Analysis of influencing factors of detecting radioactive iodine uptake by using thyroid function instrument / 中国医学装备

The radioactive iodine uptake(RAIU) has great value in determining the 131I treatment dosage of patients suffered from hyperthyroidism and judging thyroid function. Many factors which could interfere the results of RAIU were as follows: instrumental factors, thyroid radioactivity counts measurement, counts of a calibrated standard in a neck phantom and counts of room background, iodinated drugs and food, anti-thyroid medication, among other causes, have shown to induce varying degrees of errors in RAIU measurements. Irregular measurements which may interfere with radioactive iodine uptake are commonly seen in clinical practice, yet its actual influence has not been reported. Optimization, regularization and quality control of the radioiodine uptake measurement are essentials for clinical routine practice to guarantee appropriate values for clinical hyperthyroidism diagnosis and treatment. All the above factors affecting the measurement of thyroid function instrument for radioactive iodine uptake are analyzed and then put forward the corresponding solutions.

Therapy dose calculation in Graves disease using 4-hour I-131 uptake measurements: A retrospective study

Twenty-four-hour radioactive iodine uptake (RAIU) is commonly used to compute for therapy dose in Graves disease (GD). The purpose of this study is to determine the feasibility of using 4-hour RAIU in calculating the dose by correlating 4-hour with 24-hour RAIU and comparing the actual therapy dose using 24-hour RAIU with the computed dose using 4-hour RAIU. A total of 83 GD patients (71% female, 29% male;18-50 years old), who underwent RAI therapy at USTH Section of Nuclear Medicine, were included. There was a strong and positive correlation between 4-hour and 24-hour RAIU values (r=0.736). Paired t-test did not show a statistical difference between the actual given therapy dose based on 24-hour RAIU and the computed therapy dose using 4-hour RAIU (p 0.078). This study showed that therapy dose calculation using 4-hour RAIU can be used in Graves disease patients with no rapid turnover.

Study on the correlation of serum insulin-like growth factor-1 and radioactive iodine uptake rate in patients with nodular goiter / 中国医师进修杂志

Objective To study the correlation of the serum insulin-like growth factor-1(IGF-1) level and the radioactive iodine uptake rate in patients with nodular goiter,to explore a simple and saftymethods of identifying different kinds of thyroid nodule.Methods Sixty diagnosed cases was selected intohot nodule group(30 cases)and cool nodule group(30 cases),and 30 healthy people were selected into thehealthy control group.Measured the IGF-1,FT3,FT4,TSH level of each group by radioimmunoassay,and measured the radioactive iodine uptake rate by radionuclear technique.Results To compare with healthy control group,the levels of serum IGF-1,FT3,FT4 and the radioactive iodine uptake rate of hot nodule group were increased obviously,but the serum TSH was decreased significantly,and the level of IGF-1 had positive correhtion with the radioactive iodine uptake rate(r=0.835)in the same group.Meanwhile,the 1 evel of IGF-1 had negative correlation with the level of TSH(r=-0.326).In cool nodule group,the levels of serum IGF-1,FT3,FT4,TSH had no significant difference oompared with healthy control group(P>0.05).Conclusion The level of IGF-1 and radioactive iodine uptake rate in patients with nodular goiter has certain correlation.

Correlation of Thyroid Hormone Levels with Radioactive Iodine (1-131) Thyroid Uptakes

Radioactive iodine uptakes (RAIU) by thyroid gland is often performed to evaluate its functional status. How accurately it correlates with the Tri-iodothyronine (T3 ), Tetra-iodothyronine(T4) and thyroid stimulating hormone(TSH) radioimmunoassay (RIA) levels was studied in a total of 134 patients. It was observed that there was a significant positive correlation between 2 and 24 hours thyroid RAIU values with T3 & T, RIA values.