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1.
Rev. argent. endocrinol. metab ; 57(4): 11-20, dic. 2020. graf
Artículo en Español | LILACS-Express | LILACS | ID: biblio-1155671

RESUMEN

Dada la importancia obstétrica y metabólica de la Diabetes Gestacional, hemos querido estudiar las correlaciones de los biomarcadores de primer trimestre con el peso fetal en las 20 semanas y con el de la madre en las 28 semanas para embarazadas con y sin diabetes gestacional, en una investigación desarrollada en atención primaria. Se trata de un estudio de casos y controles. Las variables cuantitativas analizadas han sido: PAPPA (Pregnancy Associated Plasma Protein A) (mU/ml), Betahidroxicoriónica (ngrs/ml), TSH (pUI/ml) y T4 libre (ngrs/dl) a las 12 semanas, peso fetal a las 20 semanas y peso materno en kilogramos a las 28 semanas. Como variable complementaria descriptiva hemos utilizado la edad en años de la gestante. Se han muestreado seis centros de salud del Distrito Sanitario de Atención Primaria de Sevilla (España). Utilizamos la regresión lineal simple por el método de los mínimos cuadrados y la técnica de suavización denominada LOESS (Locally Weighted Scatterplot Smoothing). Destacamos sobre todas las demás, las correlaciones inversas y las líneas de mínimos cuadrados de las variables PAPPA y TSH en las 12 semanas de gestación, y las correlaciones entre peso fetal a las 20 semanas con Betahidroxicoriónica y con PAPP-A. La más importante es la primera por el cambio y la magnitud de la R2 de Pearson (+0,10) en gestantes con diabetes gestacional. Hemos encontrado un cambio ostensible en la correlación de la PAPP-A con la TSH en las gestantes con Diabetes Gestacional. El intervalo de confianza superior del coeficiente de correlación llega a alcanzar +0,3. Una posible explicación fisiopatológica para esta correlación encontrada en nuestro trabajo podría ser la acción de la TSH sobre los factores de crecimiento similares a insulina en células osteoblásticas humanas.


Given the obstetric and metabolic importance of Gestational Diabetes, we wanted to study the correlations of the first trimester biomarkers with the weight of the fetus at 20 weeks and with that of the mother at 28 weeks of gestation for pregnant women with and without gestational diabetes in a research carried out in primary care. This is an observational study of cases and controls. The quantitative variables analyzed were: PAPPA (Pregnancy Associated Plasma Protein A) (mU / ml), Betahydroxychorionic (ngrs / ml), TSH (pUI / ml) and free T4 (ngrs / dl) at 12 weeks, fetal weight at 20 weeks and maternal weight in kilograms at 28 weeks. As a descriptive balancing variable, we have used the age of the pregnant woman in years. Six health centers of the Primary Healthcare District of Seville (Spain) have been sampled. We applied simple linear regression using the least squares method and the smoothing technique called LOESS (Locally Weighted Scatterplot Smoothing). A finding was highlighted above all the others, the inverse correlations and the least squares lines of the PAPP-A and TSH variables at 12 weeks of gestation, and the correlations between fetal weight at 20 weeks with Betahydroxychorionic and with PAPPA. The most important is the first because of the change and the magnitude of Pearson's R2 (+0.10) in pregnant women with gestational diabetes. We have found a noticeable change in the correlation of PAPPA with TSH in pregnant women with Gestational Diabetes. The upper confidence interval of the Pearson correlation coefficient reaches +0.3. A possible pathophysiological explanation for this correlation found in our work could be the action of TSH on insulin-like growth factors in human osteoblastic cells

2.
Chinese Journal of Rheumatology ; (12): 464-466,封3, 2018.
Artículo en Chino | WPRIM | ID: wpr-707877

RESUMEN

Objective To investigate the effect and mechanism of placental protein 14 on the proliferation and differentiation of B cells.Methods The lymphocyte of human peripheral blood was separated by gradient centrifugation.Flow cytometry was used to detect the proportion of CD4+CXCR5+follicular helper T cells (Tfh cells),CD4+CXCRS+Foxp3+ follicular regulatory T cells (Tfr cells),CD3-CD19+B cells and CD3-CD38+ plasma cells.ELISA method was used to detect the concentration of IL-21,IL-10 and TGF-beta in the supernatant,and the co-culture of cells was performed by Transwell chamber;t test was used for comparison between groups.Results The proportion of Tfh cells and Tfr cells in the control group was (2.52±0.16)% and (1.26±0.24)%,respectively,and that of the placental protein 14 groups were (0.84±0.09)% and (4.64±0.68)%,respectively.There was a significant difference between the two groups (t=9.150,P=0.000 8 and t=4.669,P=0.009 5).Pplacental protein 14 could further inhibit the secretion of IL-21 (t=5.086,P=0.007 1),and promote the increase of IL-10 and TGF-β concentration (t=3.599,P=0.022 8 and t=6.651,P=0.002 7).The percentage of B cells and plasma cells in the placental protein 14 group were (4.87±0.20)% and (5.41±0.54)%,which were significantly different from those in the Tfh cell group (t=4.997,P=0.007 5;t=5.110,P=0.006 9).Conclusion Placental protein 14 can inhibit the proliferation of B cells and differentiate into plasma cells by inhibiting the differentiation of Tfh cells and increasing the proportion of Tfr cells.

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