RESUMEN
Objective To observe the clinical efficacy of Wenjing Shexue Recipe ( WSR) in treating polycystic ovarian syndrome ( PCOS) with liver-kidney deficiency, and to explore the possible therapeutic mechanism. Methods Seventy-four PCOS patients were randomized into observation group ( N=38) and control group ( N=36). The observation group was given oral use of WSR and the control group was treated with Ethinylestradiol and Cyproterone Acetate Tablets orally. Both groups received treatment for 6 months, and were followed up for 3 moths after drug withdrawal. After treatment, the therapeulic effect was evaluated , and the changes of body mass index ( BMI) , hairiness. acne, and sexual hormone levels were monitored before and after treatment. Results ( 1) The total effective rate of the observation gorup was 92.11% and that of the control group was 75.00%, the difference being significant ( P0.05) . The results of follow-up showed that BMI, the scores of hairiness and acne, and serum levels of T and LH were still lower in the observation group than those before treatment (P0.05 compared with those before treatment) and were higher than those of the observation group (P<0.05). Conclusion WSR exerts better effect for the treatment of PCOS with liver-kidney deficiency than Ethinylestradiol and Cyproterone Acetate Tablets, and the possible mechanism is probably related with the regulation of endocrine disturbance by decreasing serum T and LH levels.
RESUMEN
Objective To investigate the clinical efficacy of kidney-tonifying and blood-activating therapy on puberty polycystic ovarian syndrome(PCOS).Methods Thirty-one PCOS patients were randomly allocated into 2 groups:16 patients(TCM group)received kidney-tonifying and blood-activating Fuke No.5 Prescription combined with herbal medicine based on the menstrual cycle,and 15 patients(WM group)received oral administration of western medicine of diane-35.Changes of clinical symptoms and signs,B-ultrasonic results and serum hormones levels of follicle-stimulating hormone(FSH),luteinizing hormone(LH),prolactin(PRL),testosterone(T)and estrogen(E2)were examined before treatment,after treatment for 3 menstrual cycles and on the 3rd cycle after suspension.Results The menstuation and ovulation,serum sexual hormones(except FSH and E2)levels,and B-ultrasonic indexes(except the volume of uterus)were obviously improved in the two groups after treatment for 3 menstrual cycles(P0.05 compared with those before treatment),but remained at the levels after treatment for 3 menstrual cycles(P