Optimization on Formulation of Controlled-onset Extended-release Tablets of Nicorandil by Central Composite Design-response Surface Method / 医药导报

Objective To optimize the formulation of controlled-onset extended-release tablets of nicorandilby central composite design-response surface method. Methods The tablets containing nicorandil were prepared bydry-compression coating technique.The influence factors included the amount of HPMC, the amount of EC, and the ratio of lactose/MCC in coating film. The evaluation parameter was Q4 h and Q5 h . The possibly optimal formulation was predicted by response surface method. Results The OD was simulated using second-order polynomial equation and the r2was 0.970 1.Optimal prescription was as follows:HPMC 89.96 mg, EC 46.21 mg, Lactose/MCC 1.87.Bias between the observed and predicted values of the OD was within 0.43%. Conclusion The controlled-onset extended-release tablets of nicorandil can release drug quickly in vitro at the predetermined time.Central composite design-response surface method can be used to optimize the formulation and the model developed in this study was proved highly predictable.

An Exploration on the Prescription Composition Rules of the Compound Anti-influenza Preparations Made from Chinese and Western Medicines / 中国药房

The prescription composition rules and special features of compound anti-influenza preparationS made from Chinese and western medicines are explored in this paper. The problems in the prescription composition rules are also discussed.