RESUMEN
Klotho gene is an anti-aging gene that is highly expressed in the kidney. Its encoding product Klotho protein can inhibit inflammation, oxidative stress injury, and apoptosis in renal tissue. It is regarded as a renal protective protein and expected to be a new target for the treatment of renal diseases. This article reviewed the biological characteristics of Klotho and the protective effect of Klotho on renal graft function.
RESUMEN
Most renal artery aneurysms are asymptomatic and the indication of surgery for renal artery aneurysm is controversial. We encountered 3 cases of renal artery aneurysms that were found incidentally during imaging studies. We used urological approach to undergo renal or adrenal surgery and we injected renal protection solution into the kidney after clamping the renal artery, later we underwent renal artery aneurysmectomy. In all cases, we got good operative field, and they went an uneventful postoperative course without deterioration of renal function. In surgical treatment of renal artery aneurysm, this approach method, reconstructive procedure, and renal protection are satisfied enough.
RESUMEN
OBJECTIVE To observe the renal protective effect of cultivated and wild Cordyceps sinensis on the the model mice of kidney-Yang deficiency, and to compare the differences of pharmacological effects between cultivated and wild Cordyceps sinensis. METHODS The model mice of kidney-Yang deficiency was induced by hydrocortisone in male mice which were randomly divided into seven groups: high dose group of cultivated Cordyceps sinensis, low dose of cultivated Cordyceps sinensis, high dose group of wild Cordyceps sinensis, low dose group of wild Cordyceps sinensis, control group, model group and positive drug group. The seven groups'index of physical status, swimming duration, gonad organ and immune organ, renal and testicular histology were observed. RESULTS Both cultivated and wild Cordyceps sinensis increased the body weight, prolonged the swimming time, improved sexual organ and immune organ index, ameliorated the pathological changes in renal and testicular histology, and enhanced the antioxidant ability of the model mice of kidney-Yang deficiency. There was no obvious difference in renal protective effect between cultivated and wild Cordyceps sinensis. CONCLUSION Both cultivated and wild Cordyceps sinensis can improve the kidney-Yang deficiency in male mice induced by hydrocortisone. Cultivated Cordyceps sinensis can be used as the alternative choice of wild Cordyceps sinensis in clinic.
RESUMEN
The purpose of this study was to evaluate the beneficial effects of organic and conventional grapevine (Vitis labrusca L.) leaf extracts in reducing hydrogen peroxide-induced stress in the liver, heart and kidney of Wistar rats by measuring lipids and proteins damages (carbonyl assay), as well as the activity of the antioxidant enzymes superoxide dismutase and catalase. The preincubation with 5 mg/mL of organic and conventional grapevine (Vitis labrusca L.) leaf extracts prevented both lipids and proteins oxidative damages in all tissues analyzed. The organic leaf extract was able to restore superoxide dismutase (kidney and liver) and catalase (heart) activities, which were modified by the treatment with H2O2. The conventional extract was able to restore only the catalase activity in liver and heart tissues. The beneficial effects of the V labrusca leaf extract shown in this study could probably be important for formulating dietary supplements, as well as for developing new ingredients with improved antioxidant properties from other plant sources.
O objetivo deste estudo foi avaliar os efeitos benéficos de extratos de folhas de videira (Vitis labrusca L.) orgânicas e convencionais em reduzir o dano gerado pelo peróxido de hidrogênio no fígado, coração e rim de ratos Wistar, pela medida de danos a lipídios e a proteínas (Ensaio Carbonyl), como também a modulação sob a atividade das enzimas antioxi-dantes superoxido dismutase e catalase. A pré-incubação com 5 mg/mL de extratos de folhas de videira (Vitis labrusca L.) orgânicas e convencionais previnem ambos danos oxidativos a lipídios e proteínas em todos os tecidos analisados. O extrato de folha orgânica foi capaz de restabelecer a atividade das enzimas superóxido dismutase (rim e fígado) e catalase (coração), as quais foram modificadas pelo tratamento com peróxido de hidrogênio. O extrato convencional foi capaz de restabelecer apenas a enzima catalase no fígado e no coração. Os efeitos do extrato da folha V. labrusca mostrados neste estudo, provavelmente, poderiam ser importantes para a formulação de suplementos dietéticos, bem como para o desenvolvimento de novos ingredientes com propriedades antioxidantes provenientes de outras plantas.