RESUMEN
Background: Type 2 Diabetes mellitus is a metabolic syndrome that leads to hyperglycemia and complications in many organ systems. There are many ways to control hyperglycemia including diet, exercise, drugs, and insulin. Aim of the study: The purpose of this study was to determine the effects of diaphragmatic breathing exercises on blood sugar levels and to identify the effects of regular diaphragmatic breathing exercise on HbA1c. Subjects and Methods: The study design used was a randomized controlled trial. Random sampling technique was used. Data was collected from working female nurses of Services Hospital Lahore and Jinnah Hospital Lahore who had type-2 diabetes mellitus. By using Ballot method 64 subjects were selected and equally divided into 2 groups randomly (32 subjects were in an interventional group and 32 in the control group). Data were analyzed using SPSS version 20. Mean difference was measured by using independent sample t-test and paired t-test to see the pre and post effects of the same group. Results were summarized as mean and standard deviation. Results: The study results indicated that there was a significant reduction in fasting blood sugar level (p=0.009), post prandial blood sugar level (p=0.002) and post interventional blood sugar level (p=0.000) in the 9th week of the activity (breathing exercise). Pre and post the interventional mean difference in fasting blood sugar level was highly significant in the 12th week of intervention (p=0.000). No significant difference was found in the results of HbA1c (p=0.963). Conclusion: Diaphragmatic breathing exercise has favorable effects in controlling blood sugar levels among diabetes type-2 patients if it is combined with other exercises or therapies. Only breathing component cannot maintain the normal blood sugar level.
RESUMEN
Background: Diabetes mellitus is a major public health problem with many complications. The Global Burden of Diabetes Study has projected that there will be a 122% increase in the number of people with diabetes mellitus worldwide in 2025 compared to 1995. Despite the availability of new agents for the treatment of type 2 diabetes mellitus oral sulfonylureas remain a cornerstone of therapy. Glibenclamide and glimepiride are widely used sulfonylurea antidiabetic drugs. Methods: A randomized, open, parallel group study was conducted by the Department of Pharmacology in association with Department of Medicine at Maharishi Markandeshwar Institute of Medical Sciences & Research (MMIMSR), Mullana, Ambala. Total 50 patients were divided into two groups I & II. In Group I (n=25) glibenclamide (5-15 mg/day) & in Group II (n=25) glimepiride (1-6mg/day) was administered for a period of 24 weeks and data analyzed by Student’s “t”- test. Results: There was a significant improvement in the post prandial blood sugar score (p<0.05) in both the study groups (I&II) after 24 weeks but post prandial blood level did not differ significantly (p>0.05) between the two groups. Conclusions: Both the drugs glibenclamide and glimepiride were effectively reduced post prandial blood sugar in both the groups. But these sulfonylurea drugs lowered post prandial blood sugar to a similar degree without significant difference between the two groups.