 5 - 11, and 24 were achieved from the leaves of P. viburnoides for the first time. Furthermore, the anti-neuroinflammatory activity of these isolates was evaluated.

Chemical constituents from cane of Pileostegia viburnoides / 中草药

Objective: To study the chemical constituents from the cane of Pileostegia viburnoides. Methods: The compounds were isolated and purified by silica gel and Sephadex LH-20 column chromatography. Their structures were identified on the basis of their physicochemical properties and spectroscopic data. Results: Thirteen compounds were isolated from the cane of P. viburnoides and their structures were identified as friedelin (1), 3-oxo-nofriedelin-28-al (2), stigmast-4-en-3-one (3), stigmasterol (4), (24R)-5A- stigmastane-3, 6-dione (5), tetracosyl amine (6), ursolic acid (7), pomolic acid (8), oleanolic acid (9), umbelliferone (10), 4-hydroxymellein (11), cleomiscosin A (12), and daucosterol (13), respectively. Conclusion: Compound 6 is obtained as a natural product for the first time; Compounds 2-5, 7-9, 11, and 12 are obtained from this genus for the first time and all the compounds are obtained from P. viburnoides for the first time.