RESUMEN
Objective:To analyze the related factors of neurotoxicity induced by oxaliplatin chemotherapy in patients with colorectal cancer and its prevention and treatment strategies.Methods:A total of 300 patients with colorectal cancer treated with oxaliplatin in Zhejiang Cancer Hospital from January 2018 to December 2020 were randomly selected for baseline collection using the convenience sampling method. The occurrence of oxaliplatin-induced peripheral neurotoxicity (OIPN) was statistically analyzed. The factors that affect the occurrence of OIPN were analyzed using univariate analysis.Results:There was a significant difference in OIPN score between patients of different genders, between patients who had different education levels, between patients who had different occupations, and between patients who lived in different long-term residence places ( t = 7.29, 3.39, 2.53, 18.11, all P < 0.05). There was no significant difference in OIPN score between patients adhering to different religion's beliefs, between patients married and not, between patients who lived with and without members, between patients who paid medical costs and not, and between patients who had a previous history of smoking and not ( t = 3.25, 0.37, 0.69, 2.39, 0.15, all P > 0.05). There was a significant difference in OIPN score between patients with different tumor-node-metastasis stages, between patients who received medication via different administration routes, and between patients who received different times of oxaliplatin administration ( t = 8.40, 3.34, 3.49, all P < 0.05). Conclusion:Medical staff should pay attention to the occurrence of OIPN in patients with colorectal cancer treated with oxaliplatin, focus on the patient's factors related to the disease, and take correct and effective coping strategies promptly to reduce the adverse reactions, improve the quality of life, and ensure the therapeutic effect.
RESUMEN
Platinum drugs are one of the key therapeutic drugs for many malignant tumors, but traditional platinum drugs have poor tumor targeting effect and obvious side effects, so it is necessary to improve the targeting of platinum drugs for increasing their antitumor activity. Sugars and their derivatives are indispensable substances for the transmission of information between cells. Tumor cells can specifically recognize, and effectively absorb drug molecules containing specific sugar through Warburg effect. The selectivity of traditional platinum drugs to tumor cells can be effectively improved by functional glycosylation. In addition, with reasonable glycosylation, there is significant improvement in the targeting effect and water solubility of platinum drugs, with low collateral effects. Therefore, the design of glycosyl platinum compounds is one of the hotspots in the field of anticancer platinum drugs. Based on the above background, the research progress in glycosylated platinum compounds in the field of antitumor treatment is reviewed.