RESUMEN
Introduction: In newborns with hemolytic disease of fetusand newborn, exchange transfusion is one of the treatments.The main objective of this study was to review and establishthe practice of exchange transfusion with reconstituted bloodin neonates and to observe fall of bilirubin and also rise inhemoglobin and its comparison with related studies.Material and methods: Total 31 neonates with hemolyticdisease of fetus and newborn were included in thisstudy and exchange transfusion was carried out to treathyperbilirubinemia. Exchange transfusion with O Rh negativecells suspended in AB plasma were done for neonates havingRh hemolytic disease of fetus and newborn and O Rh positivecells suspended in AB plasma were used for exchangetransfusion to ABO hemolytic disease of fetus and newborn.The pre and post exchange transfusion blood samples weretested for serum bilirubin and hemoglobin.Result: Out of the 31 cases, 20 were of Rhesus (Rh) hemolyticdisease of fetus and newborn, while ABO and other bloodgroups constituted 08 and 03 hemolytic disease of fetus andnewborn cases respectively. The average post-exchange fallin serum indirect bilirubin was (53.47%) and average rise inhemoglobin level was 3.06 gm/dl in all 31 cases.Conclusion: The reconstituted blood is immunologically muchsafer and better than whole blood for purpose of exchangetransfusion in hemolytic disease of fetus and newborn becauseof its superiority in minimizing transfusion reactions and inachieving all the therapeutic effects of exchange transfusionin better way
RESUMEN
Objective To determine the efifcacy of exchange transfusion (ECT) with whole blood and reconstituted blood in neonatal hyperbilirubinaemia. Methods The clinical data of hyperbilirubinaemic neonates who had undergone ECT was reviewed. The neonates were categorized into three groups based on their ECT, whole blood (n=17), 1:1 ball-oplasm ratio reconstituted blood (n=18) and 2:1 ball-oplasm ratio reconstituted blood (n=20). Results There was no signiifcant difference in the demographic characteristics and causes of jaundice among the three groups. ABO blood incompatibility was the most com-mon cause of hyperbilirubinaemia in all groups. ECT with reconstituted or whole blood had no signiifcant effect on biochemi-cal indices of serum in patients. The levels of hemoglobin and hematocrit of 2:1 ball-oplasm ratio group were higher than those of other groups (P<0.05). The rates of hypocalcaemia and thrombocytopenia were similar in three groups after ECT. Conclu-sion ECT with 2:1 ball-oplasm ratio reconstituted blood can reduce the occurrence of anemia, and is more effective to treat neonatal hyperbilirubinaemia.