Outcomes and rational clinical use of extended or continuous versus intermittent infusion of piperacil-lin/tazobactam / 中国药学杂志

OBJECTIVE: To introduce the research progress of dosage regimen of piperacillin/tazobactam and its rational offer reference for clinical use. METHODS: The domestic and oversea pertinent articles were searched, analyzed and summarized, and the difference between prolonged infusion or continuous infusion and traditional infusionin pharmacodynamics and clinical trials were compared. RESULTS: The optimized dosage regimen could achieve higher pharmacodynamics goals, with clinical efficacy and bacterial clearance not inferior to the traditional dosage regimen. CONCLUSION: The prolonged or continuous infusion strategy should be recommended for piperacillin/tazobactam in the clinic.