Experimental Study on Effect of Radix Bupleuri Preparations on Proteinuria Induced by 5-1-6 Monoclonal Antibody / 中医杂志

A one - dose 5 - 1 - 6 monoclonal antibody injected intravenously can induce atransient massive proteinuria in rat. Comparison between Radix Bupleuritreating group and PBS control group 1, 3, 5, 8 days after injection showed significant difference. Under immuno -flourescence exam, the granular precipitation along the glomerular capillaries in experimental group decreased distinctively, yet the effect of Chailing Decoction on proteinuria can not be proved by oral infusion, suggesting that Radix Bupleuri may change the permeability of glomerular capillary in rat through certain mechanism.