Growing teratoma syndrome: A case report / Philippine Journal of Obstetrics and Gynecology

@#Growing teratoma syndrome is a rare phenomenon. Presented is a case of a 36 year old, G2P2 (2002) who consulted for abdominal enlargement and subsequently underwent exploratory laparotomy, peritoneal fluid cytology, left salpingooophorectomy, right oophorocystectomy, infracolic omentectomy and random peritoneal biopsy. Histopathology revealed immature teratoma of the ovary, FIGO grade III, stage IIIC. She received adjuvant chemotherapy using Bleomycin, Etoposide, Cisplatin. After the second cycle of chemotherapy, new lesions were appreciated in the right ovary and at the cul de sac for which she underwent exploratory laparotomy, peritoneal fluid cytology, total hysterectomy with right salpingooophorectomy, tumor debulking, infragastric omentectomy, random peritoneal biopsy. Histopathologic study showed mature teratoma. No further treatment was given. Presently, patient has no evidence of disease for 5 months.

Síndrome de teratoma creciente: reporte de caso y revisión de la literatura / Growing teratoma syndrome: a case report and review of the literature

El síndrome de teratoma creciente (STC) es una condición poco común que se presenta en pacientes con tumores de células germinales no seminomatosos (TCGNS) de tipo teratoma inmaduro. Se caracteriza por la aparición de masas metastásicas que pueden alcanzar grandes volúmenes durante o después de la administración de la quimioterapia, asociado a la negativización de los marcadores tumorales. Histopatológicamente estas masas corresponden a un teratoma maduro. A continuación se presenta el caso de una paciente de 24 años, con diagnóstico de síndrome de teratoma creciente, incluyendo su evaluación, manejo quirúrgico y seguimiento a corto plazo.

The growing teratoma syndrome is a rare condition that occurs in patients with non-seminomatous germ cell immature teratoma. It is characterised by the appearance of metastatic masses that can reach large volumes during or after administration of chemotherapy, associated with the negative result for tumour markers. Histopathologically these masses correspond to a mature teratoma which is explained by a retroconversion phenomenon. The case is presented of a 24 year-old patient, diagnosed with growing teratoma syndrome, including her evaluation, surgical management, and short-term follow-up.