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Objective To establish the optimum preparation process for Yinxingye Dropping Pills. Methods The preparation conditions, such as different kinds of primary substance, cooling agent, the proportion between the extracts and primary substance, etc, were studied with L9 (34) orthogonal design. Results At the following conditions could the best was 30 d/min, dropping distance was 8cm, and cooling temperature was 10℃. Conclusion This preparation process was suitable for both laboratory test and industrial production for Yinxingye Dropping Pills.
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OBJECTIVE:To optimize the forming technology for Zuojin dropping pill.METHODS:The base material and cooling agent were optimized by orthogonal experiment with the type of base material,the ratio of drug to base material,the temperature of physic liquor,the type of the cooling agent as factors taking the mixing state,forming condition and dissolution time as indexes; the dripping condition was optimized with the temperature of the cooling agent,the caliber of the dripping mouth,the dripping distance and dripping speed as factors taking the variation coefficient of the pill weight difference as index. RESULTS:The optimal forming technology was as follows:with polyglycol 4000 as base and paraffin oil as cooling agent; the cooling temperature was 12 ℃;the caliber of the dripping mouth was 3.5/4.9 mm;the dripping distance was 10 cm and the dripping speed was 25 drop?min-1.CONCLUSION:The forming technology is stable,reproducible and the preparation was well-shaped,and the forming technology serves as a reference for the production of Zuojin dropping pill.
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OBJECTIVE:To study the optimum formation technics of Xuesaitong drop pill.METHODS:Parallel tests were conducted on the dosage of different base materials and the main drug with the forming percentage and the rate of qualified weight as the index of evaluation,the orthogonal test was conducted on the4factors,including the temperature of drops and the liquor condensate,the drug height in the drug storage tank and the dropping distance.RESULTS:The ratio of base materials and the main drug was2.5∶1.The optimum forming technics could be seen as follows,the height of the drug storage tank was3cm,the temperature of drops was90℃,the dropping distance was5cm and the temperature of the liquor condensate was12.5℃.CONCLUSION:There was a high rate of end product of dropping pill prepared with this optimum process,which was in conformity with the standard stated in the Chinese Pharmacopoeia.
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A stent for bloodvessel anastomosis, with a slippery, soft out layer and a rapidly soluble inner layer, is developed in this paper. The out layer is made up of the gelatin with a high purity and a low molecular weight, and the inner one of polyglycol with a molecular weight of 20000. The structure changes of the stent surface are studied with anastomosis environment simulated. The result proves that the stent can be applied to bloodvessel anastomosis
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OBJECTIVE: To establish an optimized preparation process for Yegan Drop Pills. METHODS: The orthogonal test was applied to the selection of basic substance ( polyglycol) , temperature of cooling agent ( usoline) , and ratio in quantity of the extract to the basic substance. RESULTS: The optimal preparation process is under the condition of using polyglycol 4000, and cooling temperature at 10～ 15℃ . CONCLUSION: The Yegan Drop Pills prepared by using the technique are good in shape, stable in quality and easy to replicate. The technique can provide reference for the manufacture of Yegan Drop Pills.